|
Malignant neoplasm of prostate
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Serum BSP, Spondin-2, and PSA levels were highest in prostate cancer with bone metastasis, followed by no bone metastasis, hyperplasia, and control (p < 0.05).
|
28121355 |
2017 |
|
Malignant neoplasm of prostate
|
0.310 |
Biomarker
|
disease |
CTD_human |
Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study.
|
19208208 |
2009 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study.
|
19208208 |
2009 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
The results revealed that SPON2 was highly expressed in GC tissues from patients with relapse or metastasis.
|
31691494 |
2020 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis.
|
29440144 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, through univariate and multivariate regression analysis, we found that overexpression of SPON2 protein levels correlates with differentiation, positive lymph nodes metastasis, higher serum carcinoembryonic antigen (CEA) level and poor overall survival.
|
28938639 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Spon2 is a proto-oncogene matrix protein that plays an essential role in the tumorigenesis and metastasis of gastric cancer.
|
28772159 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Tumors with SPON2 overexpression induced liver metastasis (vs control animals without any metastases, P=0.0036).
|
26686083 |
2016 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The levels of SPON2 in sera of patients with GC were significantly higher compared with those of healthy individuals and patients with atrophic gastritis.
|
31691494 |
2020 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The levels of SPON2 in sera of patients with GC were significantly higher compared with those of healthy individuals and patients with atrophic gastritis.
|
31691494 |
2020 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.
|
31691494 |
2020 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Spondin 2 (SPON2), a member of the Mindin F-Spondin family, identifies pathogens, activates congenital immunity and promotes the growth and adhesion of neurons as well as binding to their receptors, but its role in promoting or inhibiting tumour metastasis is controversial.
|
31691494 |
2020 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Spondin-2, belongs to the SOX (SRY-related HMG box) gene family, plays a vital role in the development of malignancy, however, the role of Spondin-2 in laryngeal squamous cell carcinoma (LSCC) remains unknown.
|
30527359 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Upregulated expression of SPON2 protein in tumor tissue could be an effective prognostic indicator for patients with HCC.
|
30318967 |
2019 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Upregulated expression of SPON2 protein in tumor tissue could be an effective prognostic indicator for patients with HCC.
|
30318967 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.<b>Significance:</b> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg <i>Cancer Res; 78(9); 2305-17.©2018 AACR</i>.
|
29440144 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.<b>Significance:</b> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg <i></i>.
|
29440144 |
2018 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have shown that SPON2 has complicated roles in cell migration and tumor progression.
|
29440144 |
2018 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.<b>Significance:</b> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg <i></i>.
|
29440144 |
2018 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis.
|
29440144 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The spondin-2 correlated with tumor progression in many malignancies.
|
28060752 |
2017 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The MACC1-SPON2 axis: a new biomarker and therapeutic target in colorectal cancer.
|
27669439 |
2017 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
Structure-based design of competitive ligands to target Spon2 in gastric cancer: An integration of molecular modeling and in vitro assay.
|
28772159 |
2017 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, the role of spondin-2 in gastric cancer has not been thoroughly elucidated.
|
28060752 |
2017 |