|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunodiffusion of perchloric acid extracts of CEA-like material from heterozygote carrier blood indicated that the CEA-like material, which was elevated in homozygotes and heterozygotes for CF, showed only partial identity with two separate CEA preparations obtained from colon carcinomas and was not identical to either A, B, or O(H) blood group substances.
|
824719 |
1976 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
However, assays of the tissue CEA content in six histologically verified adenomas showed values similar to those of overt colonic carcinomas.
|
1202622 |
1975 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas CEA is a suitable marker for aneuploid carcinomas, other more sensitive tumour markers should be sought for diploid and also for tetraploid tumours.
|
1771385 |
1991 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is a 180-kDa glycoprotein expressed on most gastrointestinal carcinomas.
|
1860736 |
1991 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When we compared the intensity of the hybridization signal for CEA or NCA mRNA among adenomas, carcinomas and adjacent noninvaded tissues, NCA mRNA rather than CEA mRNA was highly expressed in carcinomas compared to adjacent nonivaded tissues.
|
2067130 |
1991 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The intensity of signal appeared to be stronger in carcinomas than that in adenomas, and the CEA and NCA mRNAs were expressed together in most of the positive tissue specimens.
|
2125040 |
1990 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Similarly to the 180 kd CEA molecules synthesized by carcinomas, the expression of the melanoma associated CEA like components (MA-CEA) is upregulated by IFN-alpha.
|
3235849 |
1989 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Pre-operative CEA levels were measured in 100 patients with large bowel carcinomas with different DNA ploidy pattern and serial post-operative determinations performed in the 64 who had been operated for cure.
|
3816909 |
1986 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that PCR amplification of CEA mRNA may lead to an earlier diagnosis of micrometastatic bone disease in patients with CEA-expressing carcinomas.
|
7512130 |
1994 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Western blot analysis showed that the size of the recombinant CEA secreted by the transfected human cells is identical to that of reference CEA purified from human colon carcinomas metastases (about 200 kD).
|
7688074 |
1993 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Definition of the expression of the human carcinoembryonic antigen and non-specific cross-reacting antigen in human breast and lung carcinomas.
|
8386136 |
1993 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
This system may be useful in gene therapy that targets CEA-producing gastric carcinomas.
|
8898638 |
1996 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To detect adenocarcinoma cells in the circulating peripheral blood, we "analyzed the presence of carcinoembryonic antigen (CEA) mRNA in the peripheral blood obtained from patients with pancreatic carcinoma (PC) or with gastric carcinoma (GC) and also, as controls, from pancreatitis or gastritis patients without carcinomas, a gastric lymphoma patient and four healthy volunteers.
|
8950323 |
1996 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Human carcinoembryonic antigen (CEA) is a well-characterized oncofetal glycoprotein whose overexpression by human carcinomas has been a target for cancer immunotherapy.
|
9973217 |
1999 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
CEA is an important tumor marker for colorectal and some other carcinomas.
|
10202129 |
1999 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The first clinical trial of an avipox recombinant vaccine for patients with advanced carcinomas has recently been conducted using the ALVAC vector and the human carcinoembryonic antigen (CEA) transgene (designated ALVAC-CEA; J. L. Marshall et al, J. Clin.Oncol., 17: 332-337, 1999).
|
10656428 |
2000 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
MFE-23-his scFv antibody localizes in CEA-producing carcinomas.
|
10815889 |
2000 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings suggest that mammaglobin B and CEA could be useful RT-PCR markers for the detection of lymph node micrometastases in biliary tract carcinomas.
|
10873083 |
2000 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Upon co-culture with CEA(+) tumor cells, receptor-grafted T cells are specifically and efficiently activated to cytolysis and IFN-gamma secretion, demonstrating their feasibility for the adoptive immunotherapy of CEA(+) carcinomas.
|
10962448 |
2000 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, slightly higher CEA-specific T cell responses were observed in cancer patients with CEA-expressing carcinomas than in healthy blood donors.
|
11129322 |
2000 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is expressed on approximately 95% of colorectal, gastric, and pancreatic tumors, and on the majority of breast, non-small cell lung, and head and neck carcinomas.
|
11289125 |
2001 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The resulting hybrid mice developed gastrointestinal polyps in 6-8 months that progressed to invasive carcinomas with a similar pattern of dysplasia and CEA expression as observed in human colorectal cancer.
|
11731437 |
2001 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have recently demonstrated that the increased cell surface levels of CEA and CEACAM6 in purified human colonocytes from freshly excised, well to poorly differentiated colon carcinomas are inversely correlated with the degree of cellular differentiation.
|
11896570 |
2002 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the newly identified helper T-cell epitope was found to overlap with a previously described HLA-A24-restricted CTL epitope, CEA(652-660), which could facilitate the development of a therapeutic vaccine capable of eliciting both CTL and T helper responses in patients suffering from epithelial carcinomas.
|
12374692 |
2002 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The present approach to manipulating antigen presentation may open new possibilities for immunotherapy against colon and other CEA-secreting carcinomas.
|
12719706 |
2003 |