|
rs35068177
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs C1236T, G1199T/A, and A1308G were determined using Pyrosequencing in 51 patients with advanced ovarian cancer and correlated to the progression free survival.
|
17828752 |
2008 |
|
rs533117495
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms such as ERCC1 8092C>A, ABCB1 2677G>T/A, GSTP1 I105V and GSTT1 polymorphisms may affect drug response, toxicity and survival in patient with EOC who received taxane- and platinum-based chemotherapy after surgery.
|
19203783 |
2009 |
|
rs1127313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Expression quantitative trait locus analysis in EOC tissue revealed significant associations (P<0.05) with ADAR expression for several SNPs in ADAR, including rs1127313 (G/A), a SNP in the 3' untranslated region.
|
27911851 |
2016 |
|
rs186724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Firstly, individuals carried ERBB4 rs186724 GG genotype had poorer overall survival compared with those carried CC/CT genotypes in ovarian cancer, while the participants with rs1836724 GA genotype had the same overall survival with that in participants with rs1836724 AA genotype in accordance with the result of Cox regression and Kaplan-Meier analyses.
|
29125883 |
2018 |
|
rs1955513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other variants of interest included another in ARHGEF10L, rs10788679, which was associated with invasive serous EOC risk (OR = 1.07, p = 0.00026) and two variants in AKAP6 (A-kinase anchoring protein 6) which were associated with risk of invasive EOC (rs1955513, OR = 0.90, p = 0.00033; rs927062, OR = 0.94, p = 0.00059).
|
29979793 |
2018 |
|
rs927062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other variants of interest included another in ARHGEF10L, rs10788679, which was associated with invasive serous EOC risk (OR = 1.07, p = 0.00026) and two variants in AKAP6 (A-kinase anchoring protein 6) which were associated with risk of invasive EOC (rs1955513, OR = 0.90, p = 0.00033; rs927062, OR = 0.94, p = 0.00059).
|
29979793 |
2018 |
|
rs4525119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype.
|
29247577 |
2018 |
|
rs2363956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To determine whether the excess of colon cancer in some breast-ovarian cancer families is related to the I1307K mutation, we evaluated 264 Ashkenazi Jews from 158 families.
|
9407954 |
1997 |
|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
|
rs1801155
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
|
rs1801155
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To determine whether the excess of colon cancer in some breast-ovarian cancer families is related to the I1307K mutation, we evaluated 264 Ashkenazi Jews from 158 families.
|
9407954 |
1997 |
|
rs11954856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study demonstrated significantly increased APC rs11954856 and rs351771 SNP frequencies in Polish women with ovarian cancer.
|
24078348 |
2014 |
|
rs351771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study demonstrated significantly increased APC rs11954856 and rs351771 SNP frequencies in Polish women with ovarian cancer.
|
24078348 |
2014 |
|
rs459552
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied nine single nucleotide polymorphisms (SNPs) located in CTNNB1 (β-catenin) [rs4533622, rs2953], APC (rs11954856, rs351771, rs459552), and AXIN2 (rs4074947, rs7224837, rs3923087, rs2240308) in women with ovarian cancer without BRCA1/BRCA2 mutations (n = 228) and controls (n = 282).
|
24078348 |
2014 |
|
rs1130409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1130409 polymorphism was significantly associated with a risk for ovarian cancer.
|
24257553 |
2013 |
|
rs1760944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the rs1760944 polymorphism was not found to be associated with a risk for ovarian cancer.
|
24257553 |
2013 |
|
rs10788679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other variants of interest included another in ARHGEF10L, rs10788679, which was associated with invasive serous EOC risk (OR = 1.07, p = 0.00026) and two variants in AKAP6 (A-kinase anchoring protein 6) which were associated with risk of invasive EOC (rs1955513, OR = 0.90, p = 0.00033; rs927062, OR = 0.94, p = 0.00059).
|
29979793 |
2018 |
|
rs2256787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One variant, ARHGEF10L (Rho guanine nucleotide exchange factor 10 like) rs2256787, was associated with increased endometrioid EOC risk (OR = 1.33, p = 4.46 x 10-6).
|
29979793 |
2018 |
|
rs34301344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ARLTS1 mutation Trp149Stop and Cys148Arg have been shown to be associated with familial cancers, but limited information is available regarding the impact of ARLTS1 variants on familial ovarian cancer (OC).
|
19509554 |
2009 |
|
rs3803185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ARLTS1 Cys148Arg revealed a significant association with an increased risk of familial OC compared with both sporadic cases and controls in a dose-dependent manner (P = 0.0031 and 0.012, respectively).
|
19509554 |
2009 |
|
rs755100942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ARLTS1 mutation Trp149Stop and Cys148Arg have been shown to be associated with familial cancers, but limited information is available regarding the impact of ARLTS1 variants on familial ovarian cancer (OC).
|
19509554 |
2009 |
|
rs74315464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008).
|
25591549 |
2015 |
|
rs751039340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008).
|
25591549 |
2015 |