|
rs1010553
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six obesity-associated SNPs significantly departed from additive to dominant (N = 5) or recessive (N = 1) models, and a significant interaction was found between rs274609 (TNNI3K) and rs1010553 (ITIH4) on childhood obesity risk.
|
29769702 |
2019 |
|
rs1996023
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the novel SNP rs1996023 is located at protein coding gene GNPDA2 (ccFDR = 1.28E-02), which has been reported to influence the risk of T2D and CO through central nervous system.
|
30816286 |
2019 |
|
rs274609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six obesity-associated SNPs significantly departed from additive to dominant (N = 5) or recessive (N = 1) models, and a significant interaction was found between rs274609 (TNNI3K) and rs1010553 (ITIH4) on childhood obesity risk.
|
29769702 |
2019 |
|
rs2943650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that IRS1 rs2943650 was significantly associated with BMI and risk of childhood obesity.
|
31248719 |
2019 |
|
rs8057044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Distribution of FTO single nutleotide polymorphisms (SNPs) rs1421085T>C, rs9939609T>A, rs8057044G>A and copy number variation (CNV) was evaluated in association with childhood obesity or overweight status in children with Mayan ethnicity.
|
30537186 |
2019 |
|
rs1256046734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study evaluates the relationship between leptin G2548A (rs7799039) and leptin receptors (Gln223Arg (rs1137101) genotyping and its leptin level and the risk of childhood obesity.
|
29412799 |
2018 |
|
rs641738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We first demonstrated in childhood obesity the role of the MBOAT7 rs641738 variant on serum ALT and the combined effect of the MBOAT7, PNPLA3, and TM6SF2 variants on NAFLD risk.
|
29601441 |
2018 |
|
rs7799039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study evaluates the relationship between leptin G2548A (rs7799039) and leptin receptors (Gln223Arg (rs1137101) genotyping and its leptin level and the risk of childhood obesity.
|
29412799 |
2018 |
|
rs12500837
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From a large European multi-center study on childhood obesity, 4,528 children (2.0-9.9 years, mean age 6.0±1.8 SD; boys 52.2%) were randomly selected, stratifying by age, sex and country, and genotyped for tag single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653,C:T) of NMU gene, then haplotypes were inferred.
|
28235053 |
2017 |
|
rs1558902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple comparisons, six of these SNPs were robustly associated with childhood obesity: <i>FTO</i>-rs1558902 (<i>P</i>=5.6×10<sup>-5</sup>), <i>MC4R</i>-rs2331841 (<i>P</i>=4.4×10<sup>-4</sup>), <i>GNPDA2</i>-rs16858082 (<i>P</i> = 3.4×10<sup>-4</sup>), <i>PCSK1</i>-rs261967 (<i>P</i> = 0.001), <i>SEC16B</i>-rs516636 (<i>P</i> = 0.004) and <i>MAP2K5</i>-rs4776970 (<i>P</i> = 0.004), with odds ratios ranging from 1.211 to 1.421; while <i>ITIH4</i>-rs2535633 and <i>BDNF</i>-rs2030323 yielded nominal association with the same trait (<i>P</i> < 0.05).
|
29212175 |
2017 |
|
rs2030323
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple comparisons, six of these SNPs were robustly associated with childhood obesity: <i>FTO</i>-rs1558902 (<i>P</i>=5.6×10<sup>-5</sup>), <i>MC4R</i>-rs2331841 (<i>P</i>=4.4×10<sup>-4</sup>), <i>GNPDA2</i>-rs16858082 (<i>P</i> = 3.4×10<sup>-4</sup>), <i>PCSK1</i>-rs261967 (<i>P</i> = 0.001), <i>SEC16B</i>-rs516636 (<i>P</i> = 0.004) and <i>MAP2K5</i>-rs4776970 (<i>P</i> = 0.004), with odds ratios ranging from 1.211 to 1.421; while <i>ITIH4</i>-rs2535633 and <i>BDNF</i>-rs2030323 yielded nominal association with the same trait (<i>P</i> < 0.05).
|
29212175 |
2017 |
|
rs2535633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple comparisons, six of these SNPs were robustly associated with childhood obesity: <i>FTO</i>-rs1558902 (<i>P</i>=5.6×10<sup>-5</sup>), <i>MC4R</i>-rs2331841 (<i>P</i>=4.4×10<sup>-4</sup>), <i>GNPDA2</i>-rs16858082 (<i>P</i> = 3.4×10<sup>-4</sup>), <i>PCSK1</i>-rs261967 (<i>P</i> = 0.001), <i>SEC16B</i>-rs516636 (<i>P</i> = 0.004) and <i>MAP2K5</i>-rs4776970 (<i>P</i> = 0.004), with odds ratios ranging from 1.211 to 1.421; while <i>ITIH4</i>-rs2535633 and <i>BDNF</i>-rs2030323 yielded nominal association with the same trait (<i>P</i> < 0.05).
|
29212175 |
2017 |
|
rs6234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to confirming rs6232 and rs6234 in <i>PCSK1</i> as polygenic risk variants for childhood obesity, we describe an association of rs725522 with insulin metabolism.
|
28271036 |
2017 |
|
rs6827359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From a large European multi-center study on childhood obesity, 4,528 children (2.0-9.9 years, mean age 6.0±1.8 SD; boys 52.2%) were randomly selected, stratifying by age, sex and country, and genotyped for tag single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653,C:T) of NMU gene, then haplotypes were inferred.
|
28235053 |
2017 |
|
rs9999653
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From a large European multi-center study on childhood obesity, 4,528 children (2.0-9.9 years, mean age 6.0±1.8 SD; boys 52.2%) were randomly selected, stratifying by age, sex and country, and genotyped for tag single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653,C:T) of NMU gene, then haplotypes were inferred.
|
28235053 |
2017 |
|
rs1416580204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effects of Advanced Glycation End Products (RAGE)-374T/A and Gly82Ser variants and soluble-RAGE levels to obesity in children.
|
27188863 |
2016 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effects of Advanced Glycation End Products (RAGE)-374T/A and Gly82Ser variants and soluble-RAGE levels to obesity in children.
|
27188863 |
2016 |
|
rs3746619
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed high population differentiation between European and African populations at two MC3R childhood obesity- and insulin resistance-associated single-nucleotide polymorphisms (rs3746619 and rs3827103) using Wright's F statistics.
|
26909893 |
2016 |
|
rs3827103
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed high population differentiation between European and African populations at two MC3R childhood obesity- and insulin resistance-associated single-nucleotide polymorphisms (rs3746619 and rs3827103) using Wright's F statistics.
|
26909893 |
2016 |
|
rs1319501
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the effects of traditional metabolic risk factors (MRFs) and NAMPT polymorphisms T/C (rs1319501) and A/G (rs3801266) or haplotypes on visfatin/NAMPT levels in obese children and adolescents, and whether NAMPT polymorphisms and/or haplotypes are associated with susceptibility to childhood obesity.
|
24100423 |
2015 |
|
rs2273773
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children.
|
25233986 |
2015 |
|
rs2501432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Cannabinoid Receptor 2 Q63R Variant Modulates the Relationship between Childhood Obesity and Age at Menarche.
|
26447698 |
2015 |
|
rs35761398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Cannabinoid Receptor 2 Q63R Variant Modulates the Relationship between Childhood Obesity and Age at Menarche.
|
26447698 |
2015 |
|
rs3801266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the effects of traditional metabolic risk factors (MRFs) and NAMPT polymorphisms T/C (rs1319501) and A/G (rs3801266) or haplotypes on visfatin/NAMPT levels in obese children and adolescents, and whether NAMPT polymorphisms and/or haplotypes are associated with susceptibility to childhood obesity.
|
24100423 |
2015 |
|
rs3918188
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |