Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
However, assays of the tissue CEA content in six histologically verified adenomas showed values similar to those of overt colonic carcinomas.
|
1202622 |
1975 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunodiffusion of perchloric acid extracts of CEA-like material from heterozygote carrier blood indicated that the CEA-like material, which was elevated in homozygotes and heterozygotes for CF, showed only partial identity with two separate CEA preparations obtained from colon carcinomas and was not identical to either A, B, or O(H) blood group substances.
|
824719 |
1976 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Pre-operative CEA levels were measured in 100 patients with large bowel carcinomas with different DNA ploidy pattern and serial post-operative determinations performed in the 64 who had been operated for cure.
|
3816909 |
1986 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Similarly to the 180 kd CEA molecules synthesized by carcinomas, the expression of the melanoma associated CEA like components (MA-CEA) is upregulated by IFN-alpha.
|
3235849 |
1989 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The intensity of signal appeared to be stronger in carcinomas than that in adenomas, and the CEA and NCA mRNAs were expressed together in most of the positive tissue specimens.
|
2125040 |
1990 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When we compared the intensity of the hybridization signal for CEA or NCA mRNA among adenomas, carcinomas and adjacent noninvaded tissues, NCA mRNA rather than CEA mRNA was highly expressed in carcinomas compared to adjacent nonivaded tissues.
|
2067130 |
1991 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas CEA is a suitable marker for aneuploid carcinomas, other more sensitive tumour markers should be sought for diploid and also for tetraploid tumours.
|
1771385 |
1991 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is a 180-kDa glycoprotein expressed on most gastrointestinal carcinomas.
|
1860736 |
1991 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Definition of the expression of the human carcinoembryonic antigen and non-specific cross-reacting antigen in human breast and lung carcinomas.
|
8386136 |
1993 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Western blot analysis showed that the size of the recombinant CEA secreted by the transfected human cells is identical to that of reference CEA purified from human colon carcinomas metastases (about 200 kD).
|
7688074 |
1993 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that PCR amplification of CEA mRNA may lead to an earlier diagnosis of micrometastatic bone disease in patients with CEA-expressing carcinomas.
|
7512130 |
1994 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
This system may be useful in gene therapy that targets CEA-producing gastric carcinomas.
|
8898638 |
1996 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To detect adenocarcinoma cells in the circulating peripheral blood, we "analyzed the presence of carcinoembryonic antigen (CEA) mRNA in the peripheral blood obtained from patients with pancreatic carcinoma (PC) or with gastric carcinoma (GC) and also, as controls, from pancreatitis or gastritis patients without carcinomas, a gastric lymphoma patient and four healthy volunteers.
|
8950323 |
1996 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
CEA is an important tumor marker for colorectal and some other carcinomas.
|
10202129 |
1999 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Human carcinoembryonic antigen (CEA) is a well-characterized oncofetal glycoprotein whose overexpression by human carcinomas has been a target for cancer immunotherapy.
|
9973217 |
1999 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, slightly higher CEA-specific T cell responses were observed in cancer patients with CEA-expressing carcinomas than in healthy blood donors.
|
11129322 |
2000 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings suggest that mammaglobin B and CEA could be useful RT-PCR markers for the detection of lymph node micrometastases in biliary tract carcinomas.
|
10873083 |
2000 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The first clinical trial of an avipox recombinant vaccine for patients with advanced carcinomas has recently been conducted using the ALVAC vector and the human carcinoembryonic antigen (CEA) transgene (designated ALVAC-CEA; J. L. Marshall et al, J. Clin.Oncol., 17: 332-337, 1999).
|
10656428 |
2000 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
MFE-23-his scFv antibody localizes in CEA-producing carcinomas.
|
10815889 |
2000 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Upon co-culture with CEA(+) tumor cells, receptor-grafted T cells are specifically and efficiently activated to cytolysis and IFN-gamma secretion, demonstrating their feasibility for the adoptive immunotherapy of CEA(+) carcinomas.
|
10962448 |
2000 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is expressed on approximately 95% of colorectal, gastric, and pancreatic tumors, and on the majority of breast, non-small cell lung, and head and neck carcinomas.
|
11289125 |
2001 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The resulting hybrid mice developed gastrointestinal polyps in 6-8 months that progressed to invasive carcinomas with a similar pattern of dysplasia and CEA expression as observed in human colorectal cancer.
|
11731437 |
2001 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the newly identified helper T-cell epitope was found to overlap with a previously described HLA-A24-restricted CTL epitope, CEA(652-660), which could facilitate the development of a therapeutic vaccine capable of eliciting both CTL and T helper responses in patients suffering from epithelial carcinomas.
|
12374692 |
2002 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have recently demonstrated that the increased cell surface levels of CEA and CEACAM6 in purified human colonocytes from freshly excised, well to poorly differentiated colon carcinomas are inversely correlated with the degree of cellular differentiation.
|
11896570 |
2002 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) has been suggested as a metastatic activator in colorectal carcinoma, whereas the E-cadherin expression is downregulated in a variety of carcinomas.
|
14592671 |
2003 |