|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CK2 inhibitor by increasing IKAROS activity significantly suppresses <i>RAG1</i> expression in ALL in an IKAROS-dependent manner.
|
31333801 |
2019 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Common CNAs involved CDKN2A/2B (30.3%), IKZF1 (27.3%), PAX5 (9.1%), RB1 (9.1%), BTG1 (6.7%), and ETV6 (6.7%), which regulate cell cycle, B lymphopoiesis, or act as tumor suppressors in ALL.
|
31112375 |
2019 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome.
|
28190000 |
2017 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations of IKZF1.
|
25727050 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CRLF2-d, IGH@-t, and IKZF1 deletions are associated with poor outcome in adolescent and adult ALL.
|
22851563 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Deletion of IKZF1 was also identified as an acquired lesion at the time of transformation of CML to ALL (lymphoid blast crisis).
|
18408710 |
2008 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Development of a Fluorescence in Situ Hybridization Probe for Detecting IKZF1 Deletion Mutations in Patients with Acute Lymphoblastic Leukemia.
|
29957452 |
2018 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia.
|
12028018 |
2002 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic alterations of the transcription factor IKZF1 ("IKAROS") are detected in around 15-30% of cases of <i>BCR-ABL</i>-negative B-cell precursor acute lymphoblastic leukemia.
|
28751559 |
2017 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion.
|
26404892 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ikaros (IKZF1) functions as a master regulator of hematopoiesis and a tumor suppressor in acute lymphoblastic leukemia (ALL).
|
26912004 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a high proportion of Philadelphia positive acute lymphoblastic leukaemia (ALL) patients, prognostically adverse deletions of the IKZF1 gene coding for a specific transcription factor were identified with GEP analysis, which revealed new insights in the clinical variability of this disorder.
|
20570445 |
2010 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, IKZF1 has been implicated in roles involved in some hematologic traits or abnormalities, such as erythrocyte measures, myelofibrosis, and acute lymphoblastic leukemia (ALL), which may be common clinical manifestations or co-occurrence hematological diseases of patients with SLE.
|
22782532 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the need of and benefit from introducing IKZF1 deletions as an additional stratification marker for patients with Philadelphia-negative B-cell precursor acute lymphoblastic leukemia remain questionable.
|
23585525 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this issue of Cancer Cell, Churchman et al. add to the list of leukemia predisposition genes with the identification and characterization of germline IKZF1 variants in childhood ALL.
|
29763621 |
2018 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we determined the prognostic significance of IKZF1 deletions in patients with childhood ALL.
|
21740479 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study.
|
30044693 |
2018 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, IKZF1 deletion is associated with high BCL6 and low BACH2 expression in B-ALL patients.
|
28030830 |
2017 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in genes regulating lymphoid development are a hallmark of ALL, and alterations of the lymphoid transcription factor gene IKZF1 (IKAROS) are associated with a high risk of treatment failure in B-ALL.
|
23233609 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Notably, genetic alteration of the lymphoid transcription factor gene IKZF1 is a hallmark of multiple subtypes of ALL with poor prognosis, including BCR-ABL1-positive lymphoid leukemia and a subset of 'BCR-ABL1-like' ALL cases that, in addition to IKZF1 alteration, harbor genetic mutations resulting in aberrant lymphoid cytokine receptor signaling, including activating mutations of Janus kinases and rearrangement of cytokine receptor-like factor 2 (CRLF2).
|
20739952 |
2010 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Notably, genetic alterations targeting transcriptional regulators of lymphoid development are a hallmark of B-progenitor ALL, and alteration of specific genes in this pathway, such as IKZF1 (encoding IKAROS), are associated with high-risk ALL.
|
21169835 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One recently identified subtype of pediatric B-precursor acute lymphoblastic leukemia (ALL) has been termed BCR-ABL1-like or Ph-like because of similarity of the gene expression profile to BCR-ABL1 positive ALL suggesting the presence of lesions activating tyrosine kinases, frequent alteration of IKZF1, and poor outcome.
|
23212523 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data also suggest that high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of ALL and has significance in an integrated prognostic model for adult high-risk ALL.
|
27391346 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate that the IKAROS promotes PHF2 expression, and suggest that PHF2 <sup>low</sup> expression works with the IKAROS gene deletion to drive oncogenesis of ALL.
|
28994305 |
2018 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations.
|
22441210 |
2012 |