|
Malignant neoplasm of prostate
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Serum BSP, Spondin-2, and PSA levels were highest in prostate cancer with bone metastasis, followed by no bone metastasis, hyperplasia, and control (p < 0.05).
|
28121355 |
2017 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
The diagnostic significances of BSP, Spondin-2, and PSADT on bone metastasis were evaluated by ROC curve.
|
28121355 |
2017 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum BSP, Spondin-2, and PSA levels were highest in prostate cancer with bone metastasis, followed by no bone metastasis, hyperplasia, and control (p < 0.05).
|
28121355 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Spon2 is a proto-oncogene matrix protein that plays an essential role in the tumorigenesis and metastasis of gastric cancer.
|
28772159 |
2017 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
Structure-based design of competitive ligands to target Spon2 in gastric cancer: An integration of molecular modeling and in vitro assay.
|
28772159 |
2017 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Structure-based design of competitive ligands to target Spon2 in gastric cancer: An integration of molecular modeling and in vitro assay.
|
28772159 |
2017 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Spon2 is a proto-oncogene matrix protein that plays an essential role in the tumorigenesis and metastasis of gastric cancer.
|
28772159 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, through univariate and multivariate regression analysis, we found that overexpression of SPON2 protein levels correlates with differentiation, positive lymph nodes metastasis, higher serum carcinoembryonic antigen (CEA) level and poor overall survival.
|
28938639 |
2017 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data revealed that SPON2 played an oncogene role in ADC development and progression.
|
28938639 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis.
|
29440144 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.<b>Significance:</b> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg <i>Cancer Res; 78(9); 2305-17.©2018 AACR</i>.
|
29440144 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.<b>Significance:</b> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg <i></i>.
|
29440144 |
2018 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have shown that SPON2 has complicated roles in cell migration and tumor progression.
|
29440144 |
2018 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.<b>Significance:</b> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg <i></i>.
|
29440144 |
2018 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis.
|
29440144 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.<b>Significance:</b> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg <i>Cancer Res; 78(9); 2305-17.©2018 AACR</i>.
|
29440144 |
2018 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In an article published recently in <i>Clinical Science</i> (vol 132, issue 6, 1199-1213), Zhang and colleagues identified the extracellular matrix protein mindin/spondin 2 as a positive regulator of atherosclerosis.
|
30037838 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In an article published recently in <i>Clinical Science</i> (vol 132, issue 6, 1199-1213), Zhang and colleagues identified the extracellular matrix protein mindin/spondin 2 as a positive regulator of atherosclerosis.
|
30037838 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The results suggest that SP-2, an uremic toxin, might be effective over a complex pathway in the inflammatory process and in the pathogenesis of cardiovascular diseases of patients under HD treatment.
|
30276603 |
2018 |
|
Hodgkin Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We aimed to determine the relation between serum SP-2 levels and cardiac morphology along with inflammatory parameters in hemodialysis (HD) patients.
|
30276603 |
2018 |
|
Huntington Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We aimed to determine the relation between serum SP-2 levels and cardiac morphology along with inflammatory parameters in hemodialysis (HD) patients.
|
30276603 |
2018 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Upregulated expression of SPON2 protein in tumor tissue could be an effective prognostic indicator for patients with HCC.
|
30318967 |
2019 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Upregulated expression of SPON2 protein in tumor tissue could be an effective prognostic indicator for patients with HCC.
|
30318967 |
2019 |
|
Tumor thrombus
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Multivariate Cox regression analysis showed that tumor thrombus and SPON2 protein expression both independently correlated with reduced survival in HCC patients.
|
30318967 |
2019 |