|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined.
|
30188752 |
2018 |
|
Osteoporosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
FTO was up-regulated in bone marrow during aging or osteoporosis in human and mice in a GDF11(growth differentiation factor 11)-C/EBPα-dependent mechanism.
|
30279140 |
2018 |
|
Cerebrovascular accident
|
0.020 |
Biomarker
|
group |
BEFREE |
Here we examined effects of GDF11 on angiogenesis and recovery of neurological function in a rat model of stroke.
|
29432795 |
2018 |
|
Cerebrovascular accident
|
0.020 |
AlteredExpression
|
group |
BEFREE |
<b>Results:</b> GDF11 was upregulated in the ipsilateral peri-infarct cortex and subventricular zone (SVZ) at 14 days after stroke.
|
30061815 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of GDF11 in PANC-1 cells repressed the proliferation, migration and invasion abilities in vitro.
|
30568460 |
2018 |
|
Liver regeneration disorder
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Collectively, rather than acting as a rejuvenating agent, GDF11 worsens hepatocellular injury and impairs liver regeneration after IRI.-Liu, A., Dong, W., Peng, J., Dirsch, O., Dahmen, U., Fang, H., Zhang, C., Sun, J.
|
29913561 |
2018 |
|
MYELODYSPLASTIC SYNDROME
|
0.020 |
Biomarker
|
group |
BEFREE |
In the present study, we show that iron overload impairs the frequency and colony-forming capacity of normal hematopoietic stem and progenitor cells, especially in erythroid, in MDS mice, which is due, at least in part, to growth differentiation factor 11-induced reactive oxygen species, shortening survival of MDS mice.
|
29903757 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GDF11 repletion may improve β-cell function and mass and thus may lead to a new therapeutic approach for T2D.
|
28450417 |
2017 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We concluded that adeno-associated viruses-GDF11 and recombinant GDF11 protect against endothelial injury and reduce atherosclerosis in apolipoprotein E<sup>-/-</sup> mice, thus may be providing a novel approach to the treatment of atherosclerosis.
|
27502608 |
2016 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We concluded that adeno-associated viruses-GDF11 and recombinant GDF11 protect against endothelial injury and reduce atherosclerosis in apolipoprotein E<sup>-/-</sup> mice, thus may be providing a novel approach to the treatment of atherosclerosis.
|
27502608 |
2016 |
|
Osteoporosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GDF11 level is significantly decreased in the plasma and bone marrow of aging mice and mice with osteoporosis.
|
25534870 |
2015 |
|
Primary Myelofibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Luspatercept (and sotatercept), ligand traps that particularly inhibit GDF11, lead to RBC transfusion independence in 10% to 50% of lower-risk MDSs resistant to available treatments, and have started to be used in PMF.
|
30602619 |
2019 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Correspondingly, TSA treatment was shown to decrease GDF11 expression and reverse CASMC dedifferentiation in the partial ligated carotid artery of mice.
|
30462553 |
2019 |
|
Aplastic Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GDF11 is increased in patients with aplastic anemia.
|
30727851 |
2019 |
|
Anorexia Nervosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum GDF8, GDF11 and BMD were determined in 25 girls (12-16 years old) with AN and 31 healthy girls (12-16 years old).
|
30281844 |
2019 |
|
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We found that GDF11 reduced arrhythmia severity and successfully attenuated myocardial infarction; GDF11 also increased cardiac function after I-R, enhanced HO-1 expression and decreased oxidative damage.
|
30900023 |
2019 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study presents GDF11 as a potential target for the treatment of inflammatory arthritis, including RA.-Li, W., Wang, W., Liu, L., Qu, R., Chen, X., Qiu, C., Li, J., Hayball, J., Liu, L., Chen, J., Wang, X., Pan, X., Zhao, Y. GDF11 antagonizes TNF-α-induced inflammation and protects against the development of inflammatory arthritis in mice.
|
30407878 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study presents GDF11 as a potential target for the treatment of inflammatory arthritis, including RA.-Li, W., Wang, W., Liu, L., Qu, R., Chen, X., Qiu, C., Li, J., Hayball, J., Liu, L., Chen, J., Wang, X., Pan, X., Zhao, Y. GDF11 antagonizes TNF-α-induced inflammation and protects against the development of inflammatory arthritis in mice.
|
30407878 |
2019 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, GDF11 may represent a promising molecular target for the prevention and treatment of psoriasis-like skin inflammation.
|
30259241 |
2019 |
|
Heart Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
GDF11 levels were not related to the presence of hypertension or cardiopathy.
|
31248139 |
2019 |
|
Hypertensive disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
GDF11 levels were not related to the presence of hypertension or cardiopathy.
|
31248139 |
2019 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decline in circulating count and survival of VEGFR2<sup>+</sup>/CD133<sup>+</sup> cells with age was accompanied by decrease in their TERT and GDF11 expression levels in patients with AMI.
|
31292540 |
2019 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We also demonstrate that CRC-associated human intestinal lymphatic endothelial cells regulate tumor cell growth via growth differentiation factor 11, a soluble matrisome component which in CRC patients was found to be associated with tumor progression.
|
30889293 |
2019 |
|
Uveal melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High GDF11 expression was associated with uveal melanoma in advanced stages (IV), epithelioid cell dominant subtype, as well as extrascleral extension.
|
30883611 |
2019 |
|
Fibrosis, Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We showed that the expression of GDF11 is upregulated in patients with liver fibrosis and in experimentally induced murine liver fibrosis models.
|
31767630 |
2019 |