|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
This study demonstrates a novel tumor suppressor role for miR-876 in CCA, identifies BCL-XL as an actionable target, and suggests a potential therapeutic role for miR-876 in CCA.
|
31409772 |
2019 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In vivo studies revealed that miR-876-5p overexpression inhibited tumour growth of OS in mice.
|
30773847 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
We also demonstrated the inhibitory effect of miR-876-3p on tumor growth in glioma using an in vivo model.
|
31497212 |
2019 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The tumour suppressive roles of miR‑876‑5p overexpression in GBM cells were significantly reversed by FOXM1 reintroduction.
|
30365126 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
miR-876-5p, which functions as a tumor suppressor in HNSCC, inhibits metastasis by targeting vimentin and provides a novel therapeutic target for HNSCC treatment.
|
30181714 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Over-expression of ciRS-7 resulted in the reduced tumor-repressive function of miR-876-5p on its downstream target MAGE-A family.
|
29635069 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
MicroRNA-876-3p functions as a tumor suppressor gene and correlates with cell metastasis in pancreatic adenocarcinoma via targeting JAG2.
|
29736309 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
A xenograft tumour mouse model was established to address the roles of microRNA-876-5p and BMP-4 in lung cancer EMT <i>in vivo</i>.
|
29229885 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Decreased miR-876 expression notably correlated with lymphatic invasion metastasis, TNM stage and differentiation grade.
|
31239777 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
In addition, gain- and loss-of-function experiments demonstrated that miR-876-5p restoration suppressed whereas miR-876-5p knockdown promoted cell proliferation, migration and invasion in both U2OS and MG63 cells.
|
30773847 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Restoration of miR-876 expression decreased breast cancer cell proliferation, migration and invasion in vitro and restricted tumor growth in vivo as well as increased cell apoptosis.
|
31239777 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of miR-876-3p suppressed glioma cell proliferation, epithelial-mesenchymal transition, migration, and invasion.
|
31497212 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of miR‑876‑5p restricted the proliferation, induced the apoptosis and reduced the migration and invasion capabilities of GBM cells.
|
30365126 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
In summary, the results from the present study provide evidence that miR-876-5p suppresses breast cancer progression by regulating cell proliferation, migration and invasion in a TFAP2A-dependent manner.
|
31316633 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Quantitative RT-PCR was used to evaluate miR-876-5p levels in HNSCC cell lines and in 20 pairs of HNSCC with associated regional nodal metastases and HNSCC without metastatic primary tumors.
|
30181714 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Consequently, we found that miR-876-5p could inhibit both cell proliferation and metastasis.
|
29724530 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
MicroRNA-876-5p inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1.
|
29679906 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
MicroRNA-876-3p functions as a tumor suppressor gene and correlates with cell metastasis in pancreatic adenocarcinoma via targeting JAG2.
|
29736309 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
In animal experiments, enforced ciRS-7 increased ESCC tumor growth and metastasis through targeting miR-876-5p/MAGE-A family axis.
|
29635069 |
2018 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic expression of miR-876-5p suppressed cell migration and invasion in both HCCLM3 and MHCC97H cells.
|
29679906 |
2018 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Scratch and invasion assays were evaluated to determine the role of miR-876-5p in the regulation of HNSCC cell migration and invasion, respectively.
|
30181714 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
MicroRNA-876-5p expression significantly inhibited the migration, invasion and EMT of lung cancer cells <i>in vitro</i>, as well as metastasis <i>in vivo</i>, which required BMP-4 expression.
|
29229885 |
2017 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression.
|
31700026 |
2019 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Therefore, miRNAs with dysregulated expression are potential therapeutic targets for the treatment of GBM. miRNA‑876‑5p (miR‑876‑5p) has recently been identified to be aberrantly expressed and serve an important role in hepatocellular carcinoma and lung cancer.
|
30365126 |
2019 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
MicroRNAs (miRNAs) are widely expressed in human cells and closely associated with various types of cancer, including breast cancer. miR-876-5p has been indicated to participate in the tumorigenesis of certain types of cancer, such as hepatocellular carcinoma.
|
31316633 |
2019 |