|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 genes.
|
15390181 |
2005 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report.
|
19770381 |
2009 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletions significantly affected event-free survival (EFS) of the ALL IC cohort (41 ± 14% vs. 86 ± 3%, P < 0.0001).
|
22997141 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia.
|
23804397 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan.
|
23930217 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 rs4132601 polymorphism and acute lymphoblastic leukemia susceptibility: a meta-analysis.
|
25012940 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletions were associated with B-cell precursor acute lymphoblastic leukemia (P=0.036), BCR-ABL1-positive acute lymphoblastic leukemia (P<0.001), and higher white blood cell counts (P=0.005).
|
25261097 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia.
|
26069293 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IKZF1 alterations and expression of CRLF2 predict prognosis in adult Chinese patients with B-cell precursor acute lymphoblastic leukemia.
|
27157479 |
2017 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletion was noted in nine B-ALL with t(9;22), one B-ALL with t(4;11), five B-ALL with a normal karyotype, and three B-ALL with nonrecurring karyotypic abnormalities.
|
27161658 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletion (ΔIKZF1) is an important predictor of relapse in childhood B-cell precursor acute lymphoblastic leukemia.
|
27419633 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IKZF1 and PAX5 deletions were observed in 13 and 17% of B-LBL, respectively, which was similar to the reported frequency in B-ALL.
|
27957801 |
2017 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletion and co-occurrence with other aberrations in a child with chronic myeloid leukemia progressing to acute lymphoblastic leukemia.
|
30511400 |
2019 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 rs4132601 and rs10272724 could be considered significant risk contributors to childhood acute lymphoblastic leukaemia and may impact the iron profiles in these children.
|
30806315 |
2019 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia.
|
30877974 |
2019 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 Gene Deletion in Pediatric Patients Diagnosed with Acute Lymphoblastic Leukemia in Mexico.
|
30974435 |
2019 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A subset of B-ALL patients with IKZF1 alterations have a transcriptional profile similar to BCR-ABL1-positive ALL, and these patients commonly have novel rearrangements and mutations resulting in aberrant cytokine receptor signaling and activation of kinase signaling cascades, including rearrangement of CRLF2 and activating mutations of Janus kinases (JAK1 and JAK2).
|
21149616 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
An 11-year-old male patient with the deletion of <i>IKZF1</i> (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(<i>BCR-ABL1</i>) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate.
|
31607921 |
2019 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.
|
24064621 |
2014 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells.
|
16205638 |
2006 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia.
|
23065506 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
By contrast, the MRD15 was higher in Ikaros family Zinc Finger Protein 1 (<i>IKZF1)</i>-deleted BCP-ALL patients than in BCP-ALL patients without <i>IKZF1</i> deletions [1.18% (0.06-12.0%) vs 0.33% (0.03-2.6%); p=0.003].
|
29899835 |
2018 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Children with the IKZF1 SNP had an increased risk of developing MLL-germline ALL in white children.
|
24564228 |
2014 |