|
Left Ventricular Hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
TGR rats showed left ventricular hypertrophy (54%), higher blood pressures (76 mmHg), and elevated plasma renin activity (seven-fold) compared to controls (P < 0.01).
|
11518854 |
2001 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In recent years, a plethora of TGR-β have been developed and some of them are under clinical investigations for testing in patients with advanced HCC.
|
29150921 |
2018 |
|
Malignant Hypertension
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study was performed to determine if urinary angiotensinogen excretion is increased in Cyp1a1-Ren2 transgenic rats [strain name: TGR(Cyp1aRen2)] with inducible ANG II-dependent malignant hypertension.
|
20724906 |
2010 |
|
Malignant Hypertension
|
0.020 |
Biomarker
|
disease |
BEFREE |
TGR(mREN2)27 heterozygotes (HanRen2/Edin- -) have previously been shown to develop malignant hypertension spontaneously and exhibit the characteristic features of human malignant hypertension.
|
9797175 |
1998 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the association between genetic variation in TXNRD1, TXNRD2, TXNRD3, C11orf31 (SelH), SelW, SelN1, SelS, SepX, and SeP15 with colorectal cancer risk.
|
22615972 |
2012 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, thioredoxin reductase 2 protein was clearly shown to be a biomarker of prostate cancer-associated reactive stroma whose presence distinguishes the stroma associated with benign prostatic hyperplasia from that associated with prostate cancer.
|
23762225 |
2013 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Given the interdependence between adenosinic and dopaminergic function, the present results render the novel TGR(NSEhA2A) as a putative animal model for the working memory deficits and cognitive disruptions related to overstimulation of cortical A(2A)Rs or to dopaminergic prefrontal dysfunction as seen in schizophrenic or Parkinson's disease patients.
|
16824773 |
2007 |
|
Multiple Chronic Conditions
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thioredoxin glutathione reductase (TGRsec) is a multi-domain flavoprotein that plays a principal role in redox homeostasis maintenance.
|
30205085 |
2018 |
|
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship between genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and myocardial infarction (MI) in subjects with type 2 diabetes mellitus (T2DM) of Slovenian origin.
|
25703281 |
2015 |
|
Myocardial Infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, despite similar unchanged infarction sizes, left ventricular function and remodeling improved in TGR(hKLK1) after myocardial infarction, indicated by an increase in left ventricular pressure (+34%; P<0.05), contractility (dp/dt max.
|
17022964 |
2006 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we used TGR(mREN2)27 rats as a model of NAFLD where we hypothesized increased susceptibility and investigated fibrosis and portal hypertension and associated pathways.
|
31406138 |
2019 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
TGR(ASrAOGEN) were protected from developing obesity.
|
29430615 |
2018 |
|
Parasitic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thioredoxin glutathione reductase (TGR), a high molecular weight thioredoxin reductase-like enzyme, has emerged as a promising drug target for the treatment of schistosomiasis, a parasitosis afflicting more than 200 million people.
|
29800515 |
2018 |
|
Parkinson Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Given the interdependence between adenosinic and dopaminergic function, the present results render the novel TGR(NSEhA2A) as a putative animal model for the working memory deficits and cognitive disruptions related to overstimulation of cortical A(2A)Rs or to dopaminergic prefrontal dysfunction as seen in schizophrenic or Parkinson's disease patients.
|
16824773 |
2007 |
|
Parkinson Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The human TR2 gene is located on chromosome 2q32.3, near a locus linked to Parkinson's disease.
|
16805794 |
2006 |
|
Portal Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
TGR(mREN2)27 rats developed spontaneous, but mild fibrosis and portal hypertension due to the activation of the JAK2/Arhgef1/ROCK pathway.
|
31406138 |
2019 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, thioredoxin reductase 2 protein was clearly shown to be a biomarker of prostate cancer-associated reactive stroma whose presence distinguishes the stroma associated with benign prostatic hyperplasia from that associated with prostate cancer.
|
23762225 |
2013 |
|
Psoriasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The result of a preliminary association study between psoriasis and single microsatellite marker of the TXNRD3NT1 gene suggests that it may not be a significant genetic determinant of psoriasis.
|
15674732 |
2005 |
|
Rectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs in TXNRD1 and four SNPs in TXNRD2 interacted with aspirin/NSAID to influence colon cancer; one SNP in TXNRD1, two SNPs in TXNRD2, and one SNP in TXNRD3 interacted with aspirin/NSAIDs to influence rectal cancer.
|
22615972 |
2012 |
|
Schistosomiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thioredoxin glutathione reductase (TGR), a high molecular weight thioredoxin reductase-like enzyme, has emerged as a promising drug target for the treatment of schistosomiasis, a parasitosis afflicting more than 200 million people.
|
29800515 |
2018 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have studied eight markers spanning COMT and including portions of the two immediately adjacent genes, thioredoxin reductase 2 and armadillo repeat deleted in velocardiofacial syndrome (ARVCF), using association testing in 136 schizophrenia families.
|
15340358 |
2005 |