Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 Gene Deletion in Pediatric Patients Diagnosed with Acute Lymphoblastic Leukemia in Mexico.
|
30974435 |
2019 |
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
An 11-year-old male patient with the deletion of <i>IKZF1</i> (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(<i>BCR-ABL1</i>) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate.
|
31607921 |
2019 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia.
|
30877974 |
2019 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 rs4132601 and rs10272724 could be considered significant risk contributors to childhood acute lymphoblastic leukaemia and may impact the iron profiles in these children.
|
30806315 |
2019 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletion and co-occurrence with other aberrations in a child with chronic myeloid leukemia progressing to acute lymphoblastic leukemia.
|
30511400 |
2019 |
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Common CNAs involved CDKN2A/2B (30.3%), IKZF1 (27.3%), PAX5 (9.1%), RB1 (9.1%), BTG1 (6.7%), and ETV6 (6.7%), which regulate cell cycle, B lymphopoiesis, or act as tumor suppressors in ALL.
|
31112375 |
2019 |
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CK2 inhibitor by increasing IKAROS activity significantly suppresses <i>RAG1</i> expression in ALL in an IKAROS-dependent manner.
|
31333801 |
2019 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.
|
31604453 |
2019 |
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia.
|
29519871 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate that the IKAROS promotes PHF2 expression, and suggest that PHF2 <sup>low</sup> expression works with the IKAROS gene deletion to drive oncogenesis of ALL.
|
28994305 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia.
|
29507076 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The multiplex ligation-dependent probe amplification (MLPA) method was used to detect the copy number alterations (CNAs) of IKAROS family zinc finger 1 (<i>IKZF1</i>), paired box 5 (<i>PAX5</i>), ETS variant 6 (<i>ETV6</i>), RB transcriptional corepressor 1 (<i>RB1</i>), BTG anti-proliferation factor 1 (<i>BTG1</i>), early B-cell factor 1 (<i>EBF1</i>), cyclin dependent kinase inhibitor 2A/2B (<i>CDKN2A/2B</i>) and cytokine receptor like factor 2 (<i>CRLF2</i>) genes in 87 adults with acute lymphoblastic leukemia (ALL) in China.
|
29552179 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Development of a Fluorescence in Situ Hybridization Probe for Detecting IKZF1 Deletion Mutations in Patients with Acute Lymphoblastic Leukemia.
|
29957452 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
By contrast, the MRD15 was higher in Ikaros family Zinc Finger Protein 1 (<i>IKZF1)</i>-deleted BCP-ALL patients than in BCP-ALL patients without <i>IKZF1</i> deletions [1.18% (0.06-12.0%) vs 0.33% (0.03-2.6%); p=0.003].
|
29899835 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Patients and Methods The analysis involved 991 patients with BCP ALL treated in the Associazione Italiana Ematologia ed Oncologia Pediatrica-Berlin-Frankfurt-Muenster (AIEOP-BFM) ALL 2000 trial with complete information for copy number alterations of IKZF1, PAX5, ETV6, RB1, BTG1, EBF1, CDKN2A, CDKN2B, Xp22.33/Yp11.31 (PAR1 region; CRLF2, CSF2RA, and IL3RA), and ERG; replication of findings involved 417 patients from the same trial.
|
29498923 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study.
|
30044693 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this issue of Cancer Cell, Churchman et al. add to the list of leukemia predisposition genes with the identification and characterization of germline IKZF1 variants in childhood ALL.
|
29763621 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results identify IKZF1 as a leukemia predisposition gene, and emphasize the importance of germline genetic variation in the development of both familial and sporadic ALL.
|
29681510 |
2018 |
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IKZF1 and PAX5 deletions were observed in 13 and 17% of B-LBL, respectively, which was similar to the reported frequency in B-ALL.
|
27957801 |
2017 |
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome.
|
28190000 |
2017 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The IKZF1 SNPs, rs10235796 and rs6964969, and the CDKN2A SNP rs3731246 (previously unreported) could serve as risk markers for ALL susceptibility in Yemeni children.
|
28768142 |
2017 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
|
27979924 |
2017 |
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IKZF1 alterations and expression of CRLF2 predict prognosis in adult Chinese patients with B-cell precursor acute lymphoblastic leukemia.
|
27157479 |
2017 |
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, IKZF1 deletion is associated with high BCL6 and low BACH2 expression in B-ALL patients.
|
28030830 |
2017 |
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent experimental mouse modeling of B-progenitor ALL has shown that IKZF1 alterations have multiple effects, including arresting differentiation, skewing lineage of leukemia from myeloid to lymphoid, and, in Ph+ leukemia, conferring resistance to tyrosine kinase inhibitor (TKI) therapy without abrogating ABL1 inhibition.
|
27865806 |
2017 |