|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes.
|
30897065 |
2019 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
|
30942402 |
2019 |
|
Heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Recently, targeted myocardial delivery of the GDF11 gene in aged mice was found to reduce heart failure and enhance the proliferation of cardiac progenitor cells after myocardial ischemia-reperfusion (I-R).
|
30900023 |
2019 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
|
30942402 |
2019 |
|
Congestive heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Recently, targeted myocardial delivery of the GDF11 gene in aged mice was found to reduce heart failure and enhance the proliferation of cardiac progenitor cells after myocardial ischemia-reperfusion (I-R).
|
30900023 |
2019 |
|
Osteoporosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
FTO was up-regulated in bone marrow during aging or osteoporosis in human and mice in a GDF11(growth differentiation factor 11)-C/EBPα-dependent mechanism.
|
30279140 |
2018 |
|
Osteoporosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GDF11 level is significantly decreased in the plasma and bone marrow of aging mice and mice with osteoporosis.
|
25534870 |
2015 |
|
Agenesis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We show that GDF11 is cleaved and activated by PCSK5A, but not by PCSK5A-C470R, and that Gdf11-deficient embryos, in addition to having anteroposterior patterning defects and renal and palatal agenesis, also have a presacral mass, anorectal malformation, and exomphalos.
|
18519639 |
2008 |
|
Primary Myelofibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Luspatercept (and sotatercept), ligand traps that particularly inhibit GDF11, lead to RBC transfusion independence in 10% to 50% of lower-risk MDSs resistant to available treatments, and have started to be used in PMF.
|
30602619 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition to being significantly elevated in ALS CSF, these cytokines negatively correlated with the disease duration, whereas GDF11 was a favorable predictor of ALS clinical score.
|
28170441 |
2017 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Correspondingly, TSA treatment was shown to decrease GDF11 expression and reverse CASMC dedifferentiation in the partial ligated carotid artery of mice.
|
30462553 |
2019 |
|
Aplastic Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GDF11 is increased in patients with aplastic anemia.
|
30727851 |
2019 |
|
Anorexia Nervosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum GDF8, GDF11 and BMD were determined in 25 girls (12-16 years old) with AN and 31 healthy girls (12-16 years old).
|
30281844 |
2019 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study presents GDF11 as a potential target for the treatment of inflammatory arthritis, including RA.-Li, W., Wang, W., Liu, L., Qu, R., Chen, X., Qiu, C., Li, J., Hayball, J., Liu, L., Chen, J., Wang, X., Pan, X., Zhao, Y. GDF11 antagonizes TNF-α-induced inflammation and protects against the development of inflammatory arthritis in mice.
|
30407878 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study presents GDF11 as a potential target for the treatment of inflammatory arthritis, including RA.-Li, W., Wang, W., Liu, L., Qu, R., Chen, X., Qiu, C., Li, J., Hayball, J., Liu, L., Chen, J., Wang, X., Pan, X., Zhao, Y. GDF11 antagonizes TNF-α-induced inflammation and protects against the development of inflammatory arthritis in mice.
|
30407878 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
PCSK5 reconstitution mobilizes the latent TNBC reservoir of GDF11 in vitro and suppresses triple-negative mammary cancer metastasis to the lung of syngeneic hosts.
|
29161592 |
2017 |
|
Hypertrophic Cardiomyopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the current study aimed to examine the effects of GDF11 on ANG II-induced hypertrophic cardiomyopathy and expression of ANP, BNP and beta-MHC in mice, and explore possible molecular mechanisms.
|
30714521 |
2018 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, in addition to its role in aging, the relationship between GDF11 and cerebral ischemia is still an important area that needs more investigation.
|
29432795 |
2018 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our aim is to determine whether GDF11 has an effect on attenuating experimental colitis in mice.
|
30188752 |
2018 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, our research shows that GDF11 alleviates DSS-induced colitis by inhibiting NLRP3 inflammasome activation, providing some basis for its potential use in the treatment of UC.
|
30188752 |
2018 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the functions of GDF11 in myocardial ischaemia/reperfusion have not been elucidated yet.
|
27565745 |
2017 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, GDF11 may represent a promising molecular target for the prevention and treatment of psoriasis-like skin inflammation.
|
30259241 |
2019 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GDF11 repletion may enhance EPC resistance to diabetes-induced damage, improve angiogenesis, and thus, increase blood flow.
|
30026260 |
2018 |
|
Kidney Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Systemic, high-dose GDF11 administration in adult mice led to renal failure, with accompanying kidney atrophy, interstitial fibrosis, epithelial-to-mesenchymal transition of renal tubular cells, and eventually death.
|
29731246 |
2018 |
|
Uremia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The latest studies have shown that the level of circulating GDF 11 correlates with the outcomes of patients with cardiovascular diseases, cancer and uremia.
|
28223232 |
2017 |