|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease.
|
19434512 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.
|
22417945 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a common polymorphism in exon 7 of the eNOS gene (894G-->T) has been reported to be a strong risk factor for coronary artery disease.
|
9731617 |
1998 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was conducted to investigate the possible outcome of interaction between endothelial nitric oxide (NOS3) G894T and cholesteryl ester transfer TaqIB variants on the risk of coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM).
|
23157875 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G894T polymorphism of the eNOS gene is associated with the presence of CAD, and in conjunction with hyperhomocysteinemia, increased the risk of CAD severity in a Tunisian population.
|
16284093 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, although Glu298Asp did not show association with CAD and lipid profile in the studied cohort, it may exert its effect through blood pressure; however, the mechanism of this effect needs to be explored in the future.
|
28620990 |
2017 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07).
|
17108813 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Glu298-->Asp polymorphism of the eNOS gene appears to be associated with the presence, extent, and severity of angiographically assessed coronary artery disease.
|
12010932 |
2002 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this issue of Clinical Science, Agema and co-workers report the results of a genetic association study of eNOS (endothelial nitric oxide synthase) gene polymorphisms (-786T --> C, intron 4b --> a and Glu298 --> Asp) in patients with angiographic CAD (coronary artery disease), and/or prior MI (myocardial infarction) and a group of healthy population-based controls.
|
15283697 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant associations were found between -1562 C/T (p = 0.557), Glu298Asp (p = 0.432), and -786 T/C (p = 0.055) polymorphisms and CAD.
|
19435423 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present case-control study, we found no evidence of an association between the Glu298Asp variant of the eNOS gene and CAD/MI among Taiwanese.
|
11802531 |
2001 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the G894T (rs1799983) polymorphism of the eNOS gene was associated with CAD in Tunisian patients.
|
25748584 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the G894T polymorphism of the eNOS gene was not associated with CAD in Chilean individuals.
|
16616056 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease.
|
11579346 |
2001 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings show that the 27-bp VNTR polymorphic locus, but not the c.894G>T polymorphic locus, is associated with CAD and that it may regulate NOS3 pre-mRNA splicing in a length-dependent manner.
|
30447355 |
2019 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AMI.
|
18495009 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Glu298Asp, T786-C and 27 bp VNTR b/a) with CAD.
|
25409023 |
2014 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the eNOS Glu-298-->Asp mutation is common, occurring with an allele frequency of 32.5%, but is not associated with either the occurrence or severity of CAD in the Australian population or with other established coronary risk factors assessed in our study.
|
10475066 |
1999 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease.
|
14989558 |
2003 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype and allele distributions of G894T and intron 4a/b polymorphisms were not significantly different between T2DM subjects with and without CAD/MI.
|
23182401 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients.
|
27613099 |
2016 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the 894G>T, -786T>C and 4a/4b polymorphisms of the NOS3 were not associated with CAD in the studied subjects.
|
19931521 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present data extends earlier observations by the findings that predominantly younger T allele carriers of the ecNOS Glu(298)Asp gene polymorphism with various coronary high-risk profiles had an increased risk to suffer CAD and/or MI.
|
11755935 |
2002 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the effects of a variable nucleotide tandem repeats (VNTR) in intron 4, G894T in exon 7 and T-786C at the promoter region of NOS3 on i) C-reactive protein (CRP) and macrophage-colony stimulating-factor (MCSF), and ii) augmentation index (AI) measured by pulse-wave analysis , flow-mediated dilation (FMD) of the brachial artery, intima-media thickness (IMT) of the carotid and femoral artery using ultrasonography and ankle-brachial index (ABI) in 122 patients with chronic coronary artery disease (CAD) who underwent coronary angiography.
|
17003932 |
2006 |