|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The presence of the G allele at rs10490924 in the ARMS2 gene is likely associated with a lower chance of retreatment after IVA+PDT in patients with PCV.
|
31376050 |
2019 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interaction analysis revealed the CFH SNP rs800292 has a highly significant interaction with the ANGPT2 SNP rs13269021 in nAMD and PCV in the combined analysis.
|
28192798 |
2017 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with GA were significantly older, with a higher prevalence of reticular pseudodrusen, bilateral involvement of advanced AMD and T-allele frequency of ARMS2 A69S compared with those with typical AMD and PCV; although there were no differences in the genetic and clinical characteristics among patients with GA and RAP.
|
26918864 |
2016 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Subfoveal choroidal thickness and CVH in eyes with treatment-naive polypoidal choroidal vasculopathy were associated with ARMS2 A69S (rs10490924) and CFH (rs1329428).
|
26745149 |
2016 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Development of PCV in the unaffected fellow eye is associated with ARMS2 A69S genotype in patients with unilateral PCV.
|
26332911 |
2016 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, the rs11200638-rs2672598 joint genotype AA-CC conferred higher risk to exudative AMD (43.11 folds) than PCV (3.68 folds).
|
27338780 |
2016 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After adjusting for age, gender, ARMS2 A69S, and CFHI62V, the A allele of rs429608 was significantly protective against neovascular AMD (odds ratio [OR] 0.24, 95% confidence interval [CI] 0.122-0.484, p < 0.001), PCV (OR 0.43, 95% CI 0.262-0.704, p = 0.001), RAP (OR 0.09, 95% CI 0.014-0.581, p = 0.011).
|
24865191 |
2014 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
FPR1 rs78488639 interacted with CFH rs800292, HTRA1 rs11200638, and smoking, enhancing risk to exudative AMD and PCV.
|
25277308 |
2014 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The variant of I62V could be a promising genetic biomarker of PCV in Asian populations.
|
24520367 |
2014 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
FPR1 rs78488639 interacted with CFH rs800292, HTRA1 rs11200638, and smoking, enhancing risk to exudative AMD and PCV.
|
25277308 |
2014 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant interaction between the CETP SNP rs3764261 and the CFH SNP rs800292 existed in both neovascular AMD and PCV, the rs800292 G allele conferring a significantly increased risk of the diseases only in individuals carrying the risk allele T of rs3764261.
|
24393350 |
2014 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After adjusting for rs11200638, ARMS2 rs10490924 remained significantly associated with nAMD and PCV (p<0.001).
|
23326481 |
2013 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our analysis provides evidence that the A69S variant is associated with an increased risk of PCV in Asian populations.
|
23697955 |
2013 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The minor allele frequency (MAF) of rs10490924 was significantly different between Type 1 PCV (n = 81) and control (p < 0.0001), while no difference was found between Type 2 PCV (n = 94) and control (p = 0.20).
|
23289808 |
2013 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After adjusting for rs11200638, ARMS2 rs10490924 remained significantly associated with nAMD and PCV (p<0.001).
|
23326481 |
2013 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MAF of rs800292 was significantly different between each type of PCV and control (p < 0.0001 and 0.0001 for Type 1 versus control and Type 2 versus control, respectively).
|
23289808 |
2013 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ARMS2 (rs10490924)/HTRA1 (rs11200638) variants are significantly associated with the risk of PCV in a Korean population.
|
21959923 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis showed consistent allelic associations of rs10490924 and rs11200638 with PCV in different study populations.
|
22491416 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
LOC387715 rs10490924 was associated with PCV and its clinical manifestations, and showed a discrepant distribution between PCV and AMD.
|
22509112 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies.
|
23315805 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an independent association of C2/CFB variants was found for both typical AMD and PCV with age, sex, smoking, and genetic background of ARMS2 A69S and CFH I62V (vs. typical AMD: P = 0.0073, odds ratio [OR] = 0.47; vs. PCV: P = 0.0083, OR = 0.53).
|
22232432 |
2012 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ARMS2 (rs10490924)/HTRA1 (rs11200638) variants are significantly associated with the risk of PCV in a Korean population.
|
21959923 |
2012 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant associations with both exudative AMD and PCV were observed in 11 of them and HTRA1 rs11200638, with different genotypic distributions between exudative AMD and PCV (P < 0.001).
|
22491416 |
2012 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
With meta-analyses, variants in four genes were found to be significantly associated with PCV: LOC387715 rs10490924 (n=9, allelic odds ratio [OR]=2.27, p<0.00001), HTRA1 rs11200638 (n=4, OR=2.72, p<0.00001), CFH rs1061170 (n=4, OR=1.72, p<0.00001), CFH rs800292 (n=5, OR=2.10, p<0.00001), and C2 rs547154 (n=3, OR=0.56, p=0.01).
|
22509112 |
2012 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
With meta-analyses, variants in four genes were found to be significantly associated with PCV: LOC387715 rs10490924 (n=9, allelic odds ratio [OR]=2.27, p<0.00001), HTRA1 rs11200638 (n=4, OR=2.72, p<0.00001), CFH rs1061170 (n=4, OR=1.72, p<0.00001), CFH rs800292 (n=5, OR=2.10, p<0.00001), and C2 rs547154 (n=3, OR=0.56, p=0.01).
|
22509112 |
2012 |