NISCH, nischarin, 11188

N. diseases: 49; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.010 GeneticVariation disease BEFREE In the application to the real datasets, DCL identified rs6784615, located on the NISCH gene, and rs10824310, located on the PRKG1 gene, as direct causes of late onset Alzheimer's disease (LOAD) development. 28363452 2017
CUI: C0003467
Disease: Anxiety
Anxiety 		0.100 GeneticVariation disease GWASCAT Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. 29942085 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 Biomarker disease BEFREE These results are consistent with the expectation that intermediate measures of insulin resistance and visceral adiposity are heritable, and that the IRAS Family Study has statistical power to detect these intermediate phenotypes of type 2 diabetes and atherosclerosis. 12684185 2003
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 GeneticVariation disease BEFREE We evaluated data from the Insulin Resistance Atherosclerosis Study (IRAS Exam I, 1992-1994). 14594783 2003
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 Biomarker disease BEFREE We have previously measured insulin action in a large cohort of subjects (Insulin Resistance and Atherosclerosis Study [IRAS] Family Study) using the minimal model approach. 12882937 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 Biomarker disease BEFREE We have previously measured insulin action in a large cohort of subjects (Insulin Resistance and Atherosclerosis Study [IRAS] Family Study) using the minimal model approach. 12882937 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 GeneticVariation disease BEFREE We evaluated data from the Insulin Resistance Atherosclerosis Study (IRAS Exam I, 1992-1994). 14594783 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 Biomarker disease BEFREE These results are consistent with the expectation that intermediate measures of insulin resistance and visceral adiposity are heritable, and that the IRAS Family Study has statistical power to detect these intermediate phenotypes of type 2 diabetes and atherosclerosis. 12684185 2003
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.010 Biomarker disease BEFREE We identified multiple genes and pathways with common or disease specific effects, such as NISCH (P = 9.87 × 10<sup>-3</sup> for BP and 2.49 × 10<sup>-6</sup> for SCZ), ST3GAL3 (P = 1.19 × 10<sup>-2</sup> for ADHD), and KEGG_MAPK_SIGNALING_PATHWAY (P = 1.56 × 10<sup>-3</sup> for ADHD, P = 4.71 × 10<sup>-2</sup> for BP, P = 4.60 × 10<sup>-4</sup> for SCZ). 30339835 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.010 Biomarker disease BEFREE We identified multiple genes and pathways with common or disease specific effects, such as NISCH (P = 9.87 × 10<sup>-3</sup> for BP and 2.49 × 10<sup>-6</sup> for SCZ), ST3GAL3 (P = 1.19 × 10<sup>-2</sup> for ADHD), and KEGG_MAPK_SIGNALING_PATHWAY (P = 1.56 × 10<sup>-3</sup> for ADHD, P = 4.71 × 10<sup>-2</sup> for BP, P = 4.60 × 10<sup>-4</sup> for SCZ). 30339835 2018
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
CUI: C0428977
Disease: Bradycardia
Bradycardia 		0.300 Biomarker phenotype CTD_human Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats. 11486246 2001
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 Biomarker disease BEFREE The significant differences in the expression of Nischarin between: i) Cancer tissue and noncancerous tissue and ii) patients with and without lymph node metastasis, suggested that Nischarin may have a significant role in tumor occurrence and metastasis of breast cancer. 25695373 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 Biomarker disease BEFREE Nischarin (NISCH) is a cytoplasmic protein known to serve an inhibitory role in breast cancer cell apoptosis, migration and invasion. 30651848 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 Biomarker disease BEFREE Furthermore, we discuss data illustrating a novel role of Nischarin as a tumor suppressor in breast cancer. 26392073 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 Biomarker disease BEFREE Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth. 30635277 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 Biomarker disease CTD_human In summary, this project provides further clarity concerning the function of Malat1, specifically in breast cancer, while also indicating that the Nischarin expression context is an important factor in the determining how Malat1 activity is governed in breast cancer. 29912916 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 AlteredExpression disease BEFREE In summary, this project provides further clarity concerning the function of Malat1, specifically in breast cancer, while also indicating that the Nischarin expression context is an important factor in the determining how Malat1 activity is governed in breast cancer. 29912916 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 Biomarker disease BEFREE These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer. 29415725 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 Biomarker disease BEFREE Our study aimed to analyze the association between Nischarin expression and clinical features of breast cancer patients, and further investigate the role of Nischarin in breast cancer cells apoptosis, migration and invasion. 28131840 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 Biomarker disease BEFREE We subsequently described a role for Nischarin in breast cancer, in which it is frequently underexpressed. 31525254 2020
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.390 AlteredExpression disease BEFREE We examined nischarin expression in approximately 300 human breast cancer and normal tissues using quantitative polymerase chain reaction and immunohistochemistry. 21917605 2011
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE Knockout model reveals the role of Nischarin in mammary gland development, breast tumorigenesis and response to metformin treatment. 31525254 2020
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.010 Biomarker disease BEFREE Expression of integrin-binding protein Nischarin in metastatic breast cancer. 25695373 2015
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.010 GeneticVariation disease BEFREE Interestingly, in light smokers, NISCH methylation was present in 69% of patients with lung cancer and absent in those without disease. 23503203 2013