Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519897
rs1057519897
FGFR1
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs869320694
rs869320694
FGFR1
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913459
rs121913459
ABL1
T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913461
rs121913461
ABL1
C 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913459
rs121913459
ABL1
T 0.700 GeneticVariation CLINVAR MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. 22772060

2013
dbSNP: rs1057519721
rs1057519721
JAK2 ; INSL6
G 0.700 CausalMutation CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270

2012
dbSNP: rs1057519721
rs1057519721
JAK2 ; INSL6
G 0.700 CausalMutation CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920

2012
dbSNP: rs1057519722
rs1057519722
JAK2 ; INSL6
C 0.700 CausalMutation CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920

2012
dbSNP: rs1057519722
rs1057519722
JAK2 ; INSL6
C 0.700 CausalMutation CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270

2012
dbSNP: rs1057519723
rs1057519723
JAK2 ; INSL6
T 0.700 CausalMutation CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270

2012
dbSNP: rs1057519723
rs1057519723
JAK2 ; INSL6
C 0.700 CausalMutation CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270

2012
dbSNP: rs1057519723
rs1057519723
JAK2 ; INSL6
T 0.700 CausalMutation CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920

2012
dbSNP: rs1057519723
rs1057519723
JAK2 ; INSL6
C 0.700 CausalMutation CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920

2012
dbSNP: rs1057519743
rs1057519743
CRLF2
C 0.700 CausalMutation CLINVAR Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study. 22368272

2012
dbSNP: rs1057519759
rs1057519759
IL7R
T 0.700 GeneticVariation CLINVAR Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. 22897847

2012
dbSNP: rs1057519759
rs1057519759
IL7R
T 0.700 GeneticVariation CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920

2012
dbSNP: rs151047872
rs151047872
JAK1
A 0.700 GeneticVariation CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920

2012
dbSNP: rs1057519753
rs1057519753
JAK1
A 0.700 GeneticVariation CLINVAR Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. 21680795

2011
dbSNP: rs1057519743
rs1057519743
CRLF2
C 0.700 CausalMutation CLINVAR Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia. 19907440

2010
dbSNP: rs1057519743
rs1057519743
CRLF2
C 0.700 CausalMutation CLINVAR Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. 20018760

2010
dbSNP: rs1057519743
rs1057519743
CRLF2
C 0.700 CausalMutation CLINVAR Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. 19965641

2010
dbSNP: rs869312953
rs869312953
JAK1
T 0.700 GeneticVariation CLINVAR ALL-associated JAK1 mutations confer hypersensitivity to the antiproliferative effect of type I interferon. 20167706

2010
dbSNP: rs1057519721
rs1057519721
JAK2 ; INSL6
G 0.700 CausalMutation CLINVAR JAK mutations in high-risk childhood acute lymphoblastic leukemia. 19470474

2009
dbSNP: rs1057519722
rs1057519722
JAK2 ; INSL6
C 0.700 CausalMutation CLINVAR JAK mutations in high-risk childhood acute lymphoblastic leukemia. 19470474

2009
dbSNP: rs1057519723
rs1057519723
JAK2 ; INSL6
T 0.700 CausalMutation CLINVAR JAK mutations in high-risk childhood acute lymphoblastic leukemia. 19470474

2009