|
rs17069665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effects of rs17</span>069665 on ALL risk were more predominant in males and children < 10 years, and patients with lower rates of platelet or neutrophil.
|
31691337 |
2020 |
|
rs9400241
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs17069665 related to the increased ALL risk (OR = 1.76; 95% CI = 1.02-3.04), rs9400241 related to decreased ALL risk (OR = 0.80; 95% CI = 0.64-0.99).
|
31691337 |
2020 |
|
rs111978267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined whether the common IKZF1 polymorphisms rs4132601 T/G and rs111978267 A/G are associated with ALL among a Tunisian pediatric cohort.
|
31604453 |
2019 |
|
rs2043211
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, NF-κB-94 ins/del ATTG and CARD8 (rs2043211) genotypes might serve as novel biomarkers and potential targets for ALL.
|
31428046 |
2019 |
|
rs2413739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to validate the impact of the single-nucleotide polymorphism rs2413739 (T > C) in the PACSIN2 gene on thiopurines pharmacological parameters and clinical response in an Italian cohort of pediatric patients with acute lymphoblastic leukemia (ALL) and inflammatory bowel disease (IBD).
|
31792371 |
2019 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
|
30576465 |
2019 |
|
rs3758149
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the role of rs3758149 C/T polymorphism and transcription factors in the regulation of <i>GGH</i> expression in human acute lymphoblastic leukemia (ALL) CEM/C1 cells.
|
31739835 |
2019 |
|
rs57095329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
|
30576465 |
2019 |
|
rs7089424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CAG haplotype (rs10821936, rs10994982, rs7089424) was strongly associated with ALL risk in our population (p < 0.00001).
|
31227872 |
2019 |
|
rs1188383936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Samples collected prior to the start of ALL therapy were evaluated for genetic and acquired PDs (proteins C and S, antithrombin, procoagulant factors VIII (FVIII:C), IX, XI and von Willebrand factor antigen levels, gene polymorphisms of factor V G1691A, prothrombin gene G20210A and methylene tetrahydrofolate reductase C677T, anticardiolipin antibodies, fasting lipoprotein(a), and homocysteine).
|
29334169 |
2018 |
|
rs12402181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12402181 in miR-3117 and rs62571442 in miR-3689d2 were associated with ALL risk in both cohorts, possibly through their effect on MAPK signalling pathway.
|
29796161 |
2018 |
|
rs153109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the association of IL-27 rs153109 and rs17855750 polymorphisms with risk of ALL development and their impact on EFS suggested an important role for this cytokine in biology and response to ALL therapy.
|
28828696 |
2018 |
|
rs17855750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the association of IL-27 rs153109 and rs17855750 polymorphisms with risk of ALL development and their impact on EFS suggested an important role for this cytokine in biology and response to ALL therapy.
|
28828696 |
2018 |
|
rs2069762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this work was to explore the association of IFNG +874 A/T (rs2430561) and IL2 -330 G/T (rs2069762) SNPs with ALL susceptibility and/or protection in 488 Mexican Mestizos patients, as compared to 950 Mexican Mestizo healthy controls.
|
30212785 |
2018 |
|
rs2430561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this work was to explore the association of IFNG +874 A/T (rs2430561) and IL2 -330 G/T (rs2069762) SNPs with ALL susceptibility and/or protection in 488 Mexican Mestizos patients, as compared to 950 Mexican Mestizo healthy controls.
|
30212785 |
2018 |
|
rs3731249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we conducted a systematic review and meta-analysis to re-evaluate the association of both SNPs (rs3731217 and rs3731249) with ALL susceptibility by gathering the data from 24 independent studies, totally containing 7922 cases/21503 controls for rs3731217 and 6295 cases/24191 controls for rs3731249.
|
29654170 |
2018 |
|
rs4149009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping for SLCO1A2 rs4149009 G > A in 141 children with ALL was performed using the Sequenom MassARRAY system.
|
29306656 |
2018 |
|
rs4646450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP3A5 rs4646450 TT was 17% among ALL cases with FS lower than 28, and 3% in ALL patients without pathological FS (p = 5.60E-03; OR = 6.94 (1.76-27.39)).
|
29970035 |
2018 |
|
rs62571442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12402181 in miR-3117 and rs62571442 in miR-3689d2 were associated with ALL risk in both cohorts, possibly through their effect on MAPK signalling pathway.
|
29796161 |
2018 |
|
rs755622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of the present study indicate that the MIF-173G/C (rs755622) polymorphism is a risk factor for childhood ALL development with respect to both homozygous and combined polymorphic genotypes.
|
29996006 |
2018 |
|
rs7853758
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC28A3 rs7853758 AA was 12% in ALL cases population, while only 1% among controls (p = 6.50E-03; OR = 11.56 (1.98-67.45)).
|
29970035 |
2018 |
|
rs885822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variation in rs885822 was found to be associated with overall survival: patients carrying the GG genotype demonstrated a significantly increased risk of death compared to those carrying the A allele, independently of ALL risk groups (HR 3.13, 95%CI 1.16-7.8, p = 0.014).
|
29304394 |
2018 |
|
rs10235796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IKZF1 SNPs, rs10235796 and rs6964969, and the CDKN2A SNP rs3731246 (previously unreported) could serve as risk markers for ALL susceptibility in Yemeni children.
|
28768142 |
2017 |
|
rs12434881
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No associations were found between the IKZF1 SNPs (rs11978267; rs7789635), DDC SNPs (rs3779084; rs880028; rs7809758), CDKN2A SNP (rs3731217), the CEBPE SNPs (rs2239633; rs12434881) and LMO1 SNPs (rs442264; rs3794012; rs4237770) with ALL in Yemeni children.
|
28768142 |
2017 |
|
rs35134728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping for MTHFR rs3737966 and rs35134728 in 144 children with ALL was performed using the Sequenom MassArray system (Sequenom, San Diego, CA, USA).
|
28990296 |
2017 |