|
Pancreatic carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The current findings provided evidence that the functional rs1859168 A > C polymorphism may decrease the PC risk by down-regulating the HOTTIP expression.
|
28818070 |
2017 |
|
Pancreatic carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The expression patterns of HOTTIP splice variants in PC were also detected.
|
26447755 |
2015 |
|
Malignant neoplasm of pancreas
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The current findings provided evidence that the functional rs1859168 A > C polymorphism may decrease the PC risk by down-regulating the HOTTIP expression.
|
28818070 |
2017 |
|
Malignant neoplasm of pancreas
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The expression patterns of HOTTIP splice variants in PC were also detected.
|
26447755 |
2015 |
|
Malignant neoplasm of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We found that patients with HOTTIP rs5883064 C allele or rs1859168 A allele had increased lung cancer risk (P = 0.01, P = 0.01, respectively).
|
26729200 |
2016 |
|
Carcinoma of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We found that patients with HOTTIP rs5883064 C allele or rs1859168 A allele had increased lung cancer risk (P = 0.01, P = 0.01, respectively).
|
26729200 |
2016 |
|
Primary malignant neoplasm of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We found that patients with HOTTIP rs5883064 C allele or rs1859168 A allele had increased lung cancer risk (P = 0.01, P = 0.01, respectively).
|
26729200 |
2016 |
|
Osteoarthritis, Knee
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Heterogeneity tests proved that H19 rs2067051, MEG3 rs4378559 and HOTTIP rs202384's risk effects on KOA were more remarkable for female, BMI ≥ 25 and younger age (age < 60), respectively.
|
30086750 |
2018 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LncRNA HOTTIP is a vital oncogene in HCC, one of the deadliest cancers worldwide.
|
26710269 |
2015 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Pooled hazard ratios (HRs) and 95% confidence interval (CI) of HOTTIP for cancer survival were calculated.
|
28036281 |
2017 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Besides, increasing evidence has demonstrated that long non-coding RNA (lncRNA) HOTTIP played a crucial role in cancer pathogenesis.
|
29474928 |
2018 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently tumorigenic effects of one specific lncRNA, termed as 'HOXA transcript at the distal tip' (HOTTIP), on the initiation and progression of human cancer has been widely reported.
|
27546609 |
2016 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, this meta-analysis demonstrated that the higher expression level of HOTTIP is correlated with positive LNM and poor OS in different types of cancer and HOTTIP might serve as a novel predictor of LNM and survival in human cancer.
|
27806342 |
2017 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nevertheless, the potential function of HOTTIP in ovarian cancer (OC), a prevalent cancer among women worldwide, remains elusive.
|
31533774 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9.
|
28947139 |
2017 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
HIF-1α/HOTTIP/miR-101/ZEB1 axis plays essential role in hypoxia-induced EMT and metastasis of glioma, and HOTTIP may serve as a therapeutic target to reverse EMT and prevent glioma progression.
|
28886531 |
2017 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this study, we investigated the role of HOTTIP in ESCC and observed that HOTTIP/HOXA13 was upregulated in ESCC and promoted cell proliferation and metastasis in vivo and in vitro.
|
28534516 |
2017 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Upregulation of long noncoding RNA HOTTIP promotes metastasis of esophageal squamous cell carcinoma via induction of EMT.
|
27806322 |
2016 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that HOTTIP is required by the OTSCC cells to maintain their growth and metastasis in vitro.
|
30519045 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Moreover, HOTTIP silencing also suppressed tumor metastasis in nude mice in vivo.
|
30676763 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our study highlights the key role of HOTTIP and HOXA13 in HCC development by associating their expression with metastasis and survival in HCC patients, provides novel insights on the function of lncRNA-driven hepatocarcinogenesis, and paves the way for further investigation about the possible role of HOTTIP as a predictive biomarker of HCC.
|
24114970 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOTTIP silencing suppressed the growth of xenograft tumors.
|
30519045 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor growth in vivo was also suppressed after depletion of HOTTIP in a mouse model of lung cancer.
|
26265284 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that several well-known oncogenes, including H19, HOTTIP and Nespas, are significantly increased (6.3-1.8-fold), whereas tumor suppressors (Kcnq1ot1, lincRNA-p21) are decreased (up to 50-70%) in VDR deleted keratinocytes.
|
24342142 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we assayed the expression of HOTTIP in glioma tissue samples and glioma cell lines using real-time polymerase chain reaction and defined the biological functions of HOTTIP using the CCK-8 assay, flow cytometry, terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL assay) and tumour formation assay in a nude mouse model.
|
27733185 |
2016 |