|
Myocardial Infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
We found that GDF11 reduced arrhythmia severity and successfully attenuated myocardial infarction; GDF11 also increased cardiac function after I-R, enhanced HO-1 expression and decreased oxidative damage.
|
30900023 |
2019 |
|
Myocardial Infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
TERT assists GDF11 to rejuvenate senescent VEGFR2<sup>+</sup>/CD133<sup>+</sup> cells in elderly patients with myocardial infarction.
|
31292540 |
2019 |
|
Myocardial Infarction
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Young (3 months) and old (21 months) mice were used to evaluate the expression of GDF11 mRNA in the myocardium at baseline and after ischemia/reperfusion (I/R) and myocardial infarction.
|
28004242 |
2017 |
|
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
High fat diet (HFD)-induced obesity was employed to examine the impacts of Gdf11 gene transfer on HFD-induced adiposity, hyperglycemia, insulin resistance, and hepatic lipid accumulation.
|
31847906 |
2019 |
|
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
Moreover, no significant differences in circulating concentrations of GDF11 regarding obesity or glycemic status were found.
|
30897065 |
2019 |
|
Obesity
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We firstly confirmed that the expression of GDF11 decreased both in the skeletal muscle of obese mice and palmitate-treated myotubes, but supplementation GDF11 does not ameliorate the palmitate-induced insulin resistance in C2C12 myotubes.
|
28485800 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Since its discovery in 1999, studies have shown the involvement of GDF11 in normal physiological processes, such as embryonic development and erythropoiesis, as well as in the pathophysiology of aging, cardiovascular disease, diabetes mellitus, and cancer.
|
29113418 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001).
|
17912435 |
2007 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
This review is focused to present and analyze the recent findings in the emerging research field of GDF11 function in cancer and metabolism, and discusses the controversies surrounding the biology of this atypical growth factor.
|
31681577 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.030 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11, a member of the transforming growth factor-β superfamily, has been reported to be involved in colorectal cancer.
|
29545874 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.030 |
Biomarker
|
disease |
BEFREE |
Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11.
|
30889293 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.030 |
Biomarker
|
disease |
BEFREE |
Although multivariate analysis showed that GDF11 was not an independent prognostic factor, these findings suggest that GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer.
|
17912435 |
2007 |
|
Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
This suggests an impaired GDF11 response contributing to anemia in AA patients.
|
30727851 |
2019 |
|
Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prior studies suggested that inhibition of growth differentiation factor 11 (GDF11) through soluble activin receptor type II (ActRII) ligand traps or neutralizing antibodies promotes erythroid precursor cell maturation and red blood cell formation in contexts of homeostasis and anemia.
|
31530563 |
2019 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined.
|
30188752 |
2018 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We concluded that adeno-associated viruses-GDF11 and recombinant GDF11 protect against endothelial injury and reduce atherosclerosis in apolipoprotein E<sup>-/-</sup> mice, thus may be providing a novel approach to the treatment of atherosclerosis.
|
27502608 |
2016 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We concluded that adeno-associated viruses-GDF11 and recombinant GDF11 protect against endothelial injury and reduce atherosclerosis in apolipoprotein E<sup>-/-</sup> mice, thus may be providing a novel approach to the treatment of atherosclerosis.
|
27502608 |
2016 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined.
|
30188752 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GDF11 repletion may improve β-cell function and mass and thus may lead to a new therapeutic approach for T2D.
|
28450417 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes.
|
30897065 |
2019 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
|
30942402 |
2019 |
|
Heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Recently, targeted myocardial delivery of the GDF11 gene in aged mice was found to reduce heart failure and enhance the proliferation of cardiac progenitor cells after myocardial ischemia-reperfusion (I-R).
|
30900023 |
2019 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
|
30942402 |
2019 |
|
Congestive heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Recently, targeted myocardial delivery of the GDF11 gene in aged mice was found to reduce heart failure and enhance the proliferation of cardiac progenitor cells after myocardial ischemia-reperfusion (I-R).
|
30900023 |
2019 |
|
Metabolic Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
As such, GDF11 could be considered as an important therapeutic candidate for age-related neurodegenerative and metabolic disorders.
|
31637864 |
2020 |