|
Diabetic Retinopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, 10 single nucleotide polymorphisms (SNPs) in ADIPOQ and CDH13 susceptibility loci were associated with DR. Gene risk score (GRS) was calculated based on 10 SNPs for each subject and the cumulative effect of genes was observed.
|
30882695 |
2019 |
|
Stress, Psychological
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our behavioural findings indicate a role of CDH13 in the programming of and adaptation to early-life stress.
|
30165120 |
2019 |
|
Androgen-Insensitivity Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SNPs rs4513093 of CDH13 and rs687621 of ABO were found to be significantly associated with AIS with an odds ratio of 0.8691 and 1.203, respectively.
|
30994600 |
2019 |
|
Depressed mood
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, CDH13 is upregulated by chronic stress as well as in depression, suggesting a role in early-life adaptation to stressful experience.
|
30165120 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, because of the high frequency of methylation of the CDH13 gene in the early stages of ovarian cancer, the analyzed CpG sites might be good targets for next study of potential ovarian cancer screening biomarkers.
|
30368729 |
2019 |
|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Although there are over 110 genes mapped to the cadherin superfamily, our literature survey showed that evidence of association with psychiatric disorders is strongest for CDH7, CHD11, and CDH13.
|
28921840 |
2018 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
CDH13 abundance differs in mouse models according to their susceptibility to develop metabolic disorders, but the role of CDH13 in adipose tissue is unknown.
|
29467502 |
2018 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Together, our findings show that Cdh13 is critical for inhibitory function of Golgi cells, and that GlyT2::Cre-mediated deletion of Cdh13 in non-executive centers of the brain, such as the cerebellum, may contribute to cognitive and social behavioral deficits linked to neurological disorders.
|
29446202 |
2018 |
|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Although there are over 110 genes mapped to the cadherin superfamily, our literature survey showed that evidence of association with psychiatric disorders is strongest for CDH7, CHD11, and CDH13.
|
28921840 |
2018 |
|
Pervasive Development Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that Cadherin 13 (Cdh13), a gene implicated in autism spectrum disorder and attention-deficit hyperactivity disorder, is specifically expressed in Golgi cells within the cerebellar cortex.
|
29446202 |
2018 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An interaction is found between CDH13 SNP and diabetes for ischemic stroke.
|
28245897 |
2017 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
An interaction is found between CDH13 SNP and diabetes for ischemic stroke.
|
28245897 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two CDH13 polymorphisms were analysed in 1297 Caucasian subjects with type 1 diabetes from the 'Survival Genetic Nephropathy' (SURGENE) (n = 340, 10-year follow-up), 'Genesis France-Belgium' (GENESIS) (n = 501, 5-year follow-up for n = 462) and 'Génétique de la Néphropathie Diabétique' (GENEDIAB) (n = 456, 9-year follow-up for n = 283) cohorts.
|
28499019 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a cross-sectional analysis, CDH13 genotype distributions differed between those with and without T2D, with T2D odds ratios (OR) of 1.11 (95% CI: 1.04-1.18; P=0.001) and 0.92 (95% CI: 0.87-0.98; P=0.01) for rs11646213 and rs3865188, respectively.
|
27289142 |
2017 |
|
Diabetic Nephropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated associations between allelic variations of CDH13 and DN in subjects with type 1 diabetes.
|
28499019 |
2017 |
|
Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
T-cadherin gene variants are associated with nephropathy in subjects with type 1 diabetes.
|
28499019 |
2017 |
|
Kidney Failure, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CDH13 polymorphisms are also associated with the prevalence and incidence of DN, and with the incidence of ESRD in these patients.
|
28499019 |
2017 |
|
Tuberculosis, Pulmonary
|
0.010 |
Biomarker
|
disease |
BEFREE |
None of the SNPs achieved genome-wide significance; instead, we were able to replicate the associations between PTB and ten SNPs near or in the genes, CDCA7, GBE1, GADL1, SPATA16, C6orf118, KIAA1432, DMRT2, CTR9, CCDC67, and CDH13, which may play roles in the immune and inflammatory pathways.
|
28355295 |
2017 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke.
|
28245897 |
2017 |
|
Stimulant abuse
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Pharmacogenetics of stimulant abuse liability: association of CDH13 variant with amphetamine response in a racially-heterogeneous sample of healthy young adults.
|
27771748 |
2017 |
|
Neurodevelopmental Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Dysregulation of CDH13 expression may thus contribute to alterations in this system of neurotransmission, impacting cognitive function, which is frequently impaired in neurodevelopmental disorders including attention-deficit/hyperactivity and autism spectrum disorders.
|
29018333 |
2017 |
|
Chronic kidney disease stage 5
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CDH13 polymorphisms are also associated with the prevalence and incidence of DN, and with the incidence of ESRD in these patients.
|
28499019 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The results of subgroup analyses based on sample type suggested that CDH13 methylation was significantly associated with bladder cancer risk in both the tissue and the urine (OR = 53.94, P < 0.001; OR = 7.71, P < 0.001; respectively).
|
27578166 |
2016 |
|
Bladder Neoplasm
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The results of subgroup analyses based on sample type suggested that CDH13 methylation was significantly associated with bladder cancer risk in both the tissue and the urine (OR = 53.94, P < 0.001; OR = 7.71, P < 0.001; respectively).
|
27578166 |
2016 |
|
granulosa cell tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Hypermethylation of CDH13, DKK3 and FOXL2 promoters and the expression of EZH2 in ovary granulosa cell tumors.
|
27431680 |
2016 |