|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dual inactivation of PTEN and INK4a/ARF tumor suppressor genes is a common feature observed in a broad spectrum of human cancer types.
|
11818530 |
2002 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16(INK4a) and p14(ARF), whose functions are inactivated in many human cancers.
|
12117890 |
2002 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDM2 and P14/ARF (CDKN2A) are upstream regulators of TP53 and may contribute to its inactivation.
|
26918730 |
2016 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, genetic analysis of coincident loss of Pten and Ink4a/Arf tumor suppressors in the mouse revealed a neoplastic phenotype dominated by a premalignant expansion of biphenotypic myelolymphoid cells followed by the development of HS.
|
16697958 |
2006 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, in acute myeloid leukaemia (AML) alterations of the INK4a-ARF tumour suppressor locus are rarely found despite the noted variable p16INK4a mRNA and protein levels.
|
11697625 |
2002 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands.
|
26351750 |
2015 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transduction of primary blast cells from chronic myeloid leukemia in blast crisis (CML-BC) and Ph-positive acute lymphoblastic leukemia (ALL) with p16(INK4a) or p14(ARF) virus also resulted in cell growth inhibition and/or apoptosis with a patient-to-patient variation, whereas clonal growth and differentiation of cord blood progenitor cells were not affected by enforced expression of INK4a/ARF.
|
24330849 |
2013 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The accumulation and activity of p53 are positively controlled by the p14/ARF tumor suppressor and full restoration of the pathway in cancer cells may require that both p53 and p14ARF be supplied [corrected].
|
12839954 |
2003 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human malignant mesotheliomas accumulate multiple somatic genetic alterations, including inactivation of the NF2 and CDKN2A/ARF tumor suppressor genes.
|
16166281 |
2005 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether Fe-induced DSBs are more potently tumorigenic than gamma ray-induced breaks, we irradiated 'sensitized' murine astrocytes that were deficient in Ink4a and Arf tumor suppressors and injected the surviving cells subcutaneously into nude mice.
|
20663777 |
2010 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
At the conclusion of this learning activity, participants should be familiar with the historical aspects of melanoma genetics and should have a greater understanding of the CDKN2A(p16)/ARF tumor suppressor genes.
|
10775844 |
2000 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The INK4a/ARF tumor suppressor locus is implicated in the senescence-like growth arrest provoked by oncogenic Ras in primary cells.
|
12417717 |
2002 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC.
|
26024833 |
2015 |
|
Acute respiratory failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of large T-ALL cohorts has not been carried out.
|
28671688 |
2017 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the ability of ATRA to induce senescence is reduced in p14(ARF)-depleted melanocytes, and we provide proof-of-concept that ATRA can induce irreversible growth arrest in melanoma cells with an intact RARβ-p14(ARF) signaling axis, independent of p16(INK4A) and p53 status.
|
23851445 |
2013 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The INK4a-ARF (CDKN2A)- locus on chromosome 9p21 encodes for two tumour suppressor proteins, p16(INK4a) and p14(ARF), that act as upstream regulators of the Rb-CDK4 and p53 pathways.
|
11704835 |
2001 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of the 747 patients (447 with acute respiratory failure [ARF]), 21.3% had a virus detected (56.4% rhinovirus/enterovirus and 30.7% influenza/parainfluenza/respiratory syncytial viruses).
|
30230909 |
2019 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in TP53, PTEN, PIK3CA, CTNNB1/beta-catenin genes and deletion of CDKN2A-ARF (p14(ARF)-p16(NK4a I) ) locus were investigated in sixteen primary primary effusion lymphoma tumors and seven primary effusion lymphoma cell lines using PCR and sequencing.
|
19608668 |
2009 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the ABL kinase inhibitor imatinib mesylate (Gleevec) provides highly effective treatment for BCR-ABL-positive chronic myelogenous leukemia, it has proven far less efficacious in the treatment of BCR-ABL-positive acute lymphoblastic leukemias (ALLs), many of which sustain deletions of the INK4A-ARF (CDKN2A) tumor suppressor locus.
|
16618932 |
2006 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we report for the first time that oncogenic H-ras signaling can trigger a senescence-like growth arrest in tumor cells, independent of the p16 and ARF tumor suppressors.
|
15492501 |
2004 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both tumors develop in mice upon conditional deletion in melanocytes of Ink4a/Arf tumor suppressor genes with concomitant expression of oncogene H-Ras(G12V) and a known tumor antigen.
|
23173060 |
2012 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that oncogenic Ras down-regulates C/EBPbeta expression in NIH 3T3 cells, which are immortalized by a deletion of the CDKN2A locus and, therefore, lack the p16(Ink4a) and p19(Arf) tumor suppressors.
|
19276382 |
2009 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Ink4a/Arf tumor suppressor locus is widely inactivated in cancer but little is known about the tumor biology of its two products, p16(Ink4a) (p16) and Arf.
|
16322687 |
2005 |
|
Acute respiratory failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The INK4a-ARF (CDKN2A) locus, located on chromosome 9p21, encodes two functionally distinct tumor suppressor genes, p14ARF and p16INK4a, which play active roles in the p53 and Rb tumor suppressive pathways.
|
12924439 |
2003 |
|
Acute respiratory failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus.
|
17374722 |
2007 |