|
rs2072590
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The OC risk-associated SNP rs2072590 lies in non-coding DNA downstream of <i>HOXD3</i> and upstream of <i>HOXD1</i>, and it tags SNPs in the <i>HOXD3</i> 3' UTR.
|
29262571 |
2017 |
|
rs2072590
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs2072590
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
|
20852632 |
2010 |
|
rs10069690
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A splicing variant in TERT, rs10069690, showed a statistically significant interaction with ET use for risk of serous ovarian cancer (p<sub>int</sub> = 0.013).
|
27420401 |
2016 |
|
rs10069690
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
|
28346442 |
2017 |
|
rs10088218
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs10088218
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
|
rs10088218
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
|
20852632 |
2010 |
|
rs104886003
|
|
A |
0.710 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs104886003
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We also found that an activating (E545K) Pik3ca mutation, unlike Pten inactivation or Pik3ca H1047R mutation, cannot cooperate with Arid1a loss to promote ovarian cancer development in the mouse.
|
26279473 |
2016 |
|
rs11651755
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
|
28346442 |
2017 |
|
rs11651755
|
|
|
0.710 |
GeneticVariation |
BEFREE |
As rs11651755 in HNF1B modified both the ovarian cancer risk and also the risk for endometriosis, HNF1B may be causally involved in the pathogenetic pathway leading from endometriosis to ovarian cancer.
|
28214017 |
2017 |
|
rs121913279
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We also found that an activating (E545K) Pik3ca mutation, unlike Pten inactivation or Pik3ca H1047R mutation, cannot cooperate with Arid1a loss to promote ovarian cancer development in the mouse.
|
26279473 |
2016 |
|
rs121913343
|
|
A |
0.710 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs121913343
|
|
C |
0.710 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs121913343
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We present the apparent BRCA1-related, although mutation negative, breast and ovarian cancer patient who subsequently was confirmed to be TP53 c.817C>T (p.R273C) mutation carrier and discuss the importance of peri-diagnostic oncogenetic TP53 testing in early breast cancer cases.
|
21535297 |
2011 |
|
rs121913529
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer.
|
21632463 |
2011 |
|
rs2363956
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs2363956
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Common variants at 19p13 are associated with susceptibility to ovarian cancer.
|
20852633 |
2010 |
|
rs2665390
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
|
20852632 |
2010 |
|
rs2665390
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs397516436
|
|
|
0.710 |
GeneticVariation |
BEFREE |
High prevalence of codon 213Arg-->Stop mutations of the TP53 gene in human ovarian cancer in the southwestern part of The Netherlands.
|
9579562 |
1998 |
|
rs41293459
|
|
T |
0.710 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs41293459
|
|
|
0.710 |
GeneticVariation |
BEFREE |
BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk.
|
22889855 |
2012 |
|
rs8037137
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3).
|
27432226 |
2016 |