|
rs10475878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An additional 12 SNPs were associated with the PD phenotype at P ≤ 0.05 (APOE: rs405509, rs439401; TOMM40: rs8106922, and KIBRA: rs4320284, rs11740112, rs10040267, rs13171394, rs6555802, rs2241368, rs244904, rs6555805, and rs10475878).
|
30706571 |
2019 |
|
rs405509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An additional 12 SNPs were associated with the PD phenotype at P ≤ 0.05 (APOE: rs405509, rs439401; TOMM40: rs8106922, and KIBRA: rs4320284, rs11740112, rs10040267, rs13171394, rs6555802, rs2241368, rs244904, rs6555805, and rs10475878).
|
30706571 |
2019 |
|
rs1272596579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The c.46G>T [p. Gly16Trp] variant in exon 1 was identified in a male PD patient, while a heterozygous frameshift variant, c.429delT [p. Val143ValfsX4], in exon 5 was found in an HC.
|
28455698 |
2018 |
|
rs1450426641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A GBA p.Trp378Gly mutation was identified in two RBD and four PD patients (1% of all patients combined), and not in controls.
|
29920646 |
2018 |
|
rs2276109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2276109 and rs652438 allele and genotype frequencies were not associated with dementia in PD patients.
|
28655442 |
2018 |
|
rs652438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2276109 and rs652438 allele and genotype frequencies were not associated with dementia in PD patients.
|
28655442 |
2018 |
|
rs80356718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The p.N267S heterozygous mutation was detected in one sporadic PD patient.
|
29801890 |
2018 |
|
rs11564148
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 64-year old male Parkinson's disease (PD) patient with S1647T variant in the LRRK2 gene.
|
28395805 |
2017 |
|
rs33949390
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 59-year old male Parkinson's disease (PD) patient with R1628P variant in the LRRK2 gene.
|
28395802 |
2017 |
|
rs3851179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
More genetic studies using large-sized and well-defined matched samples of AD and PD patients from mixed populations as well as functional correlation analysis are urgently needed to clarify the role of rs3851179 in the AD/PD risk.
|
28567584 |
2017 |
|
rs7133914
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 72-year old female Parkinson's disease (PD) patient with R1398H variant in the LRRK2 gene.
|
28395803 |
2017 |
|
rs7308720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 64-year old male Parkinson's disease (PD) patient with N551K variant in the LRRK2 gene.
|
28395804 |
2017 |
|
rs894278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusions:</b> Hyposmia was associated with RBD in PD patients with the minor G allele of rs894278, which represent one specific subtype of PD.
|
28979204 |
2017 |
|
rs1130214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of AKT1 have been shown to influence brain function of Parkinson's disease (PD) patients, and in this paper our aim is to investigate the association between the three single-nucleotide polymorphisms (rs2498799; rs2494732; rs1130214) and PD in Han Chinese.
|
27353512 |
2016 |
|
rs2230288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The discovery that E326K</span> negatively impacts cognitive performance approximately doubles the proportion of PD patients we now recognize are at risk for more severe GBA-related cognitive deficits.
|
26296077 |
2016 |
|
rs2242446
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is a pilot study assessing the impact of polymorphisms of serotonin transporter (5-HTT; 5-HTTLPR (S/L)) and norepinephrine transporter (NET; rs2242446 (T/C)) genes on selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) response in Korean panic disorder (PD) patients.
|
26508020 |
2016 |
|
rs2494732
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of AKT1 have been shown to influence brain function of Parkinson's disease (PD) patients, and in this paper our aim is to investigate the association between the three single-nucleotide polymorphisms (rs2498799; rs2494732; rs1130214) and PD in Han Chinese.
|
27353512 |
2016 |
|
rs2498799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of AKT1 have been shown to influence brain function of Parkinson's disease (PD) patients, and in this paper our aim is to investigate the association between the three single-nucleotide polymorphisms (rs2498799; rs2494732; rs1130214) and PD in Han Chinese.
|
27353512 |
2016 |
|
rs34778348
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we performed genotyping for the LRRK2 G2385R variant in PD patients recruited from the Movement Disorder Clinic of Xuanwu Hospital in Beijing and in healthy controls randomly selected from the Beijing Longitudinal Study on Aging cohort.
|
27699718 |
2016 |
|
rs6280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DRD3 p.Ser9Gly (rs6280) CT genotype is associated with ICD in Indian PD patients and this association is novel.
|
27325396 |
2016 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aims to explore whether Parkinson's disease (PD) patients with reduced ALDH2 activity owing to the rs671 polymorphism are at risk for neuropsychological impairments.
|
27453488 |
2016 |
|
rs72470545
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We previously identified the G399S HtrA2 mutation in Parkinson's disease (PD) patients and reported mitochondrial dysfunction in vitro.
|
26604148 |
2016 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, TLR4 (Thr399Ile) polymorphism showed significant association with PD patients having two or more episodes of peritonitis compared to patients with no peritonitis.
|
26490558 |
2015 |
|
rs62063857
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After the stratification analysis according to gender, both male and female PD patients showed association with the alleles and genotypes of the rs62063857 polymorphism of the saitohin gene (χ2 = 9.476, P = 0.009; χ2 = 7.593, P = 0.022, respectively).
|
25168738 |
2015 |
|
rs1375532403
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this study was to characterize the correlation between the Val158Met polymorphism in the COMT gene and the motor complication "wearing-off" in Chinese PD patients.
|
25108642 |
2014 |