|
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods:</b> Patients included in the study had localized prostate cancer (cT1c-T3bN0M0) and were randomly assigned to mild hypofractionated (72 Gy in 32 fractions, arm1) or conventionally fractionated (74 Gy in 37 fractions, arm2) radiation therapy treatment with Volumetric Arc Therapy technique.
|
31772654 |
2019 |
|
Prostate carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods:</b> Patients included in the study had localized prostate cancer (cT1c-T3bN0M0) and were randomly assigned to mild hypofractionated (72 Gy in 32 fractions, arm1) or conventionally fractionated (74 Gy in 37 fractions, arm2) radiation therapy treatment with Volumetric Arc Therapy technique.
|
31772654 |
2019 |
|
Febrile Neutropenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Febrile neutropenia (FN) occurred in 1 patient in the pegfilgrastim arm (1 of 33 cycles) and none in the filgrastim arm.
|
31728715 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Adrm1 mRNA was overexpressed in 46.2% (18/39) colorectal cancer tissues compared to their matched normal mucosa and significantly correlated with lymph node metastasis of colorectal cancer (P=0.037).
|
19148532 |
2009 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Adhesion regulating molecule 1 (ADRM1), a 19S proteasome cap-associated protein, and nuclear factor kappa B (NF-κB), a protein transcription factor controlling DNA transcription, may play an important role in tumorigenesis.
|
22576803 |
2012 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
ADRM1 gene amplification is a candidate driver for metastatic gastric cancers.
|
24968865 |
2014 |
|
leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ADRM1 was upregulated in both untreated AL samples and leukemia cell lines.
|
25896055 |
2015 |
|
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ADRM1 was upregulated in both untreated AL samples and leukemia cell lines.
|
25896055 |
2015 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
ADRM1 may play a role in AL via the proteasome-ubiquitin pathway by potentially sustaining the activation of NF-κB signaling.
|
25896055 |
2015 |
|
High grade serous carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ADRM1 mRNA was quantified by RNAscope in situ hybridization and RPN13 protein detected by immunohistochemistry in high grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC).
|
28784174 |
2017 |
|
Serous Tubal Intraepithelial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ADRM1 mRNA was quantified by RNAscope in situ hybridization and RPN13 protein detected by immunohistochemistry in high grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC).
|
28784174 |
2017 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ADRM1 levels were significantly higher in ICC tissues than in normal bile duct tissues.
|
29913454 |
2018 |
|
Fibromyalgia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Arm 1 comprised 33 216 patients with FM and arm 2 consisted of 7420 patients with migraine; all of these patients were diagnosed between 2000 and 2010.
|
30962236 |
2019 |
|
Migraine Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Arm 1 comprised 33 216 patients with FM and arm 2 consisted of 7420 patients with migraine; all of these patients were diagnosed between 2000 and 2010.
|
30962236 |
2019 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Although knowledge has accumulated about GP110-CD4 interaction, viral penetration into human CD4+ lymphocytes remains unclear, in spite of the fact that all studies on HIV infection were performed on cell-transformed lineages, or on human polyclonal CD4+ cells.
|
2121340 |
1990 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
An analysis of protein and DNA databases revealed that the Epstein-Barr virus glycoprotein gp110, which is encoded by the BALF4 open reading frame, contains the sequence QKRAAQRAA, which is highly homologous to the rheumatoid arthritis susceptibility determinant.
|
2472638 |
1989 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cell-mediated responses to EBV replicative cycle proteins and to gp110 have been documented in joint fluid from RA patients.
|
17625943 |
2007 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Collectively, these data suggested that Adrm1 is potentially oncogenic and may play an important role in colon tumorigenesis.
|
19148532 |
2009 |
|
Malignant neoplasm of ovary
|
0.030 |
Biomarker
|
disease |
BEFREE |
Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer.
|
18615678 |
2008 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer.
|
18615678 |
2008 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer.
|
18615678 |
2008 |
|
ovarian neoplasm
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer.
|
18615678 |
2008 |
|
Malignant neoplasm of ovary
|
0.030 |
Biomarker
|
disease |
BEFREE |
Further research is necessary to determine whether targeting knockdown of ADRM1 in 20q13-amplified ovarian cancers results in growth inhibition and tumor suppression via downstream targets GIPC1 and RECK.
|
21432940 |
2011 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Further research is necessary to determine whether targeting knockdown of ADRM1 in 20q13-amplified ovarian cancers results in growth inhibition and tumor suppression via downstream targets GIPC1 and RECK.
|
21432940 |
2011 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, ADRM1 knockdown inhibited MHCC97-H cell proliferation and induced cell apoptosis, and the migration and invasion of MHCC97-H cells were significantly repressed.
|
22576803 |
2012 |