rs28934576
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results show: (1) wild-type p53 stimulates the transcription of reporter genes with p53CON and RGC in their 5' region while most p53 mutants occurring in human cancers have lost this activity; (2) the R273H mutant retains transcriptional activity for the p53CON sequence but not RGC; (3) some mutants are temperature-sensitive for the transcriptional activity with the p53CON but not the RGC sequence; (4) p53 mutants vary in their ability to inhibit wild-type p53 transactivation but there is no difference between p53CON and RGC sequences; (5) lung cancer cells with endogenous mutant p53 proteins (M246I in H23 cells and R248L in H322 cells) retain transcriptional activity for the p53CON but not the RGC sequence.
|
8336941 |
1993 |
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show: (1) wild-type p53 stimulates the transcription of reporter genes with p53CON and RGC in their 5' region while most p53 mutants occurring in human cancers have lost this activity; (2) the R273H mutant retains transcriptional activity for the p53CON sequence but not RGC; (3) some mutants are temperature-sensitive for the transcriptional activity with the p53CON but not the RGC sequence; (4) p53 mutants vary in their ability to inhibit wild-type p53 transactivation but there is no difference between p53CON and RGC sequences; (5) lung cancer cells with endogenous mutant p53 proteins (M246I in H23 cells and R248L in H322 cells) retain transcriptional activity for the p53CON but not the RGC sequence.
|
8336941 |
1993 |
rs1019340046
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results show: (1) wild-type p53 stimulates the transcription of reporter genes with p53CON and RGC in their 5' region while most p53 mutants occurring in human cancers have lost this activity; (2) the R273H mutant retains transcriptional activity for the p53CON sequence but not RGC; (3) some mutants are temperature-sensitive for the transcriptional activity with the p53CON but not the RGC sequence; (4) p53 mutants vary in their ability to inhibit wild-type p53 transactivation but there is no difference between p53CON and RGC sequences; (5) lung cancer cells with endogenous mutant p53 proteins (M246I in H23 cells and R248L in H322 cells) retain transcriptional activity for the p53CON but not the RGC sequence.
|
8336941 |
1993 |
rs587781991
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the ability of human lung cancer cells to adequately process and present a mutant p53-derived CTL epitope, we transfected the human cell line HMy-2.C1R and the p53-null human lung cancer cell lines H358 and H1299 with an expression vector containing a human mutant p53 (135 Cys to Tyr).
|
9816244 |
1996 |
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, this study gives support to the value of the cytochrome P450 IA1 Ile462Val polymorphism as a practical high-risk marker of lung cancer in populations, especially those in southeast Asia, in which this variant is more common.
|
9610791 |
1998 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We, therefore, examined allele distributions of the Ser326Cys polymorphism in a case-control study of male lung cancer in Okinawa.
|
10744126 |
1999 |
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we have addressed the possible role of the Ile105Val GSTP1 polymorphism in lung cancer susceptibility.
|
10334644 |
1999 |
rs28934576
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1.
|
10226602 |
1999 |
rs1174612410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1.
|
10226602 |
1999 |
rs774352237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1.
|
10226602 |
1999 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The amino acid replacement of arginine by proline at codon 72 of TP53 appears not to be important in determining lung cancer risk in this population.
|
11097227 |
2000 |
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between Japanese and Caucasian populations, the I462V polymorphism is not related to lung cancer overall, but it might play a role at lower levels of cigarette smoking among subjects with impaired carcinogen detoxification as assessed by the GSTM1-null genotype.
|
11008920 |
2000 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The amino acid replacement of arginine by proline at codon 72 of TP53 appears not to be important in determining lung cancer risk in this population.
|
11097227 |
2000 |
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The amino acid replacement of arginine by proline at codon 72 of TP53 appears not to be important in determining lung cancer risk in this population.
|
11097227 |
2000 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we found no evidence for an association between the MTHFR C677T and A1298C polymorphisms and risk of lung cancer in either all of the subjects or the low folate intake subgroup; nor did we find evidence for an interaction between these two MTHFR polymorphisms and dietary folate intake or alcohol use.
|
11319182 |
2001 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Conversely, individuals with the variant Arg194Trp allele who were alcohol drinkers seemed to be at lower risk for lung cancer compared with those with the homozygous wild-type genotype.
|
11219768 |
2001 |
rs1799793
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We therefore examined XPD polymorphisms at Lys751Gln and Asp312Asn in 341 white lung cancer cases and 360 age-, sex-, ethnicity-, and smoking-matched controls accrued in a hospital-based molecular epidemiological study of susceptibility markers for lung cancer.
|
11245433 |
2001 |
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, individuals with the variant Arg280His allele who were alcohol drinkers seemed to be at higher risk for lung cancer compared with those with the homozygous wild-type genotype.
|
11219768 |
2001 |
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
However, we found no evidence for an association between the MTHFR C677T and A1298C polymorphisms and risk of lung cancer in either all of the subjects or the low folate intake subgroup; nor did we find evidence for an interaction between these two MTHFR polymorphisms and dietary folate intake or alcohol use.
|
11319182 |
2001 |
rs369576054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional characterization of naturally occurring mutants (P405R and P425L) of p73alpha and p73beta found in neuroblastoma and lung cancer.
|
11429704 |
2001 |
rs538874513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional characterization of naturally occurring mutants (P405R and P425L) of p73alpha and p73beta found in neuroblastoma and lung cancer.
|
11429704 |
2001 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk.
|
11927502 |
2002 |
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The odds ratio (OR) of lung cancer for the variant CYP1A1 Ile(462)Val polymorphism (Ile/Val, Val/Val) was 2.99 [95% confidence interval (95%CI) 1.51-5.91]; this effect was stronger on lung adenocarcinoma (OR 4.85, 95%CI 2.03-11.6).
|
12771031 |
2003 |
rs13181
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have described statistically significant interactions between the ERCC2 polymorphisms (Asp312Asn and Lys751Gln) and smoking in lung cancer risk.
|
12692111 |
2003 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the Arg194Trp</span> vari</span>ant reduced the risk of lung cancer associated with increased serum carotenoids compared to those with the homozygous wild-type allele.
|
12680158 |
2003 |