|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
The results showed there was a significant difference in the incidence of lymph node metastasis (LNM) between high HOTTIP expression group and low HOTTIP expression group (OR=2.30, 95% CI: 1.58-3.35, P<0.0001).
|
28778381 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
The results showed that HOTTIP expression was significantly upregulated in the RCC tissues and cell lines, and it was closely associated with TNM stage, histological grade, lymph node metastasis and patient prognosis.
|
30511250 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
Biomarker
|
disease |
BEFREE |
In conclusion, this meta-analysis demonstrated that the higher expression level of HOTTIP is correlated with positive LNM and poor OS in different types of cancer and HOTTIP might serve as a novel predictor of LNM and survival in human cancer.
|
27806342 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
Biomarker
|
disease |
BEFREE |
Recently, three aberrant expressed oncogenic lncRNA (onco-lncRNAs), including HOXA transcript at the distal tip (HOTTIP), plasmacytoma variant translocation 1 (PVT1), and urothelial carcinoma associated 1 (UCA1) have been reported in LNM.
|
30993787 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Increased lncRNA HOTTIP expression levels were significantly associated with advanced FIGO stage and lymph node metastasis of ovarian cancer patients.
|
30452402 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
An increased HOTTIP expression in RCC was associated with a larger tumor size and a higher clinical stage, lymph node metastasis and vascular invasion.
|
30226576 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Our results found that HOTTIP was up-regulated in human primary PCa tissues with lymph node metastasis.
|
29884766 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the expression levels of HOTTIP and HOXA13 were both higher in gastric cancer which was poorly differentiated, at advanced TNM stages and exhibited lymph node-metastasis.
|
27108607 |
2016 |
|
Pancreatic carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
A long non-coding RNA named HOXA transcript at the distal tip (HOTTIP) has been reported to be significantly increased in several cancers, including hepatocellular cancer, pancreatic cancer and lung cancer.
|
28693275 |
2017 |
|
Pancreatic carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The current findings provided evidence that the functional rs1859168 A > C polymorphism may decrease the PC risk by down-regulating the HOTTIP expression.
|
28818070 |
2017 |
|
Pancreatic carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The prognostic value of HOTTIP and mGluR1 in pancreatic carcinoma was also examined.
|
29844833 |
2018 |
|
Pancreatic carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The expression patterns of HOTTIP splice variants in PC were also detected.
|
26447755 |
2015 |
|
Pancreatic carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
HOTTIP expression was higher in human pancreatic cancer tissue compared with in para-carcinoma tissue.
|
30008887 |
2018 |
|
Pancreatic carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
However, the role of HOTTIP in pancreatic cancer stem cells (PCSCs) remains unclear.
|
28947139 |
2017 |
|
Pancreatic carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration.
|
25912306 |
2015 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
A long non-coding RNA named HOXA transcript at the distal tip (HOTTIP) has been reported to be significantly increased in several cancers, including hepatocellular cancer, pancreatic cancer and lung cancer.
|
28693275 |
2017 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Consistent with this notion, a significant negative correlation between these miRNAs and HOTTIP exists in HCC tissue specimens.
|
26710269 |
2015 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
BACKGROUND The long noncoding RNA (lncRNA) HOTTIP is involved in gastric cancer tumorigenesis, papillary thyroid carcinoma, colorectal cancer, lung adenocarcinoma, and hepatocellular carcinoma, but it is unclear how HOTTIP exerts roles in nasopharyngeal carcinoma (NPC).
|
30685769 |
2019 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Furthermore, the meta‑analysis of 393 cases from multiple centers indicated that HOTTIP had high diagnostic value in HCC.
|
29039502 |
2017 |
|
Liver carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Among HOX genes, HOXA13 is most overexpressed in HCC and is known to be directly regulated by the long non-coding RNA HOTTIP.
|
29035381 |
2018 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Functionally, knock-down of HOTTIP attenuated HCC cell proliferation in vitro and markedly abrogated tumourigenicity in vivo.
|
25424744 |
2015 |
|
Liver carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Here, by correlating clinicopathological and expression data, we demonstrate that the levels of HOTTIP and HOXA13 are associated with HCC patients' clinical progression and predict disease outcome.
|
24114970 |
2014 |
|
Malignant neoplasm of pancreas
|
0.060 |
Biomarker
|
disease |
BEFREE |
However, the role of HOTTIP in pancreatic cancer stem cells (PCSCs) remains unclear.
|
28947139 |
2017 |
|
Malignant neoplasm of pancreas
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The current findings provided evidence that the functional rs1859168 A > C polymorphism may decrease the PC risk by down-regulating the HOTTIP expression.
|
28818070 |
2017 |
|
Malignant neoplasm of pancreas
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
HOTTIP expression was higher in human pancreatic cancer tissue compared with in para-carcinoma tissue.
|
30008887 |
2018 |