|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice.
|
31786140 |
2019 |
|
Acute monocytic/monoblastic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HOTTIP was highly expressed in AML-M5 patients than normal controls.
|
31002141 |
2019 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
HOTTIP was validated as a prognostic marker for OS in the TCGA adenocarcinoma cohort (p = 0.025).
|
30819158 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By analyzing the normal and lung adenocarcinoma tissues from TCGA database and the treatment of sensitive and insensitive samples, we found that HOTTIP was overexpressed in lung adenocarcinoma and significantly increased in the treatment-insensitive group.
|
29272003 |
2017 |
|
Adult Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A long non-coding RNA named HOXA transcript at the distal tip (HOTTIP) has been reported to be significantly increased in several cancers, including hepatocellular cancer, pancreatic cancer and lung cancer.
|
28693275 |
2017 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HOTTIP is a critical modulator in human diseases including liver cancer, but its role and molecular biological mechanisms in liver fibrosis are still unclear.
|
30562760 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, other miRNAs and lncRNAs, such as HOTTIP and MALAT-1, have been shown to influence the malignant behavior of PDAC cells.
|
27060060 |
2016 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Among the most affected ncRNAs, we found that sorafenib mediated the dysregulation of the lncRNAs GAS5, HOTTIP and HOXA-AS2 and the miR-126-3p, in a panel of human cancer cell lines (HCC, renal and breast carcinomas).
|
31235746 |
2019 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Hence, HOTTIP may mediate, at least partly, HOXA11 expression involved in cell growth, migration, and apoptosis of breast cancer MCF-7 cells.
|
29415429 |
2018 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We observed a remarkable decrease in migration and invasiveness in these two breast cancer cell lines after knock-down of HOTTIP by shHOTTIP.
|
30676763 |
2019 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Finally, association between HOTTIP levels and clinicopathological factors and prognosis was also analyzed in an independent validation cohort including 100 breast cancer cases.
|
28036281 |
2017 |
|
Cancer of Nasopharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long Noncoding RNA HOTTIP Promotes Nasopharyngeal Cancer Cell Proliferation, Migration, and Invasion by Inhibiting miR-4301.
|
30685769 |
2019 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
These results elucidate that the miR-192/-204-HOTTIP axis might be an important molecular pathway during hepatic cell tumorigenesis.
|
26710269 |
2015 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The aim of this study was to elucidate the involvement of lncRNA HOTTIP in prostate cancer tumorigenesis and further investigate the role of HOXA13 in this process.
|
27064878 |
2016 |
|
Carcinogenesis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells.
|
28534516 |
2017 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
BACKGROUND The long noncoding RNA (lncRNA) HOTTIP is involved in gastric cancer tumorigenesis, papillary thyroid carcinoma, colorectal cancer, lung adenocarcinoma, and hepatocellular carcinoma, but it is unclear how HOTTIP exerts roles in nasopharyngeal carcinoma (NPC).
|
30685769 |
2019 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Functional assessment analysis revealed that HOTTIP might play a key role in the oncogenesis and progression of HNSCC.
|
31032351 |
2019 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Overall, we identified that HOTTIP was involved in SCLC tumorigenesis through the ceRNA network "HOTTIP/miR-574-5p/EZH1".
|
29041935 |
2017 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The HOXA transcript at the distal tip (HOTTIP) lncRNA plays an important role in carcinogenesis, however, the underlying role of HOTTIP in prostate cancer (PCa) remains unknown.
|
29884766 |
2018 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Long non‑coding RNA HOTTIP promotes hepatocellular carcinoma tumorigenesis and development: A comprehensive investigation based on bioinformatics, qRT‑PCR and meta‑analysis of 393 cases.
|
29039502 |
2017 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
In addition, HOTTIP knockdown inhibited the proliferation, invasion and migration in vitro together with in vivo tumorigenesis of PTC cells.
|
29474928 |
2018 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
HOXA transcript at the distal tip (HOTTIP) is a lncRNA that can be used as a prognostic marker in multiple carcinomas.
|
30519045 |
2018 |
|
Carcinoma of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
Tumor growth in vivo was also suppressed after depletion of HOTTIP in a mouse model of lung cancer.
|
26265284 |
2015 |
|
Carcinoma of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We found that patients with HOTTIP rs5883064 C allele or rs1859168 A allele had increased lung cancer risk (P = 0.01, P = 0.01, respectively).
|
26729200 |
2016 |
|
Carcinoma of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
A long non-coding RNA named HOXA transcript at the distal tip (HOTTIP) has been reported to be significantly increased in several cancers, including hepatocellular cancer, pancreatic cancer and lung cancer.
|
28693275 |
2017 |