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rs11133360
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It was found that both rare homozygotes in the ANLN:rs12535394 and KDR:rs11133360 SNP pair are prognostic of favorable breast cancer survival and underpin the prominent roles of the immune response in cancer state control.
|
31578580 |
2019 |
|
rs11133373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In analysis of the main effects of each single nucleotide polymorphisms(SNPs), variants in CLOCK rs11133373 was associated with breast cancer risk even after false discovery rate (FDR) correction (Odd Ratios (OR) = 1.38 (95% Confident Interval (CI) 1.14-1.69) in CG and CC compared to GG genotype.
|
31358835 |
2019 |
|
rs11212617
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>C</i> Allele of <i>ATM</i> rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin.
|
30984619 |
2019 |
|
rs11292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs1042713 in the ADRB2 gene and rs11292 in the 3'-UTR of the <i>HIF1AN</i> gene were associated with breast cancer susceptibility (<i>P</i><0.05).
|
30972198 |
2019 |
|
rs1143623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant G/C genotype of rs1143623 was associated with a significantly increased risk for BC (OR = 2.34, p < 0.05).
|
31297985 |
2019 |
|
rs11702450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the impact of two polymorphisms at the GANP locus (rs2839178 and rs11702450) on the susceptibility and prognosis of breast cancer.
|
30810967 |
2019 |
|
rs1175088679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified a likely damaging germline rs35352891 in the MUTYH gene (c.1118C>T, p.Ala373Val) in one Buryat Mongol BC patient.
|
31273614 |
2019 |
|
rs1216516227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Initial screening revealed pathogenic variants in known cancer genes, including <i>BARD1</i>:p.Trp91* detected in a cancer-free individual, and <i>MEN1</i>:p.Glu260Lys detected in a BC patient.
|
31681433 |
2019 |
|
rs121913529
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer.
|
30876538 |
2019 |
|
rs1264308
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four independent SNPs associated with BC risk, BIVM-ERCC5 rs1323697_C (OR = 1.06, 95% CI = 1.03-1.10), GTF2H4 rs1264308_T (OR = 0.93, 95% CI = 0.89-0.97), COPS2 rs141308737_C deletion (OR = 1.06, 95% CI = 1.03-1.09) and ELL rs1469412_C (OR = 0.93, 95% CI = 0.90-0.96).
|
31026346 |
2019 |
|
rs1264457
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The main objective of the study is to evaluate the impact of three <i>HLA-G</i> 3'UTR potential polymorphisms: +3187 A > G (rs9380142), +3142 G > C (rs1063320), +2960 14-base pair (bp) Insertion/Deletion (Ins/Del) (rs66554220), and the HLA-E*01:01/01:03 A > G (rs1264457) polymorphism in Tunisian breast cancer population.
|
30945586 |
2019 |
|
rs1275678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For rs1275678 polymorphism, there was a significantly decreased risk of BC among elder patients (codominant: p = .017; dominant: p = .019; additive: p = .030; and allele: p = .029).
|
31286696 |
2019 |
|
rs13000023
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs4849887 was significantly associated with overall BC risk, and both rs2363956 and rs13000023 were associated with TNBC-specific risk, although none as strongly as the Duffy-null variant.
|
31356281 |
2019 |
|
rs13188458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analyses by body mass index, exercise, and dietary fat intake with combined phenotypes showed that genetically elevated IR was associated with greater breast cancer risk in overall obesity and inactive subgroups (single contributor: MTRR/LOC729506 rs13188458; HR = 2.21, 95% CI: 1.03-4.75).
|
31246991 |
2019 |
|
rs1323697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four independent SNPs associated with BC risk, BIVM-ERCC5 rs1323697_C (OR = 1.06, 95% CI = 1.03-1.10), GTF2H4 rs1264308_T (OR = 0.93, 95% CI = 0.89-0.97), COPS2 rs141308737_C deletion (OR = 1.06, 95% CI = 1.03-1.09) and ELL rs1469412_C (OR = 0.93, 95% CI = 0.90-0.96).
|
31026346 |
2019 |
|
rs13293512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analysis showed that rs</span>13293512 CC genotype was associated with an increased risk of BC in patients with negative estrogen receptor (adjusted OR = 2.39; 95% CI: 1.32-4.30; <i>P=</i>0.004), patients with negative progesterone receptor (adjusted OR = 1.92; 95% CI: 1.11-3.33; <i>P=</i>0.02), patients with T1-2 stage cancer (adjusted OR = 1.77; 95% CI: 1.07-2.93; <i>P=</i>0.03), and patients with N1-3 stage cancer (adjusted OR = 1.89; 95% CI: 1.13-3.17; <i>P=</i>0.015).
|
31028134 |
2019 |
|
rs13431652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In phenotype-specific analysis, genetically elevated FG was associated with reduced risk for breast cancer (main contributor of this MR-effect estimate: G6PC2 rs13431652; HR = 0.59, 95% CI: 0.35-0.99).
|
31246991 |
2019 |
|
rs13447455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, results from the Breast Cancer Association Consortium show a marginal association between rs13447455 and breast cancer risk (p=9.3x10<sup>-5</sup>), thus warranting further investigation.
|
30823486 |
2019 |
|
rs139379666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a missense variant (rs139379666, P2974L; AF = 0.09% for breast cancer cases, but none for controls) in the <i>ATM</i> gene for breast cancer risk using combing data from 7,204 breast cancer cases and 9,593 controls (<i>P</i> = 1.7 × 10<sup>-5</sup>).
|
31160347 |
2019 |
|
rs140979078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Breast cancer-derived T58A MYC mutations are unable to activate Bim due to their failure to regulate p14/p21.
|
30655867 |
2019 |
|
rs141308737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four independent SNPs associated with BC risk, BIVM-ERCC5 rs1323697_C (OR = 1.06, 95% CI = 1.03-1.10), GTF2H4 rs1264308_T (OR = 0.93, 95% CI = 0.89-0.97), COPS2 rs141308737_C deletion (OR = 1.06, 95% CI = 1.03-1.09) and ELL rs1469412_C (OR = 0.93, 95% CI = 0.90-0.96).
|
31026346 |
2019 |
|
rs145204276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs145204276 del allele might protect against the development of BC via inducing the promoter activity by binding to transcriptional factor specificity protein 1, and finally resulting in higher levels of GAS5.
|
30846409 |
2019 |
|
rs1453633223
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Breast cancer-derived T58A MYC mutations are unable to activate Bim due to their failure to regulate p14/p21.
|
30655867 |
2019 |
|
rs1469412
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four independent SNPs associated with BC risk, BIVM-ERCC5 rs1323697_C (OR = 1.06, 95% CI = 1.03-1.10), GTF2H4 rs1264308_T (OR = 0.93, 95% CI = 0.89-0.97), COPS2 rs141308737_C deletion (OR = 1.06, 95% CI = 1.03-1.09) and ELL rs1469412_C (OR = 0.93, 95% CI = 0.90-0.96).
|
31026346 |
2019 |
|
rs147574894
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant association of rs3774937 and rs147574894 genotypes with breast cancer was seen under the dominant model.
|
30027470 |
2019 |