|
rs2839350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
S100B single nucleotide polymorphisms (SNPs) rs2839350 (P = 0.022) and rs3788266 (P = 0.031) were significantly associated with BPAD.
|
17525977 |
2007 |
|
rs9834970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35).
|
20414141 |
2010 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi(2)=6.766, d.f.=1, P=0.009).
|
11027844 |
2000 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi(2)=6.766, d.f.=1, P=0.009).
|
11027844 |
2000 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
|
rs2812393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two-locus analysis showed C-C (rs766288-rs2812393) as a risk combination in BPAD, and G-T (rs2812393-rs821616) as a protective combination in SCZ and combined cases of BPAD or SCZ.
|
22673686 |
2012 |
|
rs821616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two-locus analysis showed C-C (rs766288-rs2812393) as a risk combination in BPAD, and G-T (rs2812393-rs821616) as a protective combination in SCZ and combined cases of BPAD or SCZ.
|
22673686 |
2012 |
|
rs6280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
|
8493294 |
1993 |
|
rs707284
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs707284 and rs839523) showed nominal significance in the BPAD patients but this was eliminated after permutation.
|
21993442 |
2012 |
|
rs839523
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs707284 and rs839523) showed nominal significance in the BPAD patients but this was eliminated after permutation.
|
21993442 |
2012 |
|
rs6318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have examined a structural variant of the 5-HT2C receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls.
|
8823764 |
1996 |
|
rs1062613
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot studies, and all of them are of functional relevance.
|
22832903 |
2012 |
|
rs1176744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot studies, and all of them are of functional relevance.
|
22832903 |
2012 |
|
rs3831455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot studies, and all of them are of functional relevance.
|
22832903 |
2012 |
|
rs166508
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One single SNP (rs166508) was associated with the BPAD phenotype (P = 0.0187).
|
23280964 |
2013 |
|
rs2076137
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association was observed for rs2235349 and rs2076137 with SCZ and ss16339163 with BPAD in case-control study.
|
15992519 |
2005 |
|
rs2235349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association was observed for rs2235349 and rs2076137 with SCZ and ss16339163 with BPAD in case-control study.
|
15992519 |
2005 |
|
rs1469698992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
|
8493294 |
1993 |
|
rs2251219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is strong evidence of association of rs2251219 with BP.
|
22560537 |
2012 |
|
rs3788266
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001).
|
21714070 |
2011 |
|
rs3788266
|
|
|
0.020 |
GeneticVariation |
BEFREE |
S100B single nucleotide polymorphisms (SNPs) rs2839350 (P = 0.022) and rs3788266 (P = 0.031) were significantly associated with BPAD.
|
17525977 |
2007 |
|
rs147837176
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It therefore remains possible that Glu602Gly may be a rare cause of bipolar affective disorder.
|
10889530 |
2000 |