|
Abnormal behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders.
|
23490763 |
2013 |
|
Action Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Catatonia
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Effect of M4-cholinoceptor blockade on haloperidol-produced catatonic syndrome in rats.
|
15273762 |
2004 |
|
Catatonia, Malignant
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Effect of M4-cholinoceptor blockade on haloperidol-produced catatonic syndrome in rats.
|
15273762 |
2004 |
|
Catatonia, Organic
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
Effect of M4-cholinoceptor blockade on haloperidol-produced catatonic syndrome in rats.
|
15273762 |
2004 |
|
Coarse Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Cocaine Dependence
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (Pcorrected = 0.047).
|
27269905 |
2016 |
|
Congestive heart failure
|
0.200 |
Biomarker
|
disease |
RGD |
In CHF hearts, the expression of the muscarinic m4 (Chrm4) and nicotinic alpha4 (Chrna4) acetylcholin receptors, the ATP receptor P2rx4, nerve growth factor receptor (Ngfr), discoidin domain receptor 1 (Ddr1), neuronal pentraxin receptor (Nptxr), peripheral myelin protein Pmp-22, leukocyte type 12-lipoxygenase (Alox15), cytochrome P450 4F5 (Cyp4F5) and cardiac Kcne1 were all increased (range 1.6-6.0-fold, P < 0.01 for all genes).
|
16497176 |
2006 |
|
Continuous Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Darkness Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Fine Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Heart failure
|
0.200 |
Biomarker
|
disease |
RGD |
Regulation of neuronal type genes in congestive heart failure rats.
|
16497176 |
2006 |
|
Intermittent Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Involuntary Quiver
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Massive Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Mental disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders.
|
23490763 |
2013 |
|
MYELODYSPLASTIC SYNDROME
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we found that the muscarinic acetylcholine receptor, cholinergic receptor, muscarinic 4 (CHRM4), pathway regulates BFU-E self-renewal and that pharmacological inhibition of CHRM4 corrects anemias of myelodysplastic syndrome (MDS), aging, and hemolysis.
|
31554738 |
2019 |
|
Nerve Tremors
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Passive Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Persistent Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Pill Rolling Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Resting Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Saturnine Tremor
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
|
9920179 |
1999 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
PSYGENET |
Genetic variation in a region on chromosome 11 that contains the candidate genes AMBRA1, DGKZ, CHRM4 and MDK was significantly associated with SCZ in the combined sample (n=11 540; P=3.89 × 10(-9), odds ratio (OR)=1.25).
|
21747397 |
2012 |
|
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
LHGDN |
To test the hypothesis that muscarinic receptors are involved in the pathology of schizophrenia, we measured muscarinic(1) (M1R) and muscarinic(4)(M4R) protein and mRNA as well as [(3)H]pirenzepine binding in Brodmann's areas (BA) 9 and 40 obtained postmortem from 20 schizophrenic and 20 age/sex-matched control subjects.
|
12476323 |
2002 |