|
rs1972597
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients.
|
27670397 |
2016 |
|
rs3862188
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients.
|
27670397 |
2016 |
|
rs180127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This pilot study provides preliminary evidence supporting genetic variation of EGFR (rs2227983), KRAS (rs61764370) and FCGR2A (rs180127) as useful biomarkers for predicting reduced skin toxicity in HNSCC patients treated with a cetuximab-based therapy.
|
27938998 |
2016 |
|
rs229811
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of OX40 gene polymorphisms (rs17568G/A and rs229811A/C) with head and neck squamous cell carcinoma.
|
30923998 |
2019 |
|
rs7834169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An upstream variant of MIR548H4 (rs7834169), replicated its association with overall HNSCC risk as well as risk of oral cavity cancer.
|
28582492 |
2017 |
|
rs874945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there were no significant associations of rs874945 and rs7958904 with HNSCC risk.
|
29461598 |
2018 |
|
rs1034220998
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs368731455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
XPD c.934G>A polymorphism of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation.
|
26918827 |
2017 |
|
rs758821654
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs765693356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs1229984
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [G-->A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [C-->G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN).
|
20336794 |
2010 |
|
rs1229984
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two SNPs were associated with SCCHN risk: ADH1B rs1229984 A allele (OR = 0.7; 95% CI, 0.6-0.9) and ALDH2 rs2238151 C allele (OR = 1.2; 95% CI, 1.1-1.4).
|
21940907 |
2011 |
|
rs1229984
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ADH1B histidine allele (rs1229984), CYP2E1 rs3813867 heterozygous genotype, and GSTT1 deletion conferred protection against HNSCC (OR: 0.318 [0.04-0.75], OR: 0.13 [0.02-0.94], and OR: 0.12 [0.02-0.60], respectively) while GSTP1 (rs1695) Val/Val genotype was related to an increased risk (OR: 4.12 [1.11-15.31]).
|
25639971 |
2015 |
|
rs1573496
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations.
|
20336794 |
2010 |
|
rs2238151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs were associated with SCCHN risk: ADH1B rs1229984 A allele (OR = 0.7; 95% CI, 0.6-0.9) and ALDH2 rs2238151 C allele (OR = 1.2; 95% CI, 1.1-1.4).
|
21940907 |
2011 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present data suggest a possible interaction between the ALDH2 1510 G/A polymorphism and age in HNSCC.
|
17033202 |
2006 |
|
rs26537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, we identified that rs26537 of ATG12 (additive model: adjusted odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.03-1.37, P = 0.017) and rs4663402 in ATG16L1 (additive model: adjusted OR = 1.39, 95%CI = 1.08-1.80, P = 0.010) were significantly associated with the increased risk of HNSCC.
|
29637616 |
2018 |
|
rs1130409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings indicated that a significantly decreased risk of SCCHN was associated with the ADPRT 762Ala/Ala genotype (adjusted odds ratio [OR], 0.51; 95% confidence interval [95% CI], 0.27-0.97) and the combined ADPRT 762Ala/Val and Ala/Ala genotypes (OR, 0.79; 95% CI; 0.63-1.00) compared with the ADPRT 762Val/Val genotype, but no altered risk was associated with the XRCC1 Arg399Gln or APE Asp148Glu polymorphisms, and no evidence of interactions was observed between the 3 selected SNPs and age, sex, smoking status, drinking status, or tumor site.
|
17614107 |
2007 |
|
rs4663402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, we identified that rs26537 of ATG12 (additive model: adjusted odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.03-1.37, P = 0.017) and rs4663402 in ATG16L1 (additive model: adjusted OR = 1.39, 95%CI = 1.08-1.80, P = 0.010) were significantly associated with the increased risk of HNSCC.
|
29637616 |
2018 |
|
rs2273535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Aurora-Kinase A Phe31-Ile polymorphism as possible predictor of response to treatment in head and neck squamous cell carcinoma.
|
29560108 |
2018 |
|
rs1257821596
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations.
|
20336794 |
2010 |
|
rs1023835002
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs1023835002
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs1057519877
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs1057519879
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |