|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL).
|
22943282 |
2012 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL).
|
22943282 |
2012 |
|
rs1695
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A combination between GSTM1 double-null genotype and rs1695 also showed an association with ALL (P=0.042).
|
27299594 |
2016 |
|
rs569954362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A high-abundance C/T696 polymorphism was detected with nearly identical frequencies for both alleles, and a heterozygous C/A1242 sequence variant was identified in two ALL specimens.
|
11705857 |
2001 |
|
rs57725551
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A high-abundance C/T696 polymorphism was detected with nearly identical frequencies for both alleles, and a heterozygous C/A1242 sequence variant was identified in two ALL specimens.
|
11705857 |
2001 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
|
16897583 |
2006 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
|
16897583 |
2006 |
|
rs138047632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A missense mutation affecting the 11th transmembrane domain of RFC (c.1250T>C; p.I417T) was found in one case of ALL at diagnosis.
|
18028428 |
2008 |
|
rs7088318
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A novel ALL susceptibility locus at 10p12.31-12.2 (BMI1-PIP4K2A, rs7088318, P = 1.1 × 10(-11)) was identified in the genome-wide association study, with independent replication in European Americans, African Americans, and Hispanic Americans (P = .001, .009, and .04, respectively).
|
23512250 |
2013 |
|
rs1800460
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A patient, exhibiting neutropenia on 6-MP was observed to be G460A-homozygote, while, two Acute Lymphoblastic Leukemia (ALL) patients with side-effects exhibited wild-type alleles.
|
20037211 |
2009 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Accumulated evidence has demonstrated that C677T and A1298C polymorphisms of the MTHFR gene are associated with acute lymphoblastic leukemia (ALL) risk, but the results have been inconclusive.
|
21702646 |
2011 |
|
rs11545078
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Allelic frequency of GGH 452C→T polymorphism was determined as 9.2% (CT, 11/71; TT, 1/71) in the ALL group, 8.0% (CT, 4/25; TT, 0/25) in the AML group, and 9.1% (TT, 4/132; T/C, 16/132) in the controls, respectively.
|
22568793 |
2012 |
|
rs6461639
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among them, rs6461639 (interaction P=1.88 × 10<sup>-5</sup> in the CAMP population) showed a significant association with the final BMD Z-scores in the ALL population (P=0.016).
|
26856247 |
2017 |
|
rs1057519743
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
rs7039798
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analysis revealed 3 of 6 SNPs to confer significant increase in ALL risk these being rs7039798 (p= 0.014, OR=2.14), rs1544105 (p=0.010, OR= 2.24), and rs10106 (p=0.026, OR= 1.99).
|
26107232 |
2015 |
|
rs2735383
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Besides, there is no report about the association between NBS1 3'UTR variant rs2735383 and ALL risk.
|
21166880 |
2011 |
|
rs3733890
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BHMT (rs3733890) polymorphism showed no association with ALL.
|
28582843 |
2017 |
|
rs924607
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Bioinformatics tools and the implementation of artificial i Lack of association of the CEP72 rs924607 TT genotype with intelligence are expected to open the door wide for personalized medicine in the clinical practice of childhood ALL.
|
30832275 |
2019 |
|
rs368939818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs755001634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs757891309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs1039659576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs1448674651
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs1979277
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs201765376
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |