ADRM1, adhesion regulating molecule 1, 11047

N. diseases: 51; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 Biomarker disease BEFREE Nine hundred patients with subjective cognitive decline plus, mild cognitive impairment, and dementia possibly due to Alzheimer's disease will be randomized to ARM1, amyloid-PET performed early in the diagnostic workup; ARM2, amyloid-PET performed after 8 months; and ARM3, amyloid-PET performed whenever the physician chooses to do so. 30339801 2019
CUI: C0002871
Disease: Anemia
Anemia 		0.010 Biomarker disease BEFREE Para-0 and anemia effect sizes for Arm 1 were > Arm 2 for WAZ and WLRAZ, but not LAZ. 31640153 2019
CUI: C0016053
Disease: Fibromyalgia
Fibromyalgia 		0.010 Biomarker disease BEFREE Arm 1 comprised 33 216 patients with FM and arm 2 consisted of 7420 patients with migraine; all of these patients were diagnosed between 2000 and 2010. 30962236 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.010 Biomarker disease BEFREE This was an open label phase II study of two arms: Arm 1 included anti-angiogenic naïve patients with recurrent GBM and Arm 2 included patients with recurrent GBM that had progressed on prior anti-angiogenic therapy. 31292802 2019
CUI: C0031256
Disease: Petechiae
Petechiae 		0.010 Biomarker disease BEFREE In contrast, animals in the LHBI arm (1 cm above the ilieac crest to the toes) were protected against BM toxicity with no marked changes in hematological parameters and only minor gross pathology [petechiae (1/5), splenomegaly (1/5) and mild pulmonary hemorrhage (1/5)]. 30870098 2019
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		0.010 Biomarker group BEFREE Arm 1 comprised 33 216 patients with FM and arm 2 consisted of 7420 patients with migraine; all of these patients were diagnosed between 2000 and 2010. 30962236 2019
CUI: C0241144
Disease: Petechiae of skin
Petechiae of skin 		0.010 Biomarker phenotype BEFREE In contrast, animals in the LHBI arm (1 cm above the ilieac crest to the toes) were protected against BM toxicity with no marked changes in hematological parameters and only minor gross pathology [petechiae (1/5), splenomegaly (1/5) and mild pulmonary hemorrhage (1/5)]. 30870098 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.010 GeneticVariation disease BEFREE <b>Methods:</b> Patients included in the study had localized prostate cancer (cT1c-T3bN0M0) and were randomly assigned to mild hypofractionated (72 Gy in 32 fractions, arm1) or conventionally fractionated (74 Gy in 37 fractions, arm2) radiation therapy treatment with Volumetric Arc Therapy technique. 31772654 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.010 GeneticVariation disease BEFREE <b>Methods:</b> Patients included in the study had localized prostate cancer (cT1c-T3bN0M0) and were randomly assigned to mild hypofractionated (72 Gy in 32 fractions, arm1) or conventionally fractionated (74 Gy in 37 fractions, arm2) radiation therapy treatment with Volumetric Arc Therapy technique. 31772654 2019
CUI: C0746883
Disease: Febrile Neutropenia
Febrile Neutropenia 		0.010 Biomarker disease BEFREE Febrile neutropenia (FN) occurred in 1 patient in the pegfilgrastim arm (1 of 33 cycles) and none in the filgrastim arm. 31728715 2019
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.010 Biomarker disease BEFREE This was an open label phase II study of two arms: Arm 1 included anti-angiogenic naïve patients with recurrent GBM and Arm 2 included patients with recurrent GBM that had progressed on prior anti-angiogenic therapy. 31292802 2019
CUI: C2938924
Disease: Oestrogen receptor positive breast cancer
Oestrogen receptor positive breast cancer 		0.010 Biomarker disease BEFREE Prognostic and Therapeutic Significance of Adhesion-regulating Molecule 1 in Estrogen Receptor-positive Breast Cancer. 31669266 2019
CUI: C4733092
Disease: estrogen receptor-negative breast cancer
estrogen receptor-negative breast cancer 		0.010 Biomarker disease BEFREE The prognostic value of ADRM1 was better in ER-positive (ER<sup>+</sup>) breast cancer cases than in ER-negative breast cancer cases. 31669266 2019
CUI: C0343751
Disease: Asymptomatic human immunodeficiency virus infection
Asymptomatic human immunodeficiency virus infection 		0.010 Biomarker disease BEFREE Therapy-naive, cognitively asymptomatic, HIV-positive individuals were randomly allocated on a 1 : 1 basis to standard ART (Arm1: tenofovir-emtricitabine and atazanavir/ritonavir) or maraviroc intensified ART (Arm2: abacavir-lamivudine and darunavir/ritonavir/maraviroc). 29438199 2018
CUI: C0345905
Disease: Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma 		0.010 AlteredExpression disease BEFREE ADRM1 levels were significantly higher in ICC tissues than in normal bile duct tissues. 29913454 2018
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.010 GeneticVariation disease BEFREE Thirty-three subjects without cirrhosis were randomized 1:1:1 into three arms (stratified by genotype/subtype and Q80K): Arm 1, simeprevir + sofosbuvir + ribavirin, 12 weeks; Arm 2, simeprevir + sofosbuvir, 12 weeks; Arm 3, simeprevir + sofosbuvir, 24 weeks; 13 additional subjects (two with cirrhosis, 11 without cirrhosis) entered Arm 3. 27896858 2017
CUI: C0270814
Disease: Spastic syndrome
Spastic syndrome 		0.010 Biomarker disease BEFREE Here, we solve the structure of hRpn13 with a segment of hRpn2 that serves as its proteasome docking site; a proline-rich C-terminal hRpn2 extension stretches across a narrow canyon of the ubiquitin-binding hRpn13 Pru domain blocking an RA190-binding surface. 28598414 2017
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.010 GeneticVariation disease BEFREE Thirty-three subjects without cirrhosis were randomized 1:1:1 into three arms (stratified by genotype/subtype and Q80K): Arm 1, simeprevir + sofosbuvir + ribavirin, 12 weeks; Arm 2, simeprevir + sofosbuvir, 12 weeks; Arm 3, simeprevir + sofosbuvir, 24 weeks; 13 additional subjects (two with cirrhosis, 11 without cirrhosis) entered Arm 3. 27896858 2017
CUI: C3839280
Disease: High grade serous carcinoma
High grade serous carcinoma 		0.010 AlteredExpression disease BEFREE ADRM1 mRNA was quantified by RNAscope in situ hybridization and RPN13 protein detected by immunohistochemistry in high grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC). 28784174 2017
CUI: C4287589
Disease: Serous Tubal Intraepithelial Carcinoma
Serous Tubal Intraepithelial Carcinoma 		0.010 AlteredExpression disease BEFREE ADRM1 mRNA was quantified by RNAscope in situ hybridization and RPN13 protein detected by immunohistochemistry in high grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC). 28784174 2017
CUI: C4048329
Disease: Immunosuppression
Immunosuppression 		0.010 Biomarker disease BEFREE RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells. 27655678 2016
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.010 GeneticVariation phenotype BEFREE The most frequently reported treatment-related grade ≥3 AEs were erythematous rash (9.5 %) in Arm 1 and diarrhea, peripheral neuropathy, and neutropenia (14.3 % each) in Arm 2. 25537644 2015
CUI: C0015672
Disease: Fatigue
Fatigue 		0.010 GeneticVariation phenotype BEFREE The most frequently reported treatment-related adverse events (AEs) were diarrhea (23.8 % in Arm 1 vs. 66.7 % in Arm 2), fatigue (14.3 vs. 42.9 %), and rash (33.3 vs. 38.1 %). 25537644 2015
CUI: C0023418
Disease: leukemia
leukemia 		0.010 AlteredExpression disease BEFREE ADRM1 was upregulated in both untreated AL samples and leukemia cell lines. 25896055 2015
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.010 Biomarker disease BEFREE ADRM1 may play a role in AL via the proteasome-ubiquitin pathway by potentially sustaining the activation of NF-κB signaling. 25896055 2015