|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study indicated that XRCC1 Arg194Trp, Arg280His, and Arg399Gln did not affect OS after platinum-based chemotherapy in OC patients.
|
30407287 |
2018 |
|
rs28897672
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We identified a founder mutation (4153delA, 5382insC or C61G) in 6% of 235 unselected cases of breast cancer and in 19% of 43 unselected cases of ovarian cancer.
|
20345474 |
2010 |
|
rs28897672
|
|
|
0.030 |
GeneticVariation |
BEFREE |
While the Cys61Gly mutation appeared underrepresented in ovarian cancer as compared with breast cancer cases from the same population (p = 0.01), the 4153delA mutation made a higher contribution to ovarian cancer than to breast cancer (p < 0.01).
|
20569256 |
2010 |
|
rs28897672
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The risk for breast cancer was 42% higher among first degree relatives of carriers of the C61G missense mutation compared to other mutations (HR = 1.42; p = 0.10) and the risk for ovarian cancer was lower than average (OR = 0.26; p = 0.03).
|
16227521 |
2006 |
|
rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that the COMT rs4680 polymorphism may not contribute to the risk of ovarian cancer.
|
25292091 |
2014 |
|
rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Lack of associations of the COMT Val158Met polymorphism with risk of endometrial and ovarian cancer: a pooled analysis of case-control studies.
|
25124595 |
2014 |
|
rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Meta-analysis showed that the rs4680 polymorphism was not associated with ovarian cancer [GG vs (GA+AA): OR = 1.02, 95%CI = 0.88-1.19; G vs A allele: OR = 1.0, 95%CI = 0.90-1.11].
|
26681027 |
2015 |
|
rs5918
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.
|
19876733 |
2010 |
|
rs5918
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.
|
17220212 |
2007 |
|
rs5918
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer.
|
16322334 |
2005 |
|
rs61764370
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this study, we investigated a hypothesized association between an increased risk of OC and a variant allele of KRAS at rs61764370, referred to as the KRAS-variant, which disrupts a let-7 miRNA binding site in this oncogene.
|
20647319 |
2010 |
|
rs61764370
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently, a variant allele in the 3'UTR of the KRAS gene (rs61764370 T>G) was shown to be associated with an increased risk for developing non-small cell lung cancer, as well as ovarian cancer, and was most enriched in ovarian cancer patients from hereditary breast and ovarian cancer families.
|
20676756 |
2011 |
|
rs61764370
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These data exclude the possibility of an association between rs61764370 and a clinically significant risk of ovarian cancer or of familial ovarian cancer.
|
21385923 |
2011 |
|
rs80357796
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rare form of the Q356R polymorphism was significantly ( P = 0.03) associated with a family history of ovarian cancer, suggesting that this polymorphism may influence ovarian cancer risk.
|
10196379 |
1999 |
|
rs80357796
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No association was detected between EOC risk and BRCA1 Q356R, BRCA1 P871L, RAD51 g135c, RAD51 g172t, RAD52 c2259t, NBS1 L34L, NBS1 E185Q, NBS1 A399A, NBS1 P672P, XRCC2 g4324c, XRCC2 c41657t and XRCC3 T241M.
|
15924337 |
2005 |
|
rs80357796
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We resequenced BRCA1 and BRCA2 in 194 women with a familial history of breast and/or ovarian cancer and identified nine possibly biologically relevant polymorphisms (BRCA1 Gln356Arg, Pro871Leu, Glu1038Gly, Ser1613Gly, and Met1652Ile.
|
19661094 |
2009 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No statistically significant associations between XRCC3 rs861539 polymorphisms and ovarian cancer risk were observed in any genetic models.
|
25006581 |
2014 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The obtained results indicate that XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women.
|
26801223 |
2016 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the subgroup analysis according to ethnicity, the results suggested that XRCC3 Thr241Met polymorphism was not associated with the risk of ovarian cancer in Caucasians population.
|
24254304 |
2014 |
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the present study we investigate the relevance of RAD51 -135C > G, TP53 R72P, NQO1*2 and CASP8 D302H polymorphisms as potential modifiers of BC and/or OC susceptibility conferred by these mutations.
|
19214744 |
2010 |
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The minor allele of CASP8 D302H was significantly associated with a reduced risk of breast cancer (per-allele HR, 0.85; 95% CI, 0.76-0.97; P(trend) = 0.011) and ovarian cancer (per-allele HR, 0.69; 95% CI, 0.53-0.89; P(trend) = 0.004) for BRCA1 but not for BRCA2 mutation carriers.
|
20978178 |
2010 |
|
rs1048943
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Ile462Val status seems to represent a meaningful risk factor for ovarian cancer in Caucasians.
|
22733497 |
2012 |
|
rs1048943
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CYP1A1 Ile462Val is a risk factor for ovarian cancer development.
|
22277800 |
2012 |
|
rs1051740
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Overall results demonstrated that the association between <i>EPHX1</i> polymorphism rs1051740</span> and ovar</span>ian cancer risk had no statistical significance either in total analysis or in subgroup analyses by ethnicity and source of control.
|
31174441 |
2019 |
|
rs1051740
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The microsomal epoxide hydrolase Tyr113His polymorphism: association with risk of ovarian cancer.
|
11255266 |
2001 |