|
rs1469698992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
|
8493294 |
1993 |
|
rs6280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
|
8493294 |
1993 |
|
rs6318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have examined a structural variant of the 5-HT2C receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls.
|
8823764 |
1996 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
|
rs147837176
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It therefore remains possible that Glu602Gly may be a rare cause of bipolar affective disorder.
|
10889530 |
2000 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi(2)=6.766, d.f.=1, P=0.009).
|
11027844 |
2000 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi(2)=6.766, d.f.=1, P=0.009).
|
11027844 |
2000 |
|
rs169068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the British population we found association to B</span>PAD with missense mutation Leu48Met (P = 0.003) and missense mutation Pro335Leu (P = 0.004).
|
12192619 |
2002 |
|
rs34608001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Danish population, association was suggested between silent SNP G573A and BPAD (P = 0.008).
|
12192619 |
2002 |
|
rs4988483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the British population we found association to BPAD with missense mutation Leu48Met</span> (P = 0.003) and missense mutation Pro335Leu (P = 0.004).
|
12192619 |
2002 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs2076137
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association was observed for rs2235349 and rs2076137 with SCZ and ss16339163 with BPAD in case-control study.
|
15992519 |
2005 |
|
rs2235349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association was observed for rs2235349 and rs2076137 with SCZ and ss16339163 with BPAD in case-control study.
|
15992519 |
2005 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
|
rs3788266
|
|
|
0.020 |
GeneticVariation |
BEFREE |
S100B single nucleotide polymorphisms (SNPs) rs2839350 (P = 0.022) and rs3788266 (P = 0.031) were significantly associated with BPAD.
|
17525977 |
2007 |
|
rs2839350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
S100B single nucleotide polymorphisms (SNPs) rs2839350 (P = 0.022) and rs3788266 (P = 0.031) were significantly associated with BPAD.
|
17525977 |
2007 |
|
rs17110563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD.
|
17905754 |
2008 |
|
rs1386482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006).
|
19352219 |
2009 |
|
rs1386483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD.
|
19352219 |
2009 |
|
rs1386486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006).
|
19352219 |
2009 |
|
rs4290270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD.
|
19352219 |
2009 |
|
rs9834970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35).
|
20414141 |
2010 |
|
rs3788266
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001).
|
21714070 |
2011 |
|
rs707284
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs707284 and rs839523) showed nominal significance in the BPAD patients but this was eliminated after permutation.
|
21993442 |
2012 |