|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We examined nischarin expression in approximately 300 human breast cancer and normal tissues using quantitative polymerase chain reaction and immunohistochemistry.
|
21917605 |
2011 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
The significant differences in the expression of Nischarin between: i) Cancer tissue and noncancerous tissue and ii) patients with and without lymph node metastasis, suggested that Nischarin may have a significant role in tumor occurrence and metastasis of breast cancer.
|
25695373 |
2015 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study aimed to analyze the association between Nischarin expression and clinical features of breast cancer patients, and further investigate the role of Nischarin in breast cancer cells apoptosis, migration and invasion.
|
28131840 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
We subsequently described a role for Nischarin in breast cancer, in which it is frequently underexpressed.
|
31525254 |
2020 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth.
|
30635277 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, we discuss data illustrating a novel role of Nischarin as a tumor suppressor in breast cancer.
|
26392073 |
2015 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Notably, these miRNAs and Nischarin were inversely expressed in human breast cancers, underscoring their biologic relevance.
|
23338610 |
2013 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, this project provides further clarity concerning the function of Malat1, specifically in breast cancer, while also indicating that the Nischarin expression context is an important factor in the determining how Malat1 activity is governed in breast cancer.
|
29912916 |
2018 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nischarin (NISCH) is a cytoplasmic protein known to serve an inhibitory role in breast cancer cell apoptosis, migration and invasion.
|
30651848 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer.
|
29415725 |
2018 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
The significant differences in the expression of Nischarin between: i) Cancer tissue and noncancerous tissue and ii) patients with and without lymph node metastasis, suggested that Nischarin may have a significant role in tumor occurrence and metastasis of breast cancer.
|
25695373 |
2015 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Nischarin (NISCH) is a cytoplasmic protein known to serve an inhibitory role in breast cancer cell apoptosis, migration and invasion.
|
30651848 |
2019 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Furthermore, we discuss data illustrating a novel role of Nischarin as a tumor suppressor in breast cancer.
|
26392073 |
2015 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth.
|
30635277 |
2019 |
|
Breast Carcinoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
In summary, this project provides further clarity concerning the function of Malat1, specifically in breast cancer, while also indicating that the Nischarin expression context is an important factor in the determining how Malat1 activity is governed in breast cancer.
|
29912916 |
2018 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer.
|
29415725 |
2018 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Our study aimed to analyze the association between Nischarin expression and clinical features of breast cancer patients, and further investigate the role of Nischarin in breast cancer cells apoptosis, migration and invasion.
|
28131840 |
2017 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
We subsequently described a role for Nischarin in breast cancer, in which it is frequently underexpressed.
|
31525254 |
2020 |
|
Breast Carcinoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
We examined nischarin expression in approximately 300 human breast cancer and normal tissues using quantitative polymerase chain reaction and immunohistochemistry.
|
21917605 |
2011 |
|
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
Our studies, for the first time, demonstrate functional interaction between LKB1 and Nischarin to inhibit cell migration and breast tumor progression.
|
23572524 |
2013 |
|
Mammary Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Normal human breast tissue samples had statistically significantly higher expression of nischarin mRNA compared with tumor tissue samples (mean level in normal breast = 50.7 [arbitrary units], in breast tumor = 16.49 [arbitrary units], difference = 34.21, 95% confidence interval [CI] = 11.63 to 56.79, P = .003), and loss of heterozygosity was associated with loss of nischarin expression.
|
21917605 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MDA-MB-231 cells in which nischarin was overexpressed had statistically significantly reduced tumor growth and metastasis compared with parental MDA-MB-231 cells (mean volume at day 40, control vs nischarin-expressing tumors, 1977 vs 42.27 mm(3), difference = 1935 mm(3), 95% CI = 395 to 3475 mm(3), P = .025).
|
21917605 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor Nischarin interacts with a number of signaling proteins such as Integrin α5, PAK1, LIMK1, LKB1, and Rac1 to prevent cancer cell migration.
|
29415725 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, we discuss data illustrating a novel role of Nischarin as a tumor suppressor in breast cancer.
|
26392073 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, intraperitoneally delivered anti-miR-27b restored Nischarin expression and decreased tumor burden in a mouse xenograft model of human mammary tumor.
|
23338610 |
2013 |