|
Aarskog syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In patients with isolated familial glucocorticoid deficiency (FGD), in which no mutations in the genes for the ACTH receptor (<i>MC2R</i>) or its accessory protein MRAP have been found, non-classic steroidogenic acute regulatory protein (<i>StAR</i>) and <i>CYP11A1</i> mutations have been described; and more recently novel mutations in genes such as nicotinamide nucleotide transhydrogenase (<i>NNT</i>) and thioredoxin reductase 2 (<i>TRXR2</i>) involved in the maintenance of the mitochondrial redox potential and generation of NADPH important for steroidogenesis and ROS detoxication have been discovered.
|
28450305 |
2017 |
|
Agenesis of corpus callosum
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>MYB</i> gene translocation was observed and significantly correlated with overexpression of MYB but did not correlate with FGFR1 phosphorylation or clinical response to dovitinib.<b>Conclusions:</b> Dovitinib produced few objective responses in patients with ACC but did suppress the TGR with a PFS that compares favorably with those reported with other targeted agents.
|
28377480 |
2017 |
|
Aplasia Cutis Congenita
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>MYB</i> gene translocation was observed and significantly correlated with overexpression of MYB but did not correlate with FGFR1 phosphorylation or clinical response to dovitinib.<b>Conclusions:</b> Dovitinib produced few objective responses in patients with ACC but did suppress the TGR with a PFS that compares favorably with those reported with other targeted agents.
|
28377480 |
2017 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among patients having good response (n=112, ACT score increased ≥3 points) to tiotropium (TGR group) and patients having poor response (n=48, ACT increased <3 points) to tiotropium (TPR group), their baseline characteristics including age, asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO), cigarette use, initial FEV1, serum IgE level, eosinophil count, and BMI were significantly different.
|
30069364 |
2018 |
|
Benign Prostatic Hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, thioredoxin reductase 2 protein was clearly shown to be a biomarker of prostate cancer-associated reactive stroma whose presence distinguishes the stroma associated with benign prostatic hyperplasia from that associated with prostate cancer.
|
23762225 |
2013 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We have used the TGR(alpha MHC-h AT1) rat model, which overexpresses the human AT1 receptor in the myocardium, to study some of the associations between an increased AT1-receptor number and cardiovascular disorders.
|
9717050 |
1998 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among patients having good response (n=112, ACT score increased ≥3 points) to tiotropium (TGR group) and patients having poor response (n=48, ACT increased <3 points) to tiotropium (TPR group), their baseline characteristics including age, asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO), cigarette use, initial FEV1, serum IgE level, eosinophil count, and BMI were significantly different.
|
30069364 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the association between genetic variation in TXNRD1, TXNRD2, TXNRD3, C11orf31 (SelH), SelW, SelN1, SelS, SepX, and SeP15 with colorectal cancer risk.
|
22615972 |
2012 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
The previously identified let-7i-5p, miR-16-5p, miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-199a-3p, miR-223-3p, miR-423-3p, miR-423-5p and miR-652-3p were measured by means of quantitative real time polymerase chain reaction (qRT-PCR) in plasma samples of 8 homozygous TGR(mREN2)27 (Ren2) transgenic rats and 8 (control) Sprague-Dawley rats, 6 mice with angiotensin II-induced heart failure (AngII) and 6 control mice, and 8 mice with ischemic heart failure and 6 controls.
|
28475616 |
2017 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
To evaluate the impact of SERCA2a overexpression on SR Ca2+ handling in diabetic CM, we 1) generated transgenic rats harboring a human cytomegalovirus enhancer/chicken beta-actin promotor-controlled rat SERCA2 transgene (SERCA2-TGR), 2) characterized their SR phenotype, and 3) examined whether transgene expression may rescue SR Ca2+ transport in streptozotocin-induced diabetes.
|
12206992 |
2002 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
To evaluate the impact of SERCA2a overexpression on SR Ca2+ handling in diabetic CM, we 1) generated transgenic rats harboring a human cytomegalovirus enhancer/chicken beta-actin promotor-controlled rat SERCA2 transgene (SERCA2-TGR), 2) characterized their SR phenotype, and 3) examined whether transgene expression may rescue SR Ca2+ transport in streptozotocin-induced diabetes.
|
12206992 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship between genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and myocardial infarction (MI) in subjects with type 2 diabetes mellitus (T2DM) of Slovenian origin.
|
25703281 |
2015 |
|
Diabetic Cardiomyopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
In SERCA2-TGR, contraction amplitude (+48%) and rates of contraction (+34%) and relaxation (+35%) of isolated papillary muscles (PM) were increased (P2+ uptake and SERCA2 protein of SERCA2-TGR were 1.3-fold higher (P2+ uptake, accelerates relaxation and compensates, in part, for depressed Ca2+ uptake in diabetic CM.
|
12206992 |
2002 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
The extent of liver fibrosis was assessed in TGR(mREN2)27 and wild-type rats using standard techniques.
|
31406138 |
2019 |
|
Glomerulosclerosis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Administration of either an orally active inhibitor of the type 2 VEGF receptor (VEGFR-2) tyrosine kinase or a VEGF neutralizing antibody to TGR(mRen-2)27 rats resulted in loss of glomerular endothelial cells and transformation to a malignant hypertensive phenotype with severe glomerulosclerosis.
|
17726104 |
2007 |
|
Goldblatt's kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
Animal models of hypertension have ranged from Goldblatt's kidney clip models in which the origin of the disease is clearly renal to animals that spontaneously develop hypertension either through targeted genetic manipulations, such as the TGR(mRen2)27, or selective breeding resulting in more enigmatic origins, as exemplified by the spontaneously hypertensive rat (SHR).
|
28353076 |
2017 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
The previously identified let-7i-5p, miR-16-5p, miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-199a-3p, miR-223-3p, miR-423-3p, miR-423-5p and miR-652-3p were measured by means of quantitative real time polymerase chain reaction (qRT-PCR) in plasma samples of 8 homozygous TGR(mREN2)27 (Ren2) transgenic rats and 8 (control) Sprague-Dawley rats, 6 mice with angiotensin II-induced heart failure (AngII) and 6 control mice, and 8 mice with ischemic heart failure and 6 controls.
|
28475616 |
2017 |
|
Hypertensive disease
|
0.070 |
Biomarker
|
group |
BEFREE |
Compared with Sprague-Dawley (SD) control rats (n= 11), male homozygous TGR(hAGT)L1623 (n= 9) demonstrated sustained daytime and nighttime hypertension associated with no changes in heart rate but increased heart rate lability.
|
26873967 |
2016 |
|
Hypertensive disease
|
0.070 |
Biomarker
|
group |
BEFREE |
To address this, TGR(mREN2)27 rats (a model of angiotensin II-dependent hypertension) were made diabetic for 12 weeks and treated with vehicle (n = 10), valsartan (ARB; n = 7) or sacubitril/valsartan (ARNI; n = 8) for the final 3 weeks.
|
31790054 |
2020 |
|
Hypertensive disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Animal models of hypertension have ranged from Goldblatt's kidney clip models in which the origin of the disease is clearly renal to animals that spontaneously develop hypertension either through targeted genetic manipulations, such as the TGR(mRen2)27, or selective breeding resulting in more enigmatic origins, as exemplified by the spontaneously hypertensive rat (SHR).
|
28353076 |
2017 |
|
Hypertensive disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Remarkably, in TGR with established hypertension, AAA also decreased SBP (from 187 ± 4 to 158 ± 4 mmHg, <i>P</i><0.05) and exhibited organoprotective effects in addition to marked suppression of kidney ANG II levels.
|
30054426 |
2018 |
|
Hypertensive disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Female rats harboring the human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype with hypertension and albuminuria during pregnancy when mated with male rats bearing the human renin gene [TGR(hRen)L10J] but behave physiologically normal before and after pregnancy.
|
31786987 |
2020 |
|
Hypertensive disease
|
0.070 |
Biomarker
|
group |
BEFREE |
Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats.
|
7699997 |
1994 |
|
Hypertensive disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Chronically elevated Ang II in TGR(hAGT)L1623 hearts leading to increased intracellular calcium through I<sub>Ca-L</sub> suggests that activation of this Ang-(1-12)/chymase-governed cardiac intracrine RAS may contribute to the pathological phenotypes observed in the humanized model of chronic hypertension and cardiac hypertrophy.
|
31629566 |
2019 |
|
Hyperthyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate the effects of elevated circulating Ang-(1-7) levels on cardiac effects promoted by hyperthyroidism in a transgenic rat (TG) model that constitutively overexpresses an Ang-(1-7)-producing fusion protein [TGR(A1-7)3292].
|
29685981 |
2018 |