|
rs1469698992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
|
8493294 |
1993 |
|
rs6280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
|
8493294 |
1993 |
|
rs6318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have examined a structural variant of the 5-HT2C receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls.
|
8823764 |
1996 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi(2)=6.766, d.f.=1, P=0.009).
|
11027844 |
2000 |
|
rs147837176
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It therefore remains possible that Glu602Gly may be a rare cause of bipolar affective disorder.
|
10889530 |
2000 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi(2)=6.766, d.f.=1, P=0.009).
|
11027844 |
2000 |
|
rs169068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the British population we found association to B</span>PAD with missense mutation Leu48Met (P = 0.003) and missense mutation Pro335Leu (P = 0.004).
|
12192619 |
2002 |
|
rs34608001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Danish population, association was suggested between silent SNP G573A and BPAD (P = 0.008).
|
12192619 |
2002 |
|
rs4988483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the British population we found association to BPAD with missense mutation Leu48Met</span> (P = 0.003) and missense mutation Pro335Leu (P = 0.004).
|
12192619 |
2002 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
|
rs2076137
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association was observed for rs2235349 and rs2076137 with SCZ and ss16339163 with BPAD in case-control study.
|
15992519 |
2005 |
|
rs2235349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association was observed for rs2235349 and rs2076137 with SCZ and ss16339163 with BPAD in case-control study.
|
15992519 |
2005 |
|
rs3788266
|
|
|
0.020 |
GeneticVariation |
BEFREE |
S100B single nucleotide polymorphisms (SNPs) rs2839350 (P = 0.022) and rs3788266 (P = 0.031) were significantly associated with BPAD.
|
17525977 |
2007 |
|
rs2839350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
S100B single nucleotide polymorphisms (SNPs) rs2839350 (P = 0.022) and rs3788266 (P = 0.031) were significantly associated with BPAD.
|
17525977 |
2007 |
|
rs17110563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD.
|
17905754 |
2008 |
|
rs1386482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006).
|
19352219 |
2009 |
|
rs1386483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD.
|
19352219 |
2009 |
|
rs1386486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006).
|
19352219 |
2009 |
|
rs4290270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD.
|
19352219 |
2009 |
|
rs9834970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35).
|
20414141 |
2010 |
|
rs3788266
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001).
|
21714070 |
2011 |
|
rs1062613
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot studies, and all of them are of functional relevance.
|
22832903 |
2012 |