|
rs104894103
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CoQ10 deficiency has been identified in fibroblasts and muscle of AOA1 patients carrying the common W279X mutation, and aprataxin has been localized to mitochondria in neuroblastoma cells, where it enhances preservation of mitochondrial function.
|
25976310 |
2015 |
|
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.
|
25536437 |
2015 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analysis revealed that rs1052133</span> GC/CC carriers were less likely to develop neuroblastoma in subgroups of age >18 months, males, tumor that develops from retroperitoneal, mediastinum and clinical stage I+II+4s.
|
30519358 |
2018 |
|
rs1052536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that rs1052536 C>T and rs4796030 A>C are unrelated to neuroblastoma susceptibility in the Chinese population.
|
31737108 |
2019 |
|
rs1057519697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected the ALK mutation (F1174C and R1275Q) in 2 (3.7%) of the 54 NB specimens.
|
21940108 |
2011 |
|
rs1057520018
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A heterozygous missense mutation in STK11 (F354L) was identified in both the NB and FVPTC.
|
25751324 |
2015 |
|
rs1059111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The neurofilament gene NEFL harbored three SNPs associated with neuroblastoma (rs11994014: Pcombined = 0.0050; OR, 0.88; rs2979704: Pcombined = 0.0072; OR, 0.87; rs1059111: Pcombined = 0.0049; OR, 0.86).
|
25312269 |
2014 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
<b>Objective:</b> We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified <i>LMO1</i> variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
|
30406033 |
2018 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model.
|
31830377 |
2020 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In a combination analysis using Southern and Northern Chinese populations, we found that those carrying the rs110419 G, rs4758051 A or rs10840002 G allele were at decreased neuroblastoma risk, and this finding was supported by a false-positive report probability analysis.
|
29029458 |
2017 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility.
|
27009839 |
2016 |
|
rs10895322
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we identify common variants at 11q22.2 within MMP20 that associate with neuroblastoma cases harboring 11q deletion (rs10895322), using GWAS in 113 European-American cases and 5109 ancestry-matched controls.
|
28924153 |
2017 |
|
rs11037575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we verified that the <i>HSD17B12</i> rs11037575 T allele might negatively associate with neuroblastoma risk.
|
28435286 |
2017 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our findings revealed that rs110419 and rs2168101 polymorphisms were significantly associated with a decreased risk of NB in all genetic models.
|
31830377 |
2020 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We found that the rs110419 A > G polymorphism was associated with a significantly decreased neuroblastoma</span> risk (AG vs. AA: adjusted OR = 0.65, 95% CI = 0.47-0.91; GG vs. AA: adjusted OR = 0.58, 95% CI = 0.36-0.91; AG/GG vs. AA: adjusted OR = 0.63, 95% CI = 0.46-0.86), and the protective effect was more predominant in children of age > 18 months, males, subgroups with tumor in adrenal gland and mediastinum, and patients in clinical stages III/IV.
|
27009839 |
2016 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
<b>Results:</b> Significant associations with neuroblastoma risk were found for four (rs110419, rs4758051, rs10840002, and rs2168101) out of the five polymorphisms.
|
30406033 |
2018 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We also confirmed that rs6939340 A>G (G versus A: OR=1.30, 95% CI=1.13-1.50) and rs110419 G>A (A versus G: OR=1.37, 95% CI=1.19-1.58) were associated with increased neur</span>oblastoma risk for all subjects.
|
29024823 |
2017 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A major haplotype, ATC, containing rs204926, rs110420, and rs110419, conferred a significant increase in risk for NB (OR = 1.82, 95% CI: 1.41-2.36, adjusted P < 0.001).
|
26030754 |
2015 |
|
rs110420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A major haplotype, ATC, containing rs204926, rs110420, and rs110419, conferred a significant increase in risk for NB (OR = 1.82, 95% CI: 1.41-2.36, adjusted P < 0.001).
|
26030754 |
2015 |
|
rs11103603
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Maternal rs6776706 was associated with (RR: 0.49; 95% CI: 0.33-0.72, Q = 0.161) high-risk neuroblastoma and maternal rs11103603 (RR: 0.60; 95% CI: 0.45-0.79, Q = 0.127) was associated with neuroblastoma aged <1 year.
|
31279991 |
2019 |
|
rs11134527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, the miR-34b/c rs4938723 T > C and miR-218 rs11134527 A > G polymorphisms displayed a protective role from neuroblastoma.These findings need further validation.
|
29858046 |
2018 |
|
rs11247957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China.
|
31747721 |
2020 |
|
rs1130409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we conducted a three-center case-control study to evaluate the association between <i>APEX1</i> polymorphisms (rs1130409 T>G, rs1760944 T>G, and rs3136817 T>C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls.
|
31341530 |
2019 |
|
rs1131691014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we confirmed that miR-34b/c rs4938723 and TP53 Arg72Pro conferred decreased neuroblastoma risk and two polymorphisms exerted stronger protective effects against neuroblastoma than either one alone.
|
31325764 |
2019 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the mutation frequencies of BRAF(V600E) (V-raf murine sarcoma virus oncogene homolog B1) and NRAS (neuroblastoma ras viral oncogene homolog) codon 61 in CMNs of Chinese, we selected 55 paraffin-embedded tissue blocks, including 37 cases of medium CMNs (1.5-20cm) and 18 cases of giant CMNs (>20 cm).
|
21430505 |
2011 |