|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DIL-1 (differentially expressed in cancerous and noncancerous lung cells; HGMW-approved symbol SPON2) and pulmonary surfactant apoprotein A were expressed in normal lung tissues but not in lung carcinoma cell lines, whereas DIL-2 (HGMW-approved symbol C20orf2) and nm23-H1 were expressed in lung carcinoma cell lines but not in normal lung tissues.
|
10512675 |
1999 |
|
Malignant neoplasm of prostate
|
0.310 |
Biomarker
|
disease |
CTD_human |
Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study.
|
19208208 |
2009 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study.
|
19208208 |
2009 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Together, these experimental findings suggest that spondin 2, which is regulated by T(3), has an important role in cell invasion, cell migration, and tumor progression.
|
19903741 |
2010 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion.
|
19903741 |
2010 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, this study demonstrated that spondin 2 overexpression in some types of hepatocellular carcinomas is TR dependent.
|
19903741 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
GeneChip Expression Analysis was employed to survey the glomerular gene expression profile in a type 2 diabetes (T2D) model of KK/Ta mice fed with a high-calorie diet (HC), and we focused on the role of mindin (also called spondin 2), whose expression is upregulated by HC.
|
21098016 |
2011 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Mindin/spondin 2, an extracellular matrix (ECM) component that belongs to the thrombospondin type 1 (TSR) class of molecules, plays prominent roles in the regulation of inflammatory responses, angiogenesis and metabolic disorders.
|
25751394 |
2015 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curve analysis demonstrated that plasma Spondin-2 has superior predictive performance for CRC with an area under the curve of 0.959 and the best sensitivity/specificity of 100%/90%.
|
25945835 |
2015 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spondin-2 could be an independent diagnostic and prognostic biomarker of colon cancer.
|
25945835 |
2015 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spondin-2 could be an independent diagnostic and prognostic biomarker of colon cancer.
|
25945835 |
2015 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Tumors with SPON2 overexpression induced liver metastasis (vs control animals without any metastases, P=0.0036).
|
26686083 |
2016 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In patients, SPON2 serves as prognostic indicator for CRC metastasis and survival, and might represent a promising target for therapeutic approaches.
|
26686083 |
2016 |
|
Secondary Neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Tumors with SPON2 overexpression induced liver metastasis (vs control animals without any metastases, P=0.0036).
|
26686083 |
2016 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumors with SPON2 overexpression induced liver metastasis (vs control animals without any metastases, P=0.0036).
|
26686083 |
2016 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The MACC1-SPON2 axis: a new biomarker and therapeutic target in colorectal cancer.
|
27669439 |
2017 |
|
Solid Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The MACC1/SPON2 axis may also have utility beyond an indicator of tumor aggressiveness and lends itself as a promising therapeutic target for colorectal and potentially other solid tumors.
|
27669439 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
The MACC1-SPON2 axis: a new biomarker and therapeutic target in colorectal cancer.
|
27669439 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The spondin-2 correlated with tumor progression in many malignancies.
|
28060752 |
2017 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, the role of spondin-2 in gastric cancer has not been thoroughly elucidated.
|
28060752 |
2017 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In conclusion, Spondin-2 overexpression contributes to tumor aggressiveness and prognosis, and could be a promising target for prognostic prediction in gastric cancer patients.
|
28060752 |
2017 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The spondin-2 correlated with tumor progression in many malignancies.
|
28060752 |
2017 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, the role of spondin-2 in gastric cancer has not been thoroughly elucidated.
|
28060752 |
2017 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Spondin-2 overexpression was significantly associated with well differentiation, depth of invasion, lymph node metastasis, and advanced TNM stages.
|
28060752 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of spondin-2 were increasing in both prominent serosal invasion group and lymph node metastasis group.
|
28060752 |
2017 |