Gene: CASC8 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7014346
rs7014346
POU5F1B ; CASC8 ; PCAT1
0.010 GeneticVariation BEFREE Two signals were seen in regions already reported for prostate cancer risk. rs7014346 at 8q24.21 was marginally associated with aggressive prostate cancer in the BPC3 trial (p=1.6×10(-6)), whereas after meta-analysis by PRACTICAL the summary OR was 1.21 (95% CI 1.16-1.27; p=3.22×10(-18)). rs9900242 at 17q24.3 was also marginally associated with aggressive disease in the meta-analysis (OR 0.90, 95% CI 0.86-0.94; p=2.5×10(-6)). 25277271

2015
dbSNP: rs10505474
rs10505474
POU5F1B ; CASC8 ; PCAT1
0.010 GeneticVariation BEFREE rs10505474 and rs7837328 at 8q24 cumulatively confer risk of prostate cancer in Northern Han Chinese. 24815458

2014
dbSNP: rs378854
rs378854
CASC8 ; PCAT1 ; CASC21
0.010 GeneticVariation BEFREE This approach identified rs378854, which is in complete linkage disequilibrium (LD) with rs620861, as a novel functional prostate cancer-specific genetic variant. 21814516

2011
dbSNP: rs6470517
rs6470517
CASC8
0.010 GeneticVariation BEFREE Additionally, one of the significantly associated SNPs, rs6470517, with PC susceptibility showed a significant over-representation of the G allele in cases with aggressive tumor. 19562729

2009
dbSNP: rs7841264
rs7841264
CASC8
0.010 GeneticVariation BEFREE However, the association between prostate cancer risk and the CC genotype of rs7841264, which marked the recombination hotspot at 8q24, was confined to patients with the highest Gleason score (odds ratio, 2.15; 95% confidence interval, 1.27-3.64; P=0.004). 18765558

2008
dbSNP: rs7837328
rs7837328
POU5F1B ; CASC8 ; PCAT1
0.020 GeneticVariation BEFREE To study the association between the polymorphisms Arg462Gln and Asp541Glu from the RNASEL gene (1q25), and the polymorphisms rs620861, rs1447295, rs6983267, rs7837328 from the chromosome 8q24 with the risk of presenting prostate cancer (PCa) and its clinical characteristics in a Hispanic (Chilean) population. 24224612

2014
dbSNP: rs7837328
rs7837328
POU5F1B ; CASC8 ; PCAT1
0.020 GeneticVariation BEFREE rs10505474 and rs7837328 at 8q24 cumulatively confer risk of prostate cancer in Northern Han Chinese. 24815458

2014
dbSNP: rs13281615
rs13281615
POU5F1B ; CASC8 ; PCAT1 ; CASC21
0.020 GeneticVariation BEFREE Further studies are required to confirm whether the adjacent breast cancer-associated variant rs13281615 may be inversely associated with prostate cancer risk. 18625567

2009
dbSNP: rs13281615
rs13281615
POU5F1B ; CASC8 ; PCAT1 ; CASC21
0.020 GeneticVariation BEFREE We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls. 18349290

2008
dbSNP: rs620861
rs620861
POU5F1B ; CASC8 ; PCAT1 ; CASC21
0.030 GeneticVariation BEFREE We did not find strong evidence that associations between GWAS-identified SNPs and prostate cancer are modified by circulating concentrations of 25(OH)D. The intriguing interactions between rs620861 and rs16902094, 25(OH)D concentration, and fatal prostate cancer warrant replication. 28399564

2017
dbSNP: rs7000448
rs7000448
CASC8
0.030 GeneticVariation BEFREE The results of the meta-analyses indicate that rs6983267, rs1447295, rs6983561, rs7837688, rs16901979, and DG8S737 are significantly associated with a higher risk for PCa for at least one race, whereas the variants rs13254738 and rs7000448 are not. 22382457

2012
dbSNP: rs620861
rs620861
POU5F1B ; CASC8 ; PCAT1 ; CASC21
0.030 GeneticVariation BEFREE This approach identified rs378854, which is in complete linkage disequilibrium (LD) with rs620861, as a novel functional prostate cancer-specific genetic variant. 21814516

2011
dbSNP: rs7000448
rs7000448
CASC8
0.030 GeneticVariation BEFREE Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent. 20717903

2011
dbSNP: rs620861
rs620861
POU5F1B ; CASC8 ; PCAT1 ; CASC21
0.030 GeneticVariation BEFREE We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). 19767755

2009
dbSNP: rs7000448
rs7000448
CASC8
0.030 GeneticVariation BEFREE We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls. 18349290

2008
dbSNP: rs4506170
rs4506170
CASC8 ; PCAT1 ; CASC21
C 0.700 GeneticVariation GWASCAT Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. 27262462

2016
dbSNP: rs16902104
rs16902104
POU5F1B ; CASC8 ; PCAT1 ; CASC21
T 0.700 GeneticVariation GWASCAT A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. 26034056

2015
dbSNP: rs10505477
rs10505477
POU5F1B ; CASC8 ; PCAT1
A 0.700 GeneticVariation GWASCAT Genome-wide association scan for variants associated with early-onset prostate cancer. 24740154

2014
dbSNP: rs445114
rs445114
CASC8 ; PCAT1 ; CASC21
T 0.700 GeneticVariation GWASCAT Genome-wide association study identifies new prostate cancer susceptibility loci. 21743057

2011
dbSNP: rs445114
rs445114
CASC8 ; PCAT1 ; CASC21
T 0.700 GeneticVariation GWASCAT Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. 19767754

2009
dbSNP: rs16902094
rs16902094
CASC8 ; PCAT1 ; CASC21
0.720 GeneticVariation BEFREE A statistically significant interaction was observed for each of 2 SNPs in the 8q24 region (rs620861 and rs16902094), 25(OH)D concentration, and fatal prostate cancer on both multiplicative and additive scales (P ≤ 0.001). 28399564

2017
dbSNP: rs16902094
rs16902094
CASC8 ; PCAT1 ; CASC21
0.720 GeneticVariation BEFREE These included correlations between an intergenic CpG site at Chr8:128393157 and the prostate cancer SNP rs16902094 (ρ = -0.54; P = 9.7 × 10(-7); q = 0.002), a PRNCR1 CpG site at Chr8:128167809 and the prostate cancer SNP rs1456315 (ρ = 0.52; P = 1.4 × 10(-6); q = 0.002), and two POU5F1B CpG sites and several prostate/colorectal cancer SNPs (for Chr8:128498051 and rs6983267, ρ = 0.46; P = 2.0 × 10(-5); q = 0.01). 25315430

2014
dbSNP: rs16902094
rs16902094
CASC8 ; PCAT1 ; CASC21
G 0.720 GeneticVariation GWASCAT Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. 19767754

2009
dbSNP: rs1447295
rs1447295
CASC8
A 0.800 GeneticVariation GWASCAT 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. 31562322

2019
dbSNP: rs6983267
rs6983267
POU5F1B ; CASC8 ; PCAT1 ; CCAT2
G 0.800 GeneticVariation GWASCAT 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. 31562322

2019