|
rs1045411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold).
|
29104475 |
2017 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association of MDR1 gene (C3435T) polymorphism and gene expression profiling in lung cancer patients treated with platinum-based chemotherapy.
|
26288241 |
2015 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; CYP2A6 -47A>C; MDR1 3435T>C; NAT1 1088T>A and 1095A>C; GSTA2 S112T; GSTM3 V224I and MTHFR A222V had altered risk of developing lung cancer.
|
17259654 |
2007 |
|
rs1046175
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aims to explore the relationship between SFTPB rs7316, rs9752 and PAOX rs1046175 gene polymorphisms and the diagnostic value of plasma Pro-SFTPB and DAS in patients with Chinese Han lung cancer.
|
31016788 |
2019 |
|
rs1046282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype ERCC2 rs3916874(G) and rs238415(C) [OR (95% CI)=1.26 (1.02-1.57), P=0.03] in block 1 and the haplotype PPP1R13L rs4803817(A), CD3EAP rs1046282(T), rs735482(C), ERCC1 rs3212980(A), rs3212964(G) [OR (95% CI)=3.56 (1.55-8.18), P=0.005] in block 3 were associated with lung cancer risk.
|
24140460 |
2013 |
|
rs1047768
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a stratified analysis, rs1047768 T>C was associated with an increased risk of lung cancer, rs2227869 G>C was associated with a decreased risk of cancer in population-based studies, and rs751402 C>T and rs873601 G>A were associated with the risk of gastric cancer.
|
28416771 |
2017 |
|
rs1047840
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis suggests, for the first time, that the EXO1 Glu589Lys polymorphism is not associated with overall cancer susceptibility, although marginal associations were found for lung cancer and Asian subgroups.
|
24761866 |
2014 |
|
rs1047840
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results suggest that the EXO1 Glu589Lys polymorphism and its surrounding regions might be genetic susceptibility markers for lung cancer in this study population.
|
18079015 |
2008 |
|
rs1047840
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results provide the first evidence that the A allele of Exo1 K589E may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.
|
19331228 |
2009 |
|
rs1047972
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant allele of Val57Ile was not associated with lung cancer risk overall.
|
16926177 |
2007 |
|
rs1047972
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that STK15 F31I polymorphism is associated with increased breast cancer and ovarian cancer risk among Caucasians, F31I polymorphism is associated with decreased lung cancer risk among Caucasians, and V57I polymorphism is associated with decreased breast cancer risk among Caucasians.
|
25154511 |
2015 |
|
rs10487372
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with 'deletion-T' (DeltaF508/rs10487372) haplotype had a 68% reduced risk for lung cancer compared to common haplotype 'no-deletion-C' (OR=0.32; 95% CI=0.15-0.68; p=0.01).
|
20116881 |
2010 |
|
rs104886003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, RNA profiling of lung epithelial cells (BEAS-2B) expressing a mutant allele of PIK3 (E545K) identified a network of transcription factors such as MYC, FOS and HMGA1, not previously recognised to be associated with aberrant PI3K signalling in lung cancer.
|
22363436 |
2012 |
|
rs104886026
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, to identify genetic factors that modify lung cancer risk, CHRNA5 non-synonymous variant amino acid position 398 (D398N) was identified.
|
19577767 |
2010 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were at decreased risk of having lung cancer compared to those with the lle/lle genotype, after adjusting for age at diagnosis, sex, pack years of smoking and family history of cancer (OR=0.41 95% Cl 0.19-0.90).
|
17174438 |
2007 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between Japanese and Caucasian populations, the I462V polymorphism is not related to lung cancer overall, but it might play a role at lower levels of cigarette smoking among subjects with impaired carcinogen detoxification as assessed by the GSTM1-null genotype.
|
11008920 |
2000 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies.
|
22025136 |
2011 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Neither CYP1A1 MspI nor CYP1A1 Ile(462)Val was associated with lung cancer susceptibility among Caucasians or African-Americans.
|
16051642 |
2005 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GSTM1 deletion polymorphism (OR = 1.38, 95% CI = 1.01-1.89), GSTP1 rs1695 (OR =1.48, 95% CI = 1.04-2.11), ERCC2 rs13181 (OR = 1.89, 95% CI = 1.28-2.78), and Chinese hamster 1 rs25487 (OR = 1.54, 95% CI = 1.12-2.13) were associated with lung cancer risk whereas the GSTT1 deletion polymorphism and XRCC3 rs861539 were not.
|
22525558 |
2012 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, this study gives support to the value of the cytochrome P450 IA1 Ile462Val polymorphism as a practical high-risk marker of lung cancer in populations, especially those in southeast Asia, in which this variant is more common.
|
9610791 |
1998 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An elevated risk of lung cancer was observed among individuals with the MspI CC (OR=1.7, 95 CI=0.9-3.3) and Ile(462)Val ValVal genotypes (OR=2.8, 95 CI=1.1-7.6).
|
15953982 |
2005 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the Ile462Val polymorphisms of CYP1A1 correlate with increased lung cancer susceptibility in Asian and Caucasian populations and there is an interaction with smoking status, but these associations vary in different histological types of lung caner.
|
22952673 |
2012 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further stratified analysis by cancer types revealed that the MspI polymorphism may increase the risk of lung cancer and cervical cancer whereas the Ile462Val polymorphism may contribute to a higher risk of lung cancer, leukemia, esophageal carcinoma, and prostate cancer.
|
24391993 |
2013 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results indicate that the CYP1A1*2B allele (rs4646903 and rs1048943) is associated with an increased lung cancer risk and CYP2A6*4 is associated with a decreased lung cancer risk in the study population.
|
23178447 |
2013 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of lung adenocarcinoma in never-smoking Korean women, whereas specific combinations of variant genotypes for metabolic enzymes increase lung cancer risk considerably.
|
17980933 |
2008 |