|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
A therapeutic cancer vaccine targeting carcinoembryonic antigen in intestinal carcinomas.
|
18937552 |
2009 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
This system may be useful in gene therapy that targets CEA-producing gastric carcinomas.
|
8898638 |
1996 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is a potential target for antigen-specific immunotherapy, as it is frequently overexpressed in human carcinomas.
|
20386466 |
2010 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The intensity of signal appeared to be stronger in carcinomas than that in adenomas, and the CEA and NCA mRNAs were expressed together in most of the positive tissue specimens.
|
2125040 |
1990 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that PCR amplification of CEA mRNA may lead to an earlier diagnosis of micrometastatic bone disease in patients with CEA-expressing carcinomas.
|
7512130 |
1994 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
CEA concentrations exceeding 5 ng/mL cut-off point indicated carcinomas, regardless of pleural involvement, which gave a sensitivity of 62% and specificity of 100% for carcinoma.
|
31028099 |
2019 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Downregulation of carcinoembryonic antigen-related cell adhesion molecule (CEACAM1), a cell adhesion molecule with tumor suppressing properties has been observed in a high percentage of carcinomas of the endometrium and other malignancies.
|
16332726 |
2006 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, slightly higher CEA-specific T cell responses were observed in cancer patients with CEA-expressing carcinomas than in healthy blood donors.
|
11129322 |
2000 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
AA-Cur elicited moderate anti-tumor activity toward colon MC38-CEA or breast 4T1 carcinomas.
|
31564877 |
2019 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is expressed on human colon carcinomas, is well characterized, and continues to be a promising target for cancer immunotherapy in humans.
|
18812201 |
2008 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Construction, expression and characterization of a dual cancer-specific fusion protein targeting carcinoembryonic antigen in intestinal carcinomas.
|
19686851 |
2010 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The objective of this study was both to design recombinant vectors in which the suicide gene E. coli purine nucleoside phosphorylase (ePNP) is under the control of either CEA or MUC1 promoter sequences and to investigate on experimental pancreatic carcinomas the selective killing effects of the conditional ePNP/prodrug (MePdR) system.
|
15580629 |
2005 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When we compared the intensity of the hybridization signal for CEA or NCA mRNA among adenomas, carcinomas and adjacent noninvaded tissues, NCA mRNA rather than CEA mRNA was highly expressed in carcinomas compared to adjacent nonivaded tissues.
|
2067130 |
1991 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings suggest that mammaglobin B and CEA could be useful RT-PCR markers for the detection of lymph node micrometastases in biliary tract carcinomas.
|
10873083 |
2000 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) has been suggested as a metastatic activator in colorectal carcinoma, whereas the E-cadherin expression is downregulated in a variety of carcinomas.
|
14592671 |
2003 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The present approach to manipulating antigen presentation may open new possibilities for immunotherapy against colon and other CEA-secreting carcinomas.
|
12719706 |
2003 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
A phase I study of recombinant (r) vaccinia-CEA(6D)-TRICOM and rFowlpox-CEA(6D)-TRICOM vaccines with GM-CSF and IFN-α-2b in patients with CEA-expressing carcinomas.
|
27581603 |
2016 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
However, assays of the tissue CEA content in six histologically verified adenomas showed values similar to those of overt colonic carcinomas.
|
1202622 |
1975 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To detect adenocarcinoma cells in the circulating peripheral blood, we "analyzed the presence of carcinoembryonic antigen (CEA) mRNA in the peripheral blood obtained from patients with pancreatic carcinoma (PC) or with gastric carcinoma (GC) and also, as controls, from pancreatitis or gastritis patients without carcinomas, a gastric lymphoma patient and four healthy volunteers.
|
8950323 |
1996 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Definition of the expression of the human carcinoembryonic antigen and non-specific cross-reacting antigen in human breast and lung carcinomas.
|
8386136 |
1993 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Similarly to the 180 kd CEA molecules synthesized by carcinomas, the expression of the melanoma associated CEA like components (MA-CEA) is upregulated by IFN-alpha.
|
3235849 |
1989 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas CEA is a suitable marker for aneuploid carcinomas, other more sensitive tumour markers should be sought for diploid and also for tetraploid tumours.
|
1771385 |
1991 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
CEA is an important tumor marker for colorectal and some other carcinomas.
|
10202129 |
1999 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the newly identified helper T-cell epitope was found to overlap with a previously described HLA-A24-restricted CTL epitope, CEA(652-660), which could facilitate the development of a therapeutic vaccine capable of eliciting both CTL and T helper responses in patients suffering from epithelial carcinomas.
|
12374692 |
2002 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunodiffusion of perchloric acid extracts of CEA-like material from heterozygote carrier blood indicated that the CEA-like material, which was elevated in homozygotes and heterozygotes for CF, showed only partial identity with two separate CEA preparations obtained from colon carcinomas and was not identical to either A, B, or O(H) blood group substances.
|
824719 |
1976 |