|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of the 747 patients (447 with acute respiratory failure [ARF]), 21.3% had a virus detected (56.4% rhinovirus/enterovirus and 30.7% influenza/parainfluenza/respiratory syncytial viruses).
|
30230909 |
2019 |
|
Acute respiratory failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of large T-ALL cohorts has not been carried out.
|
28671688 |
2017 |
|
Acute respiratory failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we show that the Wnt-effector Tcf1 is recruited to and triggers transcription of the Ink4/Arf tumor suppressor locus.
|
28346462 |
2017 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDM2 and P14/ARF (CDKN2A) are upstream regulators of TP53 and may contribute to its inactivation.
|
26918730 |
2016 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands.
|
26351750 |
2015 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC.
|
26024833 |
2015 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The INK4a/ARF tumor suppressor gene locus is one of the major targets of Bmi-1.
|
24552182 |
2014 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transduction of primary blast cells from chronic myeloid leukemia in blast crisis (CML-BC) and Ph-positive acute lymphoblastic leukemia (ALL) with p16(INK4a) or p14(ARF) virus also resulted in cell growth inhibition and/or apoptosis with a patient-to-patient variation, whereas clonal growth and differentiation of cord blood progenitor cells were not affected by enforced expression of INK4a/ARF.
|
24330849 |
2013 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the ability of ATRA to induce senescence is reduced in p14(ARF)-depleted melanocytes, and we provide proof-of-concept that ATRA can induce irreversible growth arrest in melanoma cells with an intact RARβ-p14(ARF) signaling axis, independent of p16(INK4A) and p53 status.
|
23851445 |
2013 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both tumors develop in mice upon conditional deletion in melanocytes of Ink4a/Arf tumor suppressor genes with concomitant expression of oncogene H-Ras(G12V) and a known tumor antigen.
|
23173060 |
2012 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study examined genetic variants in the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene that encodes the p16(INK4a) and p14(ARF) tumor suppressors, and the isocitrate dehydrogenase 1 (IDH1) gene as potential markers of survival for 40 individuals with NDTMM GBMs (telomerase negative and ALT negative by standard assays), 50 individuals with telomerase, and 17 individuals with ALT positive tumors.
|
22046342 |
2011 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether Fe-induced DSBs are more potently tumorigenic than gamma ray-induced breaks, we irradiated 'sensitized' murine astrocytes that were deficient in Ink4a and Arf tumor suppressors and injected the surviving cells subcutaneously into nude mice.
|
20663777 |
2010 |
|
Acute respiratory failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus.
|
20723236 |
2010 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in TP53, PTEN, PIK3CA, CTNNB1/beta-catenin genes and deletion of CDKN2A-ARF (p14(ARF)-p16(NK4a I) ) locus were investigated in sixteen primary primary effusion lymphoma tumors and seven primary effusion lymphoma cell lines using PCR and sequencing.
|
19608668 |
2009 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that oncogenic Ras down-regulates C/EBPbeta expression in NIH 3T3 cells, which are immortalized by a deletion of the CDKN2A locus and, therefore, lack the p16(Ink4a) and p19(Arf) tumor suppressors.
|
19276382 |
2009 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The cytotoxicity of 5-aza-2'-deoxycytidine (DAC) has been linked to demethylation of the INK4a/ARF tumor suppressor gene locus in various cell systems, but the causality of this association remains unproven.
|
19372550 |
2009 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deletion of the INK4a/ARF tumor suppressor locus and trisomy 3 also occurred almost exclusively in ABC DLBCLs and was associated with inferior outcome within this subtype.
|
18765795 |
2008 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Europe and North America, between 8-14% of melanoma patients have a family history of the disease, and a subset of these individuals possess germline mutations in the CDKN2A gene, which encodes the p16(INK4A) and p14(ARF) tumor suppressors.
|
17713569 |
2008 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus.
|
17374722 |
2007 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also demonstrated that sonic hedgehog (Shh) expression, in cooperation with loss of the Trp53 and Ink4a/Arf tumor suppressor loci, was sufficient to initiate the formation of early pancreatic lesions.
|
17611415 |
2007 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, these data establish that the ARF-E2F-1 pathway is an extension of the p53-mdm2-ARF tumor suppressor network and is unlikely to constitute a p53-independent pathway for ARF function.
|
17630509 |
2007 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modeling INK4/ARF tumor suppression in the mouse.
|
17311533 |
2007 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, genetic analysis of coincident loss of Pten and Ink4a/Arf tumor suppressors in the mouse revealed a neoplastic phenotype dominated by a premalignant expansion of biphenotypic myelolymphoid cells followed by the development of HS.
|
16697958 |
2006 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the ABL kinase inhibitor imatinib mesylate (Gleevec) provides highly effective treatment for BCR-ABL-positive chronic myelogenous leukemia, it has proven far less efficacious in the treatment of BCR-ABL-positive acute lymphoblastic leukemias (ALLs), many of which sustain deletions of the INK4A-ARF (CDKN2A) tumor suppressor locus.
|
16618932 |
2006 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human malignant mesotheliomas accumulate multiple somatic genetic alterations, including inactivation of the NF2 and CDKN2A/ARF tumor suppressor genes.
|
16166281 |
2005 |