|
rs10106
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggested that common genetic polymorphisms in the FPGS coding region including rs7039789, rs1544105, and rs10106 are significantly associated with increased ALL risk in Thai children.
|
26107232 |
2015 |
|
rs10235796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IKZF1 SNPs, rs10235796 and rs6964969, and the CDKN2A SNP rs3731246 (previously unreported) could serve as risk markers for ALL susceptibility in Yemeni children.
|
28768142 |
2017 |
|
rs1039659576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the first time, we associate the RFC1 80G>A and NNMT IVS -151C>T variants to an increased ALL susceptibility.
|
19020309 |
2009 |
|
rs1039659576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs1042522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) genes may contribute to susceptibility to childhood ALL because they affect some important processes, such as metastasis regulation and tumor suppression.
|
23653000 |
2013 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our results suggest that C3435T polymorphism in MDR1 gene is not a major prognosticator in adult ALL.
|
16382213 |
2006 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians.
|
25661341 |
2015 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL.
|
23244145 |
2012 |
|
rs104893636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The p.Glu81Val mutation of HOXD4 thus results in a partial loss-of-function, which might be involved in childhood ALL.
|
15776434 |
2005 |
|
rs1051296
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping for SLC19A1 rs1051296 G>T in 131 children with ALL was performed using the Sequenom MassArray system.
|
24927955 |
2014 |
|
rs10519612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed a higher risk of developing ALL for rs10519612 CC, rs17007695 TC and rs17007695 CC genotype carriers.
|
24689757 |
2015 |
|
rs1057519743
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
rs1057519866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we present kinetic and structural properties of cN-II variants that represent 75 % of mutated alleles in patients who experience relapsed ALL (R367Q, R238W and L375F).
|
27756303 |
2016 |
|
rs10821936
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |
|
rs10821936
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the studied Egyptian population, it can be concluded that the C allele, CC, and CT genotypes of <i>ARID5B</i> rs10821936 and the CA haplotype may be a susceptibility risk factor for pediatric and adult ALL.
|
31424309 |
2019 |
|
rs10828317
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs10828317 association was shown to be specifically associated with hyperdiploid ALL, whereas the rs3824662-associated risk was confined to nonhyperdiploid non-TEL-AML1 + ALL.
|
23996088 |
2013 |
|
rs10994982
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |
|
rs10994982
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The CAG haplotype (rs10821936, rs10994982, rs7089424) was strongly associated with ALL risk in our population (p < 0.00001).
|
31227872 |
2019 |
|
rs10994982
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, the SNPs of <i>ARID5B</i> rs10821936 and rs10994982</span> were not found to be strongly associated with ALL outcomes.
|
31424309 |
2019 |
|
rs11099592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant correlation was found between rs11099592 and rs6535455 heparanase gene (HPSE) single nucleotide polymorphisms (SNPs) and ALL (chi2(1d.f.)=4.96, P=0.026).
|
17611567 |
2007 |
|
rs111033563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |
|
rs111978267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined whether the common IKZF1 polymorphisms rs4132601 T/G and rs111978267 A/G are associated with ALL among a Tunisian pediatric cohort.
|
31604453 |
2019 |
|
rs1127354
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, we recently studied the effects of a common polymorphism in another gene encoding an enzyme involved in mercaptopurine metabolism (SNP rs1127354 in inosine-triphospate-pyrophosphatase, ITPA), showing that genetic polymorphism of ITPA is a significant determinant of mercaptopurine metabolism and of febrile neutropenia following combination chemotherapy of acute lymphoblastic leukemia (ALL) in which mercaptopurine doses are individualized based on TPMT genotype.
|
20021291 |
2010 |
|
rs1127354
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aims of this study were to (a) to determine the prevalence of seven common genetic polymorphisms including those that affect the folate and/or thiopurine metabolic pathways, i.e. cyclin D1 (CCND1-G870A), γ-glutamyl hydrolase (GGH-C452T), methylenetetrahydrofolate reductase (MTHFR-C677T and MTHFR-A1298C), thymidylate synthase promoter (TYMS-TSER), thiopurine methyltransferase (TPMT*3A and TPMT*3C) and inosine triphosphate pyrophosphatase (ITPA-C94A), in Caucasian (n = 94, age < 20) and Vietnamese (n = 141, age < 16 years) childhood ALL and (b) to assess the impact of a multilocus genetic risk score (MGRS) on relapse-free survival (RFS) using a Cox proportional-hazards regression model.
|
25099492 |
2015 |