|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the ABL kinase inhibitor imatinib mesylate (Gleevec) provides highly effective treatment for BCR-ABL-positive chronic myelogenous leukemia, it has proven far less efficacious in the treatment of BCR-ABL-positive acute lymphoblastic leukemias (ALLs), many of which sustain deletions of the INK4A-ARF (CDKN2A) tumor suppressor locus.
|
16618932 |
2006 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the importance of the ARF tumor suppressor in p53 regulation is well established, numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2-independent manner.
|
15989956 |
2005 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
At the conclusion of this learning activity, participants should be familiar with the historical aspects of melanoma genetics and should have a greater understanding of the CDKN2A(p16)/ARF tumor suppressor genes.
|
10775844 |
2000 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both tumors develop in mice upon conditional deletion in melanocytes of Ink4a/Arf tumor suppressor genes with concomitant expression of oncogene H-Ras(G12V) and a known tumor antigen.
|
23173060 |
2012 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus.
|
17374722 |
2007 |
|
Acute respiratory failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus.
|
20723236 |
2010 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deletion of the INK4a/ARF tumor suppressor locus and trisomy 3 also occurred almost exclusively in ABC DLBCLs and was associated with inferior outcome within this subtype.
|
18765795 |
2008 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dual inactivation of PTEN and INK4a/ARF tumor suppressor genes is a common feature observed in a broad spectrum of human cancer types.
|
11818530 |
2002 |
|
Acute respiratory failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the ARF tumor suppressor is regulated by runt-related X1, suggesting that the inv(16) fusion protein (IFP) may repress ARF expression.
|
16199529 |
2005 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the ability of ATRA to induce senescence is reduced in p14(ARF)-depleted melanocytes, and we provide proof-of-concept that ATRA can induce irreversible growth arrest in melanoma cells with an intact RARβ-p14(ARF) signaling axis, independent of p16(INK4A) and p53 status.
|
23851445 |
2013 |
|
Acute respiratory failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of large T-ALL cohorts has not been carried out.
|
28671688 |
2017 |
|
Acute respiratory failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we show that the Wnt-effector Tcf1 is recruited to and triggers transcription of the Ink4/Arf tumor suppressor locus.
|
28346462 |
2017 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, genetic analysis of coincident loss of Pten and Ink4a/Arf tumor suppressors in the mouse revealed a neoplastic phenotype dominated by a premalignant expansion of biphenotypic myelolymphoid cells followed by the development of HS.
|
16697958 |
2006 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC.
|
26024833 |
2015 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, in acute myeloid leukaemia (AML) alterations of the INK4a-ARF tumour suppressor locus are rarely found despite the noted variable p16INK4a mRNA and protein levels.
|
11697625 |
2002 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human malignant mesotheliomas accumulate multiple somatic genetic alterations, including inactivation of the NF2 and CDKN2A/ARF tumor suppressor genes.
|
16166281 |
2005 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, these data establish that the ARF-E2F-1 pathway is an extension of the p53-mdm2-ARF tumor suppressor network and is unlikely to constitute a p53-independent pathway for ARF function.
|
17630509 |
2007 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Europe and North America, between 8-14% of melanoma patients have a family history of the disease, and a subset of these individuals possess germline mutations in the CDKN2A gene, which encodes the p16(INK4A) and p14(ARF) tumor suppressors.
|
17713569 |
2008 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we report for the first time that oncogenic H-ras signaling can trigger a senescence-like growth arrest in tumor cells, independent of the p16 and ARF tumor suppressors.
|
15492501 |
2004 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDM2 and P14/ARF (CDKN2A) are upstream regulators of TP53 and may contribute to its inactivation.
|
26918730 |
2016 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modeling INK4/ARF tumor suppression in the mouse.
|
17311533 |
2007 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in TP53, PTEN, PIK3CA, CTNNB1/beta-catenin genes and deletion of CDKN2A-ARF (p14(ARF)-p16(NK4a I) ) locus were investigated in sixteen primary primary effusion lymphoma tumors and seven primary effusion lymphoma cell lines using PCR and sequencing.
|
19608668 |
2009 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of the 747 patients (447 with acute respiratory failure [ARF]), 21.3% had a virus detected (56.4% rhinovirus/enterovirus and 30.7% influenza/parainfluenza/respiratory syncytial viruses).
|
30230909 |
2019 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, somatic mutation of the INK4a/ARF tumor suppressor locus, resulting in functionally deficient p16 and possibly p14(ARF) proteins, seems to be a prevalent event in the development of SCCHN.Mol.Carcinog.30:26-36, 2001.
|
11255261 |
2001 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors.
|
15029199 |
2004 |