CHRM4, cholinergic receptor muscarinic 4, 1132

N. diseases: 33; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE Genetic variation in a region on chromosome 11 that contains the candidate genes AMBRA1, DGKZ, CHRM4 and MDK was significantly associated with SCZ in the combined sample (n=11 540; P=3.89 × 10(-9), odds ratio (OR)=1.25). 21747397 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 GeneticVariation disease BEFREE RNA-sequencing analyses of cortical and striatal micropunches from Brd1<sup>+/-</sup> and wild-type mice revealed differential expression of genes enriched for schizophrenia risk, including several schizophrenia genome-wide association study risk genes (e.g., calcium channel subunits [Cacna1c and Cacnb2], cholinergic muscarinic receptor 4 [Chrm4)], dopamine receptor D<sub>2</sub> [Drd2], and transcription factor 4 [Tcf4]). 27837920 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE To test the hypothesis that muscarinic receptors are involved in the pathology of schizophrenia, we measured muscarinic(1) (M1R) and muscarinic(4)(M4R) protein and mRNA as well as [(3)H]pirenzepine binding in Brodmann's areas (BA) 9 and 40 obtained postmortem from 20 schizophrenic and 20 age/sex-matched control subjects. 12476323 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 GeneticVariation disease BEFREE These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders. 23490763 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 GeneticVariation disease BEFREE CHRM4 is located in a region of strong linkage disequilibrium on chromosome 11 that includes genes associated with schizophrenia. 27269905 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 GeneticVariation disease BEFREE For example, an elegant roadmap was laid out a year ago by Karolina Kauppi and colleagues wherein they combined a data set for schizophrenia risk genes and another set of genes associated with antipsychotic drug targets.<sup>3</sup> Using this "network biology" approach, they identified four schizophrenia risk genes that were also antipsychotic drug targets (GRM3, DRD2, CHRM4, and CYP2D6); they also found several molecular targets that are not currently connected to antipsychotic drug treatment, providing researchers with some potential targets for novel therapeutics.<sup>4</sup>. 31340894 2019
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 GeneticVariation group BEFREE These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders. 23490763 2013
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 GeneticVariation phenotype BEFREE These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders. 23490763 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.010 GeneticVariation disease BEFREE Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (Pcorrected = 0.047). 27269905 2016
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.010 Biomarker group BEFREE Here, we found that the muscarinic acetylcholine receptor, cholinergic receptor, muscarinic 4 (CHRM4), pathway regulates BFU-E self-renewal and that pharmacological inhibition of CHRM4 corrects anemias of myelodysplastic syndrome (MDS), aging, and hemolysis. 31554738 2019
CUI: C0007398
Disease: Catatonia
Catatonia 		0.300 Therapeutic disease CTD_human Effect of M4-cholinoceptor blockade on haloperidol-produced catatonic syndrome in rats. 15273762 2004
CUI: C0040822
Disease: Tremor
Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0040827
Disease: Saturnine Tremor
Saturnine Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0149840
Disease: Senile Tremor
Senile Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234370
Disease: Persistent Tremor
Persistent Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234371
Disease: Continuous Tremor
Continuous Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234372
Disease: Intermittent Tremor
Intermittent Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234373
Disease: Fine Tremor
Fine Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234374
Disease: Coarse Tremor
Coarse Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234375
Disease: Massive Tremor
Massive Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234376
Disease: Action Tremor
Action Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234377
Disease: Passive Tremor
Passive Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234378
Disease: Static Tremor
Static Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234379
Disease: Resting Tremor
Resting Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234381
Disease: Darkness Tremor
Darkness Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999