| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | GeneticVariation | BEFREE | Viable cell growth, MDI, and polymorphism frequency in MTRR (A66G and C524T) and MTHFR (A1298C and A1793G) did not differ among the study groups; however, MDI tended to be higher in BRCA carriers with breast cancer than those without and was significantly increased in MTHFR 677T allele carriers relative to wild-type carriers (P=0.017). | 18842997 | 2008 |
||||
|
0.100 | GeneticVariation | BEFREE | To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer. | 16777985 | 2006 |
||||
|
0.100 | GeneticVariation | BEFREE | We found that the MTHFR SNPs, C677T and A1298C, were associated with breast cancer survival. | 17069650 | 2006 |
||||
|
0.100 | GeneticVariation | BEFREE | A meta-analysis of 18 case-control studies investigating the association between the C677T and the A1298C polymorphisms of the MTHFR gene and breast cancer (BC) was carried out. | 16630166 | 2006 |
||||
|
0.100 | GeneticVariation | BEFREE | We investigated independent and joint effects of B vitamin intake as well as two polymorphisms of a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C] on breast cancer risk. | 15735051 | 2005 |
||||
|
0.100 | GeneticVariation | BEFREE | The MTHFR C677T and A1298C polymorphisms are likely to play an important role in the susceptibility to br</span>east cancer. | 15004488 | 2004 |
||||
|
0.100 | GeneticVariation | BEFREE | No modifying effect of A1298C genotypes on the association of folate intake with breast cancer risk was observed. | 14973091 | 2004 |