|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Although there are over 110 genes mapped to the cadherin superfamily, our literature survey showed that evidence of association with psychiatric disorders is strongest for CDH7, CHD11, and CDH13.
|
28921840 |
2018 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, p49/p100 as well as p105 maps to regions associated with certain types of acute lymphoblastic leukemia.
|
1612589 |
1992 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
We identified thirteen loci showing significant differential DNA methylation levels between tumor and non-tumor lung; eight of these show highly significant hypermethylation in adenocarcinoma: CDH13, CDKN2A EX2, CDX2, HOXA1, OPCML, RASSF1, SFPR1, and TWIST1 (p-value < 0.0001).
|
17967182 |
2007 |
|
Adenocarcinoma
|
0.040 |
GeneticVariation
|
group |
LHGDN |
We identified thirteen loci showing significant differential DNA methylation levels between tumor and non-tumor lung; eight of these show highly significant hypermethylation in adenocarcinoma: CDH13, CDKN2A EX2, CDX2, HOXA1, OPCML, RASSF1, SFPR1, and TWIST1 (p-value < 0.0001).
|
17967182 |
2007 |
|
Adenocarcinoma
|
0.040 |
PosttranslationalModification
|
group |
LHGDN |
Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors.
|
18729198 |
2008 |
|
Adenocarcinoma
|
0.040 |
PosttranslationalModification
|
group |
BEFREE |
On the basis of the methylation profile, CRBP1 and CDH13 methylation were good indicators of CIMP in NSCLC, and were correlated with a poorer prognosis in adenocarcinomas.
|
16598760 |
2006 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Our major findings are a) methylation status of any single gene was largely independent of methylation status of other genes; b) the rates of methylation of p16 and APC and the mean Methylation Index (MI), a reflection of the overall methylation status, were significantly higher in ever smokers than in never smokers; c) the mean MI of tumors arising in former smokers was significantly lower than the mean of current smokers; d) the methylation rates of APC, CDH13 and RARbeta were significantly higher in adenocarcinomas than in squamous cell carcinomas; e) methylation rates of MGMT and GSTP1 were significantly higher in the USA and Australian cases than in those from Japan and Taiwan; and (f) no significant gender-related differences in methylation patterns were noted.
|
12455028 |
2003 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
CDH13 hypermethylation showed discriminative receiver-operator characteristic curve profiles, sharply demarcating esophageal adenocarcinoma (EAC) from esophageal squamous cell carcinoma (ESCC) and normal esophagus (NE) (p < 0.0001).
|
18729198 |
2008 |
|
Adenoma
|
0.030 |
PosttranslationalModification
|
group |
BEFREE |
It has recently become clear that CDH13 (H-cadherin, T-cadherin) expression is frequently silenced by aberrant methylation in colorectal cancers and adenomas.
|
14997203 |
2004 |
|
Adenoma
|
0.030 |
PosttranslationalModification
|
group |
LHGDN |
Here we confirmed the promoter activity of 5' region of CDH13 by luciferase assay and examined its aberrant methylation in colorectal cancers, cell lines, and adenomas.
|
12067979 |
2002 |
|
Adenoma
|
0.030 |
PosttranslationalModification
|
group |
BEFREE |
Here we confirmed the promoter activity of 5' region of CDH13 by luciferase assay and examined its aberrant methylation in colorectal cancers, cell lines, and adenomas.
|
12067979 |
2002 |
|
Adenoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Methylation of either CDH13 or CDH1 was identified in 35 cases (51%) and was more frequent in grade IV invasive adenomas than in grade I non-invasive adenomas (P<0.05 and P<0.05, respectively).
|
17873891 |
2007 |
|
Adenomatous Polyposis Coli
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The methylation frequencies of the genes tested in NSCLC specimens were 52% for E-cadherin (CDH1), 41% for RAS association domain family protein (RASSF1A), 38% for fragile histidine triad (FHIT) and adenomatous polyposis coli (APC), 27% for retinoic acid receptor beta (RARbeta) and H-cadherin (CDH13), 20% for p16INK4A, 0.8% for O6-methylguanine-DNA-methyltransferase (MGMT), and 0% for glutathione S-transferase P1 (GSTP1).
|
15042681 |
2004 |
|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
BEFREE |
We determined the frequency of aberrant promoter methylation of the p16, adenomatous polyposis coli (APC), H-cadherin (CDH13), glutathione S-transferase P1 (GSTP1), O6-methylguanine-DNA-methyltransferase (MGMT), retinoic acid receptor beta-2 (RAR beta), E-cadherin (CDH1), and RAS association domain family 1A (RASSF1A) genes in 198 tumors consisting of small cell lung cancers [SCLCs (n = 43)], non-small cell lung cancers [NSCLCs (n = 115)], and bronchial carcinoids (n = 40).
|
12467239 |
2001 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
22479202 |
2012 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
|
24105470 |
2014 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population.
|
22065538 |
2012 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population.
|
22065538 |
2012 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
22479202 |
2012 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Adiponectin concentrations: a genome-wide association study.
|
20887962 |
2010 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes.
|
21771975 |
2011 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
|
24105470 |
2014 |
|
Adiponectin Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes.
|
21771975 |
2011 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.
|
30395268 |
2018 |